Patents by Inventor Raymond J. Hughes

Raymond J. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11453655
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: September 27, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Patent number: 4883182
    Abstract: Plural chamber hard cap and body type capsules, each comprising two or more cooperational separately formed component capsules, dissimilar in transverse cross section, which are fixed in position relative to each other, having at least one inner component capsule positioned and fixed within an outer capsule; providing thereby plural chamber capsules, each having at least one transparent, clear, or translucent body part chamber to contain medicament or any other desired substance or device, and at least one other transparent, clear, or translucent body part chamber to contain a cooperational ingestible, disintegratable capsule insert device which is externally visible to the sighted user or consumer, providing thereby a tamper-evident capsule.
    Type: Grant
    Filed: January 12, 1988
    Date of Patent: November 28, 1989
    Inventor: Raymond J. Hughes
  • Patent number: 4627808
    Abstract: A hard capsule making apparatus consisting of cleft dipping pins, encircling stripping rings, and rotation discs having parallel grooved retainer bars, to provide a means for making and stripping novel integrally formed multiple chamber hard capsules, and a means for making and stripping novel multiple chamber hard capsules made by combining separate hard capsules of different sizes to form a single unit, fixed capsule within a capsule vehicle. The multiple chamber capsules are made of methylcellulose, gel, or other appropriate material, providing a clear, transparent, or translucent exterior wall of the body part of the multiple chamber capsule, thus providing an externally visible means for the consumer or user to detect, before use, whether the capsule has been opened after original filling and closure, by means of contrasting visible evidence of reopening, in the form of changed physical appearance of an original substance, or a substituted substance contained in at least one chamber thereof.
    Type: Grant
    Filed: May 31, 1985
    Date of Patent: December 9, 1986
    Inventor: Raymond J. Hughes
  • Patent number: 4191862
    Abstract: An interface between a telephone switch bus line and a dual tone multiple frequency (DTMF) type digital tone decoder is provided which minimizes false tone decoding due to filter-induced transient oscillations caused by spurious impulse noise and the like on the input bus line. The interface includes a limiter circuit for generating a uniform amplitude output pulse train and a circuit for automatically generating a variable threshold which is time responsive to input signals on the input bus line. The variable threshold circuit output signals are used by the limiter circuit to mask transient oscillations in the tone filter output. Only when persistence of the oscillations wherein the limiter threshold level signal is finally less than the peak amplitude of the input signals to the limiter from the tone filter will such input signals be sensed as valid switching tone signals.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: March 4, 1980
    Assignee: Rolm Corporation
    Inventor: Raymond J. Hughes