Patents by Inventor Ralph S. DaCosta
Ralph S. DaCosta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220248944Abstract: An endoscopic imaging device is disclosed. The device includes a body portion configured to be held in a user's hand and an endoscope portion configured to direct light onto a target. At least one excitation light source is configured to excite autofluorescence emissions of tissue cells and fluorescence emissions of induced porphyrins in tissue cells of the target. A white light source is configured to illuminate the surgical margin during white light imaging of the target. The device also includes an imaging sensor and a first optical filter configured to filter optical signals emitted by the target responsive to illumination with excitation light and permit passage of autofluorescence emissions of tissue cells and fluorescence emissions of the induced porphyrins in tissue cells to the imaging sensor.Type: ApplicationFiled: January 17, 2020Publication date: August 11, 2022Applicants: University Health Network, SBI ALAPHARMA CANADA INC.Inventors: Ralph S. DACOSTA, Kathryn OTTOLINO-PERRY, Christopher GIBSON, Nayana Thalanki ANANTHA, Simon TREADWELL, Todd DAYNES, Todd MEANEY, Garrett VERMEY, Carl ANNIS
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Publication number: 20220104706Abstract: An imaging device includes a body having a first end portion configured to be held in a user's hand and a second end portion configured to direct light onto a surgical margin. The device includes at least one excitation light source configured to excite autofluorescence emissions of tissue cells and fluorescence emissions of induced porphyrins in tissue cells of the surgical margin. A white light source is configured to illuminate the surgical margin during white light imaging of the surgical margin. The device includes an imaging sensor, a first optical filter configured to permit passage of autofluorescence emissions of tissue cells and fluorescence emissions of the induced porphyrins in tissue cells to the imaging sensor, and a second optical filter configured to permit passage of white light emissions of tissues in the surgical margin to the imaging sensor. Systems and methods relate to imaging devices.Type: ApplicationFiled: January 17, 2020Publication date: April 7, 2022Applicants: SBI ALAPHARMA CANADA INC., University Health NetworkInventors: Ralph S. DACOSTA, Kathryn OTTOLINO-PERRY, Christopher GIBSON, Nayana Thalanki ANANTHA, Simon TREADWELL, Todd DAYNES, Todd MEANEY, Garret VERMEY, Carl ANNIS
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Publication number: 20220108461Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of target such as a tumor or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.Type: ApplicationFiled: January 17, 2020Publication date: April 7, 2022Applicant: University Health NetworkInventors: Ralph S. DACOSTA, Kathryn OTTOLINO-PERRY, Christopher GIBSON
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Publication number: 20220092770Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.Type: ApplicationFiled: January 17, 2020Publication date: March 24, 2022Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph S. DaCosta, Danielle Dunham
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Publication number: 20220082500Abstract: A tissue phantom is disclosed. The tissue phantom includes a first portion having the optical properties of healthy tissue and a second portion having the optical properties of cancerous tissue. Additionally, a method of calibrating an optical instrument is disclosed. The method includes illuminating a tissue phantom with excitation light from the optical instrument, detecting optical emissions emitted by the tissue phantom in response to illumination with the excitation light, and calibrating the optical instrument based upon the detected fluorescence.Type: ApplicationFiled: January 17, 2020Publication date: March 17, 2022Applicant: University Health NetworkInventors: Ralph S. DACOSTA, Kathryn OTTOLINO-PERRY, Christopher GIBSON, Nayana Thalanki ANANTHA, Cristiana O'BRIEN
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Publication number: 20220061671Abstract: A portable, modular handheld imaging system is disclosed. The modular system comprises a first housing portion and a second housing portion. The first housing portion includes at least one excitation light source. A first filter is configured to detect and permit passage of selected optical signals responsive to illumination with the excitation light to a first image sensor. A second filter is configured to detect and permit passage of selected optical signals responsive to illumination of the target surface with white light to a second image sensor. The second housing portion is configured to releasably receive the first housing portion. The second housing portion includes a display and a processor configured to receive the detected fluorescent and white light optical signals and to output a representation of the target surface to the display based on the detected optical signals.Type: ApplicationFiled: January 17, 2020Publication date: March 3, 2022Applicant: MolecuLight Inc.Inventors: Ralph S. DACOSTA, Simon TREADWELL, Connor WRIGHT, Kimberlyn DAMPITAN, Todd DAYNES, Todd MEANEY, Carl ANNIS, Danielle DUNHAM, Nitesh MISTRY
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Publication number: 20220047164Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.Type: ApplicationFiled: October 25, 2021Publication date: February 17, 2022Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph S. DACOSTA, Brian C. WILSON, Kai ZHANG
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Publication number: 20220039656Abstract: A method of screening for contamination during food production is disclosed. The method includes applying an exogenous, bacteria-specific contrast agent to a surface to be screened, wherein the surface to be screened is one or more of a food product, a food-preparation surface, a food-handling surface, and a food-equipment surface. The surface is illuminated with excitation light emitted by at least one light excitation light source of a handheld device and optical signals responsive to illumination of the surface are filtered with at least one optical filter of the handheld device.Type: ApplicationFiled: August 20, 2021Publication date: February 10, 2022Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph S. DaCosta, Brian C. Wilson, Kai Zhang
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Publication number: 20210378518Abstract: A method for fluorescence-based imaging of a target to detect contamination and/or pollutants is disclosed. The method includes labelling a pre-selected biomarker at the target, illuminating the target with excitation light emitted by an excitation light source and having at least one wavelength or wavelength band causing at least the pre-selected biomarker to fluoresce, detecting fluorescence emissions of at least the pre-selected biomarker with an image detector of a handheld imaging device, and determining the presence, location, and/or quantity of contamination and/or pollutants on and/or in the illuminated target based on the detected fluorescence emissions of at least the pre-selected biomarker.Type: ApplicationFiled: August 20, 2021Publication date: December 9, 2021Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Brian C. Wilson, Kai Zhang
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Patent number: 11154198Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.Type: GrantFiled: July 5, 2018Date of Patent: October 26, 2021Assignee: UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Brian C. Wilson, Kai Zhang
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Publication number: 20180325377Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.Type: ApplicationFiled: July 5, 2018Publication date: November 15, 2018Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph S. DACOSTA, Brian C. WILSON, Kai ZHANG
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Publication number: 20160287211Abstract: Various embodiments are described herein for a method, apparatus and system for performing multi-modal imaging using a common imaging probe having various modes of operation including a fluorescent (FL) imaging mode and at least one of an ultrasound (US) imaging mode, a photoacoustic (PA) imaging mode and a combined US/PA imaging mode. Molecular/functional information may be obtained from FL and PA imaging and anatomical information may be obtained from ultrasound (US) imaging. The system may be implemented to provide for images from each modality in real time as well as provide for co-registration of these images. Experimental results demonstrate that combining the imaging modalities does not significantly compromise the performance of each of the separate US, PA, and FL imaging techniques, while enabling multi-modality registration.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Inventors: Ralph S. DaCosta, Brian C. Wilson, Israel Veilleux, Jin Ho Chang, Jeeun Kang, Yangmo Yoo, Tai-Kyong Song
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Patent number: D903863Type: GrantFiled: January 15, 2019Date of Patent: December 1, 2020Assignee: MolecuLight Inc.Inventors: Ralph S. Dacosta, Simon Treadwell, Sonia Gulia, Garrett Vermey, Danielle Dunham, Nitesh Mistry
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Patent number: D908161Type: GrantFiled: January 15, 2019Date of Patent: January 19, 2021Assignee: MOLECULIGHT, INC.Inventors: Ralph S. Dacosta, Simon Treadwell, Todd Daynes, Todd Meaney, Danielle Dunham, Carl Annis, Connor Wright, Kimberlyn Dampitan, Nitesh Mistry
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Patent number: D908881Type: GrantFiled: January 17, 2019Date of Patent: January 26, 2021Assignees: SBI ALAPHARMA CANADA, INC., UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Kathryn Ottolino-Perry, Christopher Gibson, Nayana Thalanki Anantha, Simon Treadwell, Todd Daynes, Todd Meaney
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Patent number: D910182Type: GrantFiled: January 17, 2019Date of Patent: February 9, 2021Assignees: SBI ALAPHARMA CANADA, INC., UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Kathryn Ottolino-Perry, Christopher Gibson, Nayana Thalanki Anantha, Simon Treadwell, Connor Wright, Kimberlyn Dampitan, Todd Daynes, Todd Meaney
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Patent number: D952023Type: GrantFiled: December 16, 2020Date of Patent: May 17, 2022Assignee: MOLECULIGHT, LTD.Inventors: Ralph S. Dacosta, Simon Treadwell, Todd Daynes, Todd Meaney, Danielle Dunham, Carl Annis, Connor Wright, Kimberlyn Dampitan, Nitesh Mistry
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Patent number: D958991Type: GrantFiled: January 26, 2021Date of Patent: July 26, 2022Assignees: SBI ALAPHARMA CANADA, INC., UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Kathryn Ottolino-Perry, Christopher Gibson, Nayana Thalanki Anantha, Simon Treadwell, Connor Wright, Kimberlyn Dampitan, Todd Daynes, Todd Meaney
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Patent number: D959666Type: GrantFiled: January 22, 2021Date of Patent: August 2, 2022Assignees: SBI ALAPHARMA CANADA, INC., UNIVERSITY HEALTH NETWORKInventors: Ralph S. Dacosta, Kathryn Ottolino-Perry, Christopher Gibson, Nayana Thalanki Anantha, Simon Treadwell, Todd Daynes, Todd Meaney
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Patent number: D1017040Type: GrantFiled: June 10, 2022Date of Patent: March 5, 2024Assignees: SBI ALAPHARMA CANADA, INC., University Health NetworkInventors: Ralph S. Dacosta, Kathryn Ottolino-Perry, Christopher Gibson, Nayana Thalanki Anantha, Simon Treadwell, Todd Daynes, Todd Meaney