Patents by Inventor Randolph Scott Ashton

Randolph Scott Ashton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10920193
    Abstract: Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: February 16, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ethan Scott Lippmann, Neha Sehgal, Randolph Scott Ashton
  • Publication number: 20200115677
    Abstract: Described herein are methods, compositions, and kits for forming engineered in vitro biomimetic, three-dimensional, tubular organoid structures by directed differentiation of human pluripotent stem cells within tubular channels formed in a hydrogel.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 16, 2020
    Inventors: Randolph Scott Ashton, Carlos Ruben Marti-Figueroa
  • Publication number: 20190024046
    Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 24, 2019
    Inventors: Randolph Scott Ashton, Gavin T. Knight
  • Publication number: 20170283774
    Abstract: Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.
    Type: Application
    Filed: March 31, 2017
    Publication date: October 5, 2017
    Inventors: Ethan Scott Lippmann, Neha Sehgal, Randolph Scott Ashton
  • Publication number: 20170157802
    Abstract: Described herein are sacrificial templates generated from water soluble thermoplastic-divalent cation-composite materials, such as poly(vinyl alcohol)-calcium. Also described herein are methods for the use of such sacrificial templates in casting of precise internal space microarchitectures within hydrogels, such as microchannel networks within alginate hydrogels.
    Type: Application
    Filed: December 7, 2015
    Publication date: June 8, 2017
    Inventors: Randolph Scott Ashton, Jason David McNulty, Carlos Ruben Marti-Figueroa, Lih-Sheng Turng
  • Publication number: 20160068806
    Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells into caudal lateral epiblasts, posterior neuroectoderm or posterior neuroepithelium, or motor neurons having specified HOX gene expression pattern mirroring a desired position along the rostral-caudal axis during hindbrain and spinal cord development. Also described are isolated populations of cells including caudal lateral epiblasts, posterior neuroectoderm, posterior neuroepithelium, or motor neurons having a HOX gene expression pattern specified to correspond to the HOX gene expression pattern associated with a desired rostral-caudal axis position.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 10, 2016
    Inventors: Randolph Scott Ashton, Ethan Scott Lippmann