Patents by Inventor Raheleh Toughiri

Raheleh Toughiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing Fabs and bi-specific antibodies
    Patent number: 10562982
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: February 18, 2020
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Stephen J Demarest, Xiufeng Wu, Raheleh Toughiri, Brian Arthur Kuhlman, Steven Morgan Lewis
  • Chemically-locked bispecific antibodies
    Patent number: 10435479
    Abstract: There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.
    Type: Grant
    Filed: May 10, 2015
    Date of Patent: October 8, 2019
    Assignee: Sorrento Therapeutics, Inc.
    Inventors: Yanwen Fu, Gunnar F. Kaufmann, Bryan Jones, Raheleh Toughiri
  • METHODS FOR PRODUCING FABS AND BI-SPECIFIC ANTIBODIES
    Publication number: 20190211115
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 11, 2019
    Inventors: Stephen J. Demarest, Xiufeng Wu, Raheleh Toughiri, Brian Arthur Kuhlman, Steven Morgan Lewis
  • Methods for producing fabs and bi-specific antibodies
    Patent number: 10294307
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 21, 2019
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Stephen J Demarest, Xiufeng Wu, Raheleh Toughiri, Brian Arthur Kuhlman, Steven Morgan Lewis
  • METHODS FOR PRODUCING FABS AND BI-SPECIFIC ANTIBODIES
    Publication number: 20180305466
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain light-chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Application
    Filed: July 6, 2018
    Publication date: October 25, 2018
    Inventors: Stephen J Demarest, Xiufeng Wu, Raheleh Toughiri, Brian Arthur Kuhlman, Steven Morgan Lewis
  • Methods for producing fabs and bi-specific antibodies
    Patent number: 10047167
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 14, 2018
    Assignees: Eli Lilly and Company, University of North Carolina at Chapel Hill
    Inventors: Stephen J Demarest, Xiufeng Wu, Brian Arthur Kuhlman, Steven Morgan Lewis, Raheleh Toughiri
  • CHEMICALLY-LOCKED BISPECIFIC ANTIBODIES
    Publication number: 20170260291
    Abstract: There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.
    Type: Application
    Filed: May 10, 2015
    Publication date: September 14, 2017
    Inventors: Yanwen Fu, Gunnar F. Kaufmann, Bryan Jones, Raheleh Toughiri
  • METHODS FOR PRODUCING FABS AND BI-SPECIFIC ANTIBODIES
    Publication number: 20160039947
    Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 11, 2016
    Inventors: Stephen J Demarest, Xiufeng Wu, Brian Arthur Kuhlman, Steven Morgan Lewis, Raheleh Toughiri