Patents by Inventor Ravindra K. Pandey

Ravindra K. Pandey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220194952
    Abstract: Compounds for tumor imaging (e g , magnetic resonance (MR) and fluorescence) that may be used in combination with other methods to treat an individual having or suspected of having cancer (e.g., various forms of cancer, such as, for example, solid tumors). Compounds may have the following structure: (I) or a salt, a partial salt, a hydrate, a polymorph, an isomer (e.g., a structural or stereoisomer), or a mixture thereof, where R? is an aryl group or heteroaryl group having a halogen group (e.g., I or 124I), X is chosen from O, S, or NH, n is 1-6 (e.g., 1, 2, 3, 4, 5, or 6), the dotted carbon is chiral and is R or S.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 23, 2022
    Inventors: Ravindra K. PANDEY, Mykhaylo DUKH, Aimee MARKO, Munawwar SAJJAD
  • Patent number: 11083793
    Abstract: Compounds including a tetrapyrrolic or reduced tetrapyrrolic group/moiety and an epidermal growth factor receptor targeting group are disclosed. For example, a compound includes a tetrapyrrolic or reduced tetrapyrrolic group or moiety, a linker moiety, an epidermal growth factor receptor targeting group, and, optionally, a PET-active functional group. Uses of the compounds, for example, methods of treating a hyperproliferative tissue in an individual, and kits including one or more of the compounds are also provided.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: August 10, 2021
    Assignees: Health Research, Inc., Photolitec, LLC
    Inventors: Ravindra K. Pandey, Heinz Baumann, Khurshid Guru, Ravindra Cheruku, Erin Tracy, Farukh Durrani, Joseph Cacaccio, Kevin Siters
  • Publication number: 20200308184
    Abstract: The present disclosure provides compounds comprising a tetrapyrrole (e.g., a tetrapyrrole group) linked via a linker to one or more ligands and uses of the compounds. The compounds may be used as imaging agents (e.g., MRI contrast agents) or as both imaging and therapeutic agents. The compounds may be used to treat individuals in need of treatment for a hyperproliferative disorder, such as, for example, malignancy. The present disclosure also provides kits comprising pharmaceutical preparations containing any one or any combination of the compounds described herein.
    Type: Application
    Filed: September 21, 2018
    Publication date: October 1, 2020
    Inventors: Ravindra K. PANDEY, Zachary GROSSMAN, Ravindra CHERUKU, Joseph MISSERT, Joseph SPERNYAK, Craig M. HENDLER, Ronald A. ALBERICO, Sandra SEXTON, Farukh DURRANI
  • Publication number: 20200078461
    Abstract: Compounds including a tetrapyrrolic or reduced tetrapyrrolic group/moiety and an epidermal growth factor receptor targeting group are disclosed. For example, a compound includes a tetrapyrrolic or reduced tetrapyrrolic group or moiety, a linker moiety, an epidermal growth factor receptor targeting group, and, optionally, a PET-active functional group. Uses of the compounds, for example, methods of treating a hyperproliferative tissue in an individual, and kits including one or more of the compounds are also provided.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 12, 2020
    Inventors: Ravindra K. PANDEY, Heinz BAUMANN, Khurshid GURU, Ravindra CHERUKI, Erin TRACY, Farukh DURRANI, Joseph CACACCIO, Kevin SITERS
  • Publication number: 20200078459
    Abstract: Methods for treatment of cancer are provided. The methods are based on the use of both NIR photosensitizer(s) and chemotherapy agent(s). The NIR photosensitizers have a tetrapyrrolic core or reduced tetrapyrrolic core. Also provided are pharmaceutical compositions comprising NIR photosensitizer(s) and chemotherapy agent(s). Also provided are kits comprising NIR photosensitizer(s) and chemotherapy agent(s) and instructions for their use.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 12, 2020
    Inventors: Ravindra K. PANDEY, Farukh DURRANI, Khurshid GURU
  • Patent number: 10568963
    Abstract: A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: February 25, 2020
    Assignees: HEALTH RESEARCH, INC., HE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
  • Patent number: 9872903
    Abstract: A targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof is provided, which improves the selectivity of photosensitizers to tumor cells, has better tolerance, can reach maximum blood concentration in 24 hours, has a bigger conjugated system, a longer absorption wavelength and an advantage in treating depth tumors; the wavelength area does not need to consume much energy of a light-output device and even LEDs can be used, which render PDT more practical and economical. The targeting thymidine kinase photosensitizer can be used for diagnosis and for treating prostatic carcinoma via the guidance of fluorescence imaging. The pharmaceutical composition uses a combination of a chemotherapeutic agent and the targeting thymidine kinase photosensitizer, which further improves the therapeutic effect of the PDT method, expands the application range for tumors and has good effects on metastatic tumors as well.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: January 23, 2018
    Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD
    Inventors: Ravindra K Pandey, Yihui Chen, Hua Bai, Zhenliang Chen
  • Patent number: 9821062
    Abstract: Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2?? position, so that tumor highly absorbs the conjugates.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: November 21, 2017
    Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Ravindra K. Pandey, Nayan Patel, Manivannan Ethirajan, Hua Bai, Zhenliang Chen
  • Patent number: 9394253
    Abstract: The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating cell proliferative disorders, especially cancer.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: July 19, 2016
    Assignee: Health Research, Inc.
    Inventors: William G. Cance, Ravindra K. Pandey, Elena V. Kurenova, Manivannan Ethirajan
  • Publication number: 20160151494
    Abstract: A targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof is provided, which improves the selectivity of photosensitizers to tumor cells, has better tolerance, can reach maximum blood concentration in 24 hours, has a bigger conjugated system, a longer absorption wavelength and an advantage in treating depth tumors; the wavelength area does not need to consume much energy of a light-output device and even LEDs can be used, which render PDT more practical and economical. The targeting thymidine kinase photosensitizer can be used for diagnosis and for treating prostatic carcinoma via the guidance of fluorescence imaging. The pharmaceutical composition uses a combination of a chemotherapeutic agent and the targeting thymidine kinase photosensitizer, which further improves the therapeutic effect of the PDT method, expands the application range for tumors and has good effects on metastatic tumors as well.
    Type: Application
    Filed: November 2, 2012
    Publication date: June 2, 2016
    Inventors: RAVINDRA K PANDEY, YIHUI CHEN, HUA BAI, ZHENLIANG CHEN
  • Publication number: 20150329490
    Abstract: Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2?? position, so that tumor highly absorbs the conjugates.
    Type: Application
    Filed: February 6, 2013
    Publication date: November 19, 2015
    Inventors: Ravindra K. PANDEY, Hua BAI, Manivannan ETHIRAJAN, Nayan PATEL, Zhenliang CHEN
  • Patent number: 9155791
    Abstract: A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: October 13, 2015
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Heinz Baumann, Yihui Chen, Penny Joshi, Nayan Patel
  • Patent number: 9045488
    Abstract: A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: June 2, 2015
    Assignee: Photolitec, LLC
    Inventors: Ravindra K. Pandey, Anurag Gupta, Penny Joshi, Manivannan Ethirajan, Avinash Srivatsan
  • Publication number: 20150051245
    Abstract: The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating cell proliferative disorders, especially cancer.
    Type: Application
    Filed: November 13, 2012
    Publication date: February 19, 2015
    Inventors: William G. Cance, Ravindra K. Pandey, Elena V. Kurenova, Manivannan Ethirajan
  • Patent number: 8906343
    Abstract: A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: December 9, 2014
    Assignees: Health Research, Inc., The Research Foundation of State University of New York, Regents of the University of Michigan
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
  • Patent number: 8679459
    Abstract: Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: March 25, 2014
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Chao Liu, Mahabeer Dobhal, William Potter, Janet Morgan, Stephanie Pincus
  • Publication number: 20140081015
    Abstract: A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 20, 2014
    Applicant: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Heinz Baumann, Yihui Chen, Penny Joshi, Nayan Patel
  • Publication number: 20140011989
    Abstract: A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.
    Type: Application
    Filed: July 9, 2012
    Publication date: January 9, 2014
    Applicant: PHOTOLITEC, LLC
    Inventors: Ravindra K. Pandey, Anurag Gupta, Penny Joshi, Manivannan Ethirajan, Avinash Srivatsan
  • Patent number: 8609837
    Abstract: A compound in the form of a metallized tetrpyrollic photosensizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emmitance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: December 17, 2013
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Heinz Baumann, Yihui Chen, Penny Joshi, Nayan Patel
  • Patent number: 8562944
    Abstract: A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: October 22, 2013
    Assignees: Health Research, Inc., The Research Foundation of State University of NY, Regents of the University of Michigan
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad