Patents by Inventor Raffi Afeyan

Raffi Afeyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20240041810
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: March 8, 2023
    Publication date: February 8, 2024
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • METHODS FOR MODULATING INTESTINE CELLS OR TISSUE FUNCTION
    Publication number: 20230203158
    Abstract: Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in a desired cell, tissue and/or organ of interest while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbody™, that include an effector target binding domain specific for an effector target, and an address binding domain specific for an address target are described.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 29, 2023
    Inventors: Adrienne Marie ROTHSCHILDS, Nicholas McCartney Plugis, Charlotte Marie Nicod, Stephen Marshall, Avak Kahvejian, Yann Paul Guy Régis Echelard, Noubar Boghos Afeyan, Raffi Afeyan, Scott Moore Carlson, Vivek Kohar, Daniel Blom
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS
    Publication number: 20230105984
    Abstract: This disclosure provides combinations and methods for improving liver function, e.g., in a subject having a liver disease or disorder, or treating or preventing a liver disease or disorder, e.g., with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 6, 2023
    Inventors: Nadine Daou, William Comb, Alison Williams, Svetlana Marukian, Michael Hamill, Raffi Afeyan, Sean Carroll, Anthony Tramontin, Manu Chakravarthy
  • Amino acid compositions and their use for the treatment of traumatic brain injury
    Patent number: 11617731
    Abstract: This disclosure provides pharmaceutical compositions comprising defined amino acid components, and methods for treating traumatic brain injury comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 4, 2023
    Assignee: AXCELLA HEALTH, INC.
    Inventors: Sean Carroll, Raffi Afeyan, Gianluca De Rienzo, Matthew Russell
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11602511
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: March 14, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 11571404
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 7, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • COMPOSITIONS AND METHODS EXCLUDING OR WITH REDUCED GLUTAMINE FOR THE TREATMENT OF HEMOGLOBINOPATHIES AND THALASSEMIAS
    Publication number: 20230000808
    Abstract: This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or ?-thalassemia).
    Type: Application
    Filed: December 4, 2020
    Publication date: January 5, 2023
    Inventors: Revati Wani, Sean Carroll, Matthew Russell, Raffi Afeyan
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11129804
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 28, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES AND THALASSEMIAS
    Publication number: 20210290574
    Abstract: This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or ?-thalassemia).
    Type: Application
    Filed: June 8, 2021
    Publication date: September 23, 2021
    Inventors: Sean Carroll, Matthew Russell, Raffi Afeyan
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF INSULIN RESISTANCE AND METABOLIC CONDITIONS
    Publication number: 20210275479
    Abstract: This disclosure provides compositions and methods for reducing or treating insulin resistance in a subject.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 9, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, William Comb, Nadine Daou, Svetlana Marukian
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF FIBROSIS
    Publication number: 20210275480
    Abstract: This disclosure provides compositions and methods for reducing or treating fibrosis, e.g., in a subject having a fibrotic condition or disorder.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 9, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Luke S. Hamm, Svetlana Marukian, Nadine Daou
  • COMPOSITIONS AND METHODS FOR THE REDUCTION OR TREATMENT OF INFLAMMATION
    Publication number: 20210260010
    Abstract: This disclosure provides compositions and methods for reducing or treating inflammation, e.g., in a subject having an inflammatory condition or disorder.
    Type: Application
    Filed: June 19, 2019
    Publication date: August 26, 2021
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Simon Aoyama, Svetlana Marukian, Nadine Daou
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 11096914
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 24, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Compositions and methods for the treatment of hemoglobinopathies and thalassemias
    Patent number: 11058654
    Abstract: This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or ?-thalassemia).
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: July 13, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: Sean Carroll, Matthew Russell, Raffi Afeyan
  • Compositions and methods for the treatment of fat infiltration in muscle
    Patent number: 10973793
    Abstract: This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 13, 2021
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Michael Hamill, Raffi Afeyan
  • AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20200330417
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES AND DISORDERS ASSOCIATED WITH ONE OR BOTH OF HYPERAMMONEMIA OR MUSCLE WASTING
    Publication number: 20200306214
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Application
    Filed: April 15, 2020
    Publication date: October 1, 2020
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10682325
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 16, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • AMINO ACID COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY
    Publication number: 20200163919
    Abstract: This disclosure provides pharmaceutical compositions comprising defined amino acid components, and methods for treating traumatic brain injury comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 28, 2020
    Inventors: Sean Carroll, Raffi Afeyan, Gianluca De Rienzo, Matthew Russell
  • Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
    Patent number: 10660870
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: May 26, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill