Patents by Inventor Rafael A. Garcia

Rafael A. Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10774245
    Abstract: Adhesive tapes include a plasticized polyvinyl chloride backing, a primer including an ethylene/carbon monoxide-containing terpolymer, and an adhesive.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: September 15, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Jeffrey O. Emslander, Ann R. Fornof, Rafael Garcia-Ramirez, Jay M. Krieger, Gregg A. Patnode, Robert B. Rosner, Christopher J. Rother, Jose P. de Souza, Jacob D. Young
  • Publication number: 20200277204
    Abstract: Disclosed are methods to remove organic and/or inorganic compounds (e.g., contaminants) from water containing organic and/or inorganic compounds, involving contacting the water with an effective organic and/or inorganic compounds removing amount of hemoglobin/Fe3O4 composite where the compounds in the water adsorb onto the hemoglobin/Fe3O4 composite, and removing (e.g., using a magnet since the composite is magnetic) the hemoglobin/Fe3O4 composite from the water.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 3, 2020
    Inventors: Matthew Essandoh, Rafael A. Garcia
  • Patent number: 10702326
    Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: July 7, 2020
    Assignees: Virginia Tech Intellectual Properties, Inc., AngioDynamics, Inc.
    Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, Peter Callas
  • Publication number: 20200197073
    Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
    Type: Application
    Filed: January 20, 2020
    Publication date: June 25, 2020
    Inventors: Michael B. Sano, Rafael V. Davalos, John L. Robertson, Paulo A. Garcia, Robert E. Neal
  • Patent number: 10689267
    Abstract: Disclosed are methods to remove organic and/or inorganic compounds (e.g., contaminants) from water containing organic and/or inorganic compounds, involving contacting the water with an effective organic and/or inorganic compounds removing amount of hemoglobin/Fe3O4 composite where the compounds in the water adsorb onto the hemoglobin/Fe3O4 composite, and removing (e.g., using a magnet since the composite is magnetic) the hemoglobin/Fe3O4 composite from the water.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 23, 2020
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Matthew Essandoh, Rafael A. Garcia
  • Patent number: 10662287
    Abstract: The present invention refers to a formulation suitable for the manufacture of a pressure sensitive adhesive, said formulation comprising: a) 40-95 wt % of polyalkylene carbonate having a number average molecular weight higher than 17.000 Da; b) 5-60 wt % of a polyether carbonate polyol having CO2 groups randomly incorporated in the chemical structure thereof, wherein the content of CO2 ranges from 0.5 to 40 wt %, based on the total weight of the polyether carbonate polyol; and c) optionally, less than 30 wt % of a tackifying resin, provided that said formulation does not contain any reticulating agent.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: May 26, 2020
    Assignee: REPSOL, S.A.
    Inventors: Carolina Ruiz Orta, Laura Marín Perales, Sonia Segura Fernández, Rafael Polo Abad, María Dolores Blanco González, Román Galdámez Peña, Mónica García Ruiz, José Miguel Martín Martínez, Andrés Jesús Yáñez Pacios
  • Publication number: 20200093541
    Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
    Type: Application
    Filed: July 24, 2015
    Publication date: March 26, 2020
    Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
  • Publication number: 20200046432
    Abstract: The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 13, 2020
    Inventors: Paulo A. Garcia, Rafael V. Davalos
  • Publication number: 20200040409
    Abstract: The present disclosure is in the field of plant breeding. The disclosure provides methods for breeding corn plants having a brachytic trait using marker-assisted selection. The disclosure further provides brachytic germplasm, markers associated with a brachytic trait for introgressing the trait into elite germplasm in a breeding program. This disclosure also provides brachytic or dwarf elite corn varieties having yield equal to or higher than conventional non-brachytic corn varieties.
    Type: Application
    Filed: October 1, 2019
    Publication date: February 6, 2020
    Applicant: Monsanto Technology LLC
    Inventors: Ty Jason Barten, Alana N. Brown, Edward James Cargill, Romain Fouquet, Jose Rafael Gomez, Matthew Sean Marengo, Manuel Oyervides Garcia, Jeanette M. Peevers, Dennis Hung Yang
  • Patent number: 10537379
    Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 21, 2020
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Michael B. Sano, Rafael V. Davalos, John L. Robertson, Paulo A. Garcia, Robert E. Neal
  • Patent number: 10513638
    Abstract: An adhesive composition comprising includes (i) a copolymer of an unsaturated hydrocarbon and an acrylate ester or acid, or of an unsaturated hydrocarbon and a vinyl saturated aliphatic ester or mixtures thereof, and (ii) a polyether carbonate polyol wherein the weight proportion of CO2 ranges from 0.5 to 37 wt % with respect to the total weight of the polyether carbonate polyol. The compositions of the invention may be used in PSA or HotMelt adhesive formulations.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: December 24, 2019
    Assignee: REPSOL, S.A.
    Inventors: Laura Marin Perales, Sonia Segura Fernandez, Carolina Ruiz Orta, Rafael Polo Abad, María Dolores Blanco Gonzalez, José Román Galdamez Peña, Mónica Garcia Ruiz
  • Publication number: 20190376055
    Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
    Type: Application
    Filed: August 8, 2019
    Publication date: December 12, 2019
    Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl, John L. Robertson, Robert E. Neal, II
  • Patent number: 10472684
    Abstract: The present disclosure is in the field of plant breeding. The disclosure provides methods for breeding corn plants having a brachytic trait using marker-assisted selection. The disclosure further provides brachytic germplasm, markers associated with a brachytic trait for introgressing the trait into elite germplasm in a breeding program. This disclosure also provides brachytic or dwarf elite corn varieties having yield equal to or higher than conventional non-brachytic corn varieties.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: November 12, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Ty Jason Barten, Alana N. Brown, Edward James Cargill, Romain Fouquet, Jose Rafael Gomez, Matthew Sean Marengo, Manuel Oyervides Garcia, Jeanette M. Peevers, Dennis Hung Yang
  • Patent number: 10470822
    Abstract: The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 12, 2019
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Paulo A. Garcia, Rafael V. Davalos
  • Patent number: 10443109
    Abstract: The present invention relates to a method for producing a hot-formed and quench-hardened tubular motor vehicle component (7) by way of internal high-pressure forming, a metallic starting material being at least partially heated to a heating temperature, in particular to a temperature above Ac3, being subjected to internal high-pressure forming in the hot state, and subsequently being quenched, preferably quench-hardened, wherein the internal high-pressure forming is performed as high-speed forming in a time of between 1 and 30 seconds, and the still-hot, formed motor vehicle component (7) is transferred into at least one separate quenching tool (5, 10) and is in particular quench-hardened, the motor vehicle component (7) being braced in a fixed position in the quenching tool (5, 10) and the cycle time of the quenching tool (5, 10) corresponding to the cycle time of the internal high-pressure forming.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: October 15, 2019
    Assignee: BENTLER AUTOMOBILTECHNIK GMBH
    Inventor: Rafael Garcia Gomez
  • Publication number: 20190300399
    Abstract: Disclosed are methods for aggregating suspended solid particles (e.g., kaolin) or dissolved solids in an aqueous medium, involving treating the aqueous medium with an effective amount of a flocculant (to aggregate the solids) to form aggregated solid particles or aggregated solids, and optionally separating the aggregated solid particles or aggregated solids from the aqueous medium; wherein the flocculant is a polymerized protein (e.g., polymerized hemoglobin or polymerized BSA which are proteins that have been polymerized by crosslinking).
    Type: Application
    Filed: February 22, 2019
    Publication date: October 3, 2019
    Inventors: Rafael A. Garcia, Christine M. Nieman, Matthew Essandoh
  • Publication number: 20190256839
    Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
    Type: Application
    Filed: May 6, 2019
    Publication date: August 22, 2019
    Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
  • Publication number: 20190233809
    Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
  • Publication number: 20190209452
    Abstract: The present invention relates to an exopolysaccharide-protein complex obtained from a bacterium comprising: (i) a crude exopolysaccharide, and (ii) exopolysaccharide-associated proteins which are derived from outer membrane vesicles and have a molecular weight between 30 and 250 kDa. The present invention further relates to a method for preparing said exopolysaccharide-protein complex and uses thereof.
    Type: Application
    Filed: September 19, 2017
    Publication date: July 11, 2019
    Inventors: Víctor Manuel DERONCELÉ THOMAS, Rafael MONTILLA AREVALO, Josep CASTELLS BOLIART, Adrián GARCÍA DE LA MARINA
  • Publication number: 20190193063
    Abstract: The present invention describes a process to prepare catalyst systems based on metal salts, supported on natural polymers and co-catalyzed by organic bases, for the catalytic transformation of carbon dioxide to organic carbonates through cycloaddition reactions to epoxides. The advantages of the presented system can be summarized on the use of raw materials of low cost for the preparation of the catalyst system, minimal environmental risk due to the low toxicity of the materials used, in some cases biodegradable such as the natural polymers, as well as high catalytic efficiency, reaching selectivities up to 100% and in some cases quantitative yields.
    Type: Application
    Filed: June 23, 2017
    Publication date: June 27, 2019
    Inventors: Heriberto DÍAZ VELÁZQUEZ, Rafael MARTÍNEZ PALOU, Javier GUZMÁN PANTOJA, Roberto GARCÍA DE LEÓN