Patents by Inventor Raphael Johannes GUEBELI

Raphael Johannes GUEBELI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CAMPHORSULFONIC ACID AND COMBINATIONS THEREOF WITH CATIONIC EXCIPIENTS AS VISCOSITY REDUCING AGENTS IN HIGH CONCENTRATED PROTEIN FORMULATIONS
    Publication number: 20220331430
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity, which is induced by the addition of at least camphorsulfonic acid. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.
    Type: Application
    Filed: September 16, 2020
    Publication date: October 20, 2022
    Applicant: MERCK PATENT GMBH
    Inventors: Tobias ROSENKRANZ, Raphael Johannes GUEBELI, Tanja HENZLER, Alexandra KROG, Christian HILDEBRANDT
  • METHOD FOR STABILIZING PROTEIN COMPRISING FORMULATIONS BY USING A MEGLUMINE SALT
    Publication number: 20210101929
    Abstract: The present invention relates to a method for stabilizing protein or peptide comprising formulations, which includes the step of adding selected meglumine salts to protein solutions, especially to solutions of pharmaceutical active proteins. But the present invention also relates to the stabilized composition comprising proteins or peptides and selected meglumine salts. Another objective of the present invention is to provide pharmaceutical compositions comprising antibody molecules stabilized by selected meglumine salts and methods for producing corresponding stabilized pharmaceutical compositions, and kit comprising these compositions.
    Type: Application
    Filed: April 16, 2019
    Publication date: April 8, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Christoph KORPUS, Raphael Johannes GUEBELI