Patents by Inventor Raffaele Ingenito

Raffaele Ingenito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190233494
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): Nter-Ac-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30—X31—X32—X33—NH2—Cter or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Olivier DUCLOS, Stéphane ILLIANO, Sergio MALLART, Claire MINOLETTI-HOCHEPIED, Elisabetta BIANCHI, Raffaele INGENITO, Paola MAGOTTI, Alessia SANTOPRETE
  • Publication number: 20190233493
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I): Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter; or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Denis Brasseur, Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Frank Marguet, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • Publication number: 20190233495
    Abstract: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO:65): Nter-X-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(X34)d-NH2-Cter It also concerns a pharmaceutical composition comprising at least one peptide of the invention, or a pharmaceutically acceptable salt or a solvate thereof, and the peptide, a pharmaceutically acceptable salt or solvate thereof, or the pharmaceutical composition, for its use as a medicament.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Stéphane ILLIANO, Sergio MALLART, Claire MINOLETTI-HOCHEPIED, Frank MARGUET, Olivier DUCLOS, Elisabetta BIANCHI, Raffaele INGENITO, Paola MAGOTTI, Alessia SANTOPRETE
  • Patent number: 8362030
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: January 29, 2013
    Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
    Inventors: Raffaele Ingenito, Philip Jones, Laura Llauger Bufi, Jesus Maria Ontoria Ontoria, Rita Scarpelli
  • Patent number: 8026265
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: September 27, 2011
    Assignee: Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA.
    Inventors: Philip Jones, Jesus Maria Ontoria Ontoria, Rita Scarpelli, Raffaele Ingenito, Carsten Schultz-Fademrecht
  • Publication number: 20110053911
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
    Type: Application
    Filed: March 13, 2009
    Publication date: March 3, 2011
    Inventors: Raffaele Ingenito, Philip Jones, Laura Llauger Bufi, Jesus Maria Ontoria Ontoria, Rita Scarpelli
  • Publication number: 20110046056
    Abstract: The invention relates to peptide mimetics for treating disorders associated with hypercholesterolemia and cardio-vascular disease. In particular, the invention relates to peptides that mimic the activity of apolipoprotein A-I (Apo AI).
    Type: Application
    Filed: June 18, 2008
    Publication date: February 24, 2011
    Inventors: Elisabetta Bianchi, Antonello Pessi, Raffaele Ingenito, Jun Wang, Ester Carballo-Jane, Ching H. Chang
  • Patent number: 7863294
    Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: January 4, 2011
    Assignee: Instituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA
    Inventors: Barbara Attenni, Federica Ferrigno, Philip Jones, Raffaele Ingenito, Olaf Kinzel, Laura Llauger Bufi, Jesus Maria Ontoria, Giovanna Pescatore, Michael Rowley, Rita Scarpelli, Carsten Schultz
  • Publication number: 20100234374
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
    Type: Application
    Filed: December 21, 2006
    Publication date: September 16, 2010
    Inventors: Philip Jones, Jesus Maria Ontoria Ontoria, Rita Scarpelli, Raffaele Ingenito, Carsten Schultz-Fademrecht
  • Publication number: 20090048228
    Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
    Type: Application
    Filed: December 9, 2005
    Publication date: February 19, 2009
    Inventors: Barbara Attenni, Federica Ferrigno, Philip Jones, Raffaele Ingenito, Olaf Kinzel, Laura Llauger Bufi, Jesus Maria Ontoria, Giovanna Pescatore, Michael Rowley, Rita Scarpelli, Carsten Schultz
  • Publication number: 20080262035
    Abstract: The present invention relates to carboxylic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
    Type: Application
    Filed: July 11, 2005
    Publication date: October 23, 2008
    Inventors: Prasun K. Chakravarty, Steven L. Colletti, Raffaele Ingenito, Peter T. Meinke, Alessia Petrocchi, Christian Steinkuhler
  • Publication number: 20080221157
    Abstract: The present invention relates to ketone derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
    Type: Application
    Filed: July 11, 2005
    Publication date: September 11, 2008
    Applicants: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE, MERCK & CO. INC.
    Inventors: Prasun K. Chakravarty, Steven L. Colletti, Raffaele Ingenito, Philip Jones, Peter T. Meinke, Ester Muraglia, Alessia Petrocchi, Michael Rowley, Rita Scarpelli, Christian Steinkuhler