Patents by Inventor Rainer Figge

Rainer Figge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9051588
    Abstract: The present invention concerns a modified microorganism with an increased methylglyoxal reductase activity, and its use for the preparation of 1,2-propanediol and/or acetol. In particular this increased methylglyoxal reductase activity is obtained by increasing the expression of specific genes from microorganisms. This invention is also related to a method for producing 1,2-propanediol and/or acetol by fermentation of a microorganism having an increased methylglyoxal reductase activity.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: June 9, 2015
    Assignee: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Isabelle Meynial Salles, François Voelker, Rainer Figge
  • Patent number: 9034611
    Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: May 19, 2015
    Assignee: METALBOLIC EXPLORER
    Inventors: Wanda Dischert, Perrine Vasseur, Cédric Boisart, Rainer Figge
  • Patent number: 9023624
    Abstract: The present invention is related to a method for the fermentative production of hydroxymethionine, comprising the steps of: culturing a recombinant microorganism modified to produce methionine in an appropriate culture medium comprising a source of carbon, a source of sulfur and a source of nitrogen, recovering hydroxymethionine from the culture medium. In a specific embodiment, the recombinant microorganism is cultivated under conditions of nitrogen limitation. The invention is also related to the biologically-produced hydroxymethionine and its uses.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: May 5, 2015
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Wanda Dischert
  • Publication number: 20140342419
    Abstract: The present invention is related to a recombinant microorganism engineered for the production of 2,3-butanediol (BDO), wherein said microorganism overexpresses at least one gene encoding a polypeptide involved in the conversion of pyruvate into 2,3-butanediol. The invention is also related to a method of production of 2,3-butanediol comprising the following steps: providing a recombinant microorganism as described above, cultivating the recombinant microorganism in a culture medium containing a source of carbon, and recovering the 2,3-butanediol.
    Type: Application
    Filed: November 21, 2012
    Publication date: November 20, 2014
    Inventors: Wanda Dischert, Guillaume Letellier, Rainer Figge, Véronique Douchin
  • Patent number: 8795990
    Abstract: The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 5, 2014
    Assignee: Metabolic Explorer
    Inventors: Gwénaëlle Bestel-Corre, Michel Chateau, Rainer Figge, Céline Raynaud, Philippe Soucaille
  • Patent number: 8748136
    Abstract: The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: June 10, 2014
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Philippe Soucaille, Gwénaëlle Bestel-Corre
  • Publication number: 20140134680
    Abstract: The present invention is related to a recombinant microorganism for improved methionine production comprising modifications to produce methionine from glucose as main carbon source by fermentation, and modifications to improve glucose import, wherein the glucose import is improved by modifying the expression of at least one gene selected from ptsG, sgrT sgrS and dgsA. The invention is also related to a method for the fermentative production of methionine or methionine derivatives comprising the steps of: culturing the recombinant microorganism as described above in an appropriate culture medium comprising a fermentable source of carbon containing glucose and a source of sulphur, and recovering methionine or methionine derivatives from the culture medium.
    Type: Application
    Filed: June 29, 2012
    Publication date: May 15, 2014
    Inventors: Wanda Dischert, Rainer Figge
  • Publication number: 20140017740
    Abstract: The present invention is related to a method for the fermentative production of hydroxymethionine, comprising the steps of: culturing a recombinant microorganism modified to produce methionine in an appropriate culture medium comprising a source of carbon, a source of sulfur and a source of nitrogen, recovering hydroxymethionine from the culture medium. In a specific embodiment, the recombinant microorganism is cultivated under conditions of nitrogen limitation. The invention is also related to the biologically-produced hydroxymethionine and its uses.
    Type: Application
    Filed: December 30, 2010
    Publication date: January 16, 2014
    Applicant: METABOLIC EXPLORER
    Inventors: Rainer Figge, Wanda Dischert
  • Patent number: 8628967
    Abstract: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: January 14, 2014
    Assignee: Metabolic Explorer
    Inventors: Philippe Soucaille, Rainer Figge, Christian Croux
  • Publication number: 20130183727
    Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.
    Type: Application
    Filed: October 24, 2011
    Publication date: July 18, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Perrine Vasseur, Cedric Boisart, Rainer Figge
  • Publication number: 20130177956
    Abstract: The present invention is related to a population of Clostridium acetobutylicum useful for the production of 1,3-propanediol (PDO), wherein said population comprises at least one strain of a Clostridium acetobutylicum sp. comprising mutations selected among the mutations identified in table 1, wherein relative percentages of said mutations are selected among specific genes.
    Type: Application
    Filed: November 10, 2011
    Publication date: July 11, 2013
    Applicant: METABOLIC EXPLORER
    Inventor: Rainer Figge
  • Publication number: 20130089903
    Abstract: The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.
    Type: Application
    Filed: June 15, 2011
    Publication date: April 11, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Rainer Figge, Philippe Soucaille
  • Patent number: 8389250
    Abstract: A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives in which production of methionine or derivatives thereof, wherein the microorganism enhances production of cysteine.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: March 5, 2013
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Fabien Lux, Céline Raynaud, Michel Chateau, Philippe Soucaille
  • Publication number: 20120288904
    Abstract: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to ?-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.
    Type: Application
    Filed: December 29, 2010
    Publication date: November 15, 2012
    Applicant: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Gwenaelle Bestel-Corre, Guillaume Barbier, Rainer Figge
  • Publication number: 20120288903
    Abstract: The present invention relates to a process for improving the production of methionine by culturing a microorganism modified for enhancing the expression of genes involved in succinate dehydrogenase synthesis. The microorganisms were modified in a way that the methionine/carbon source yield is increased. The isolation of methionine from the fermentation medium is also claimed.
    Type: Application
    Filed: December 30, 2009
    Publication date: November 15, 2012
    Applicant: METABOLIC EXPLORER
    Inventor: Rainer Figge
  • Patent number: 8298807
    Abstract: The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of 1,2-propanediol from a carbon source. The said method comprises growing an initial strain under selection pressure in an appropriate growth medium, said initial bacterial strain comprising an attenuation of the expression of the tpiA gene and an attenuation the expression of at least one gene involved in the conversion of methylglyoxal to lactate, in order to promote evolution in said initial strain; then selecting and isolating the evolved strain having an increased 1,2 propanediol production rate; then reconstructing a functional tpiA gene in the evolved strain. The present invention also concerns the evolved strain such as obtained, that may be furthermore genetically modified in order to optimize the conversion of a carbon source into 1,2-propanediol without bv-products and with the best possible yield.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: October 30, 2012
    Assignee: Metabolic Explorer
    Inventors: Philippe Soucaille, Francois Voelker, Rainer Figge
  • Publication number: 20120252077
    Abstract: The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.
    Type: Application
    Filed: December 13, 2010
    Publication date: October 4, 2012
    Applicant: METABOLIC EXPLORER
    Inventors: Rainer Figge, Perrine Vasseur
  • Publication number: 20120190116
    Abstract: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes.
    Type: Application
    Filed: March 20, 2012
    Publication date: July 26, 2012
    Applicant: METABOLIC EXPLORER
    Inventors: Philippe SOUCAILLE, Rainer FIGGE, Christian CROUX
  • Patent number: 8168434
    Abstract: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: May 1, 2012
    Assignee: Metabolic Explorer
    Inventors: Philippe Soucaille, Rainer Figge, Christian Croux
  • Patent number: 8143031
    Abstract: The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: March 27, 2012
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Guillaume Barbier, Gwénaëlle Bestel-Corre