Patents by Inventor Raphael J. Mannino

Raphael J. Mannino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080242625
    Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein.
    Type: Application
    Filed: April 11, 2005
    Publication date: October 2, 2008
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite
  • Publication number: 20040146551
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: November 3, 2003
    Publication date: July 29, 2004
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • Publication number: 20030228355
    Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
    Type: Application
    Filed: April 23, 2003
    Publication date: December 11, 2003
    Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
  • Patent number: 6592894
    Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: July 15, 2003
    Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
  • Patent number: 6165502
    Abstract: A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: December 26, 2000
    Assignees: Albany Medical College, Medical College of New Jersey
    Inventors: James M. Oleske, Thomas N. Denny, Anthony J. Scolpino, Eleonora Feketeova, Susan Gould-Fogerite, Raphael J. Mannino
  • Patent number: 5834015
    Abstract: A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: November 10, 1998
    Assignees: Albany Medical College, University of Medicine and Dentistry of New Jersey
    Inventors: James M. Oleske, Thomas N. Denny, Anthony J. Scolpino, Eleonora Feketeova, Susan Gould-Fogerite, Raphael J. Mannino
  • Patent number: 4871488
    Abstract: The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method has been exemplified with the use of glycoproteins of influenza (A/PR8/34) and Sendai (parainfluenza type I) viruses. The method comprises (A) extracting out the desired membrane protein from a source biological material with an extraction buffer comprising a detergent; (B) mixing the extract with a phospholipid solution and deriving a cochleate intermediate; and (C) forming large phospholipid vesicles with integrated membrane protein in a biologically active state.
    Type: Grant
    Filed: April 13, 1987
    Date of Patent: October 3, 1989
    Assignee: Albany Medical College of Union University
    Inventors: Raphael J. Mannino, Susan G. Fogerite
  • Patent number: 4663161
    Abstract: The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method has been exemplified with the use of glycoproteins of influenza (A/PR8/34) and Sendai (parainfluenza type I) viruses.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: May 5, 1987
    Inventors: Raphael J. Mannino, Susan G. Fogerite