Abstract: A medical device and a method of using same are provided. The medical device includes a first arm and a second arm mounted on a support rail, each of the first arm and the second arm having a bone contacting region. The medical device also includes a mechanism for reducing a distance between the bone contacting regions hereby applying a force to a bone or bones positioned therebetween and a force gauge for indicating a force applied by the bone contacting regions.

Abstract: A device for fixation of bone tissue and methods of using same are provided. The device includes a first anchor positionable within a first bone region, a second anchor positionable within a second bone region and a wire interconnecting the first and second anchors. The wire is attached to the first anchor via an elastically deformable element having a force constant (K) of 20-80 N/mm along a longitudinal axis of the first anchor.

Abstract: Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterlizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.

Abstract: Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterilizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.

Abstract: An electronically controlled, liquid-crystal eyeglass system is provided, designed for intermittent occlusion, while exercising the eyes of a user, through combined occlusion-and-exercising sessions, wherein the eyeglass system includes features to improve and monitor compliance. Specifically, features to improve compliance include an ordinary eyeglass design, wherein the electronic components are miniaturized and hidden, and a reflective coating on the exterior surfaces of the lenses, for identical exterior appearance, even when the two lenses operate at different opacity levels. In this manner, the liquid-crystal eyeglass system does not attract attention. Additionally, a fashionable design, and possibly also, a fashionable designer's brand name may be employed. In order to monitor compliance, the times, dates, and durations of the occlusion-and-exercising sessions that took place are recorded by the system.