Patents by Inventor Raymond K. Houck
Raymond K. Houck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10323052Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: November 21, 2017Date of Patent: June 18, 2019Assignee: GRUNENTHAL GMBHInventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
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Publication number: 20180333425Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: ApplicationFiled: November 21, 2017Publication date: November 22, 2018Applicant: GRUNENTHAL GMBHInventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond K. HOUCK
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Publication number: 20170022226Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: ApplicationFiled: April 19, 2016Publication date: January 26, 2017Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond K. HOUCK
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Patent number: 9334296Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: March 14, 2013Date of Patent: May 10, 2016Assignee: THAR PHARMACEUTICALS, INC.Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
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Patent number: 8933057Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: February 13, 2013Date of Patent: January 13, 2015Assignee: Thar Pharmaceuticals, Inc.Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
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Publication number: 20140371112Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: ApplicationFiled: September 3, 2014Publication date: December 18, 2014Applicant: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 8859263Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: August 7, 2012Date of Patent: October 14, 2014Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 8445261Abstract: An apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises an imaging mechanism for automatically determining the state of an individual cell of the cells over time. The imaging mechanism is in communication with the incubating mechanism.Type: GrantFiled: January 7, 2011Date of Patent: May 21, 2013Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 8399023Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: July 30, 2010Date of Patent: March 19, 2013Assignee: Thar Pharmaceuticals, Inc.Inventors: Mazen Hanna, Ning Shan, Miranda Cheney, David Weyna, Raymond K. Houck
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Publication number: 20130023041Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: ApplicationFiled: August 7, 2012Publication date: January 24, 2013Inventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 8241892Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: April 2, 2002Date of Patent: August 14, 2012Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Publication number: 20110195055Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: ApplicationFiled: January 7, 2011Publication date: August 11, 2011Inventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Publication number: 20110028435Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: ApplicationFiled: July 30, 2010Publication date: February 3, 2011Applicant: THAR PHARMACEUTICALS, INC.Inventors: Mazen HANNA, Ning Shan, Miranda Cheney, David Weyna, Raymond K. Houck
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Patent number: 7867752Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: April 14, 1999Date of Patent: January 11, 2011Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 6830931Abstract: An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.Type: GrantFiled: October 26, 2001Date of Patent: December 14, 2004Assignee: Automated Cell, Inc.Inventors: Alfred Blalock Bahnson, Douglas J. Koebler, Charalambos N. Arthanassiou, Raymond K. Houck, Kris Sachsenmeier, Lei Qian
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Publication number: 20030082818Abstract: An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.Type: ApplicationFiled: October 26, 2001Publication date: May 1, 2003Applicant: Automated Cell, Inc.Inventors: Alfred Blalock Bahnson, Douglas J. Koebler, Charalambos N. Athanassiou, Raymond K. Houck, Kris F. Sachsenmeier, Lei Qian
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Publication number: 20020155487Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: ApplicationFiled: April 2, 2002Publication date: October 24, 2002Inventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 6008010Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled closed environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled closed environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: November 1, 1996Date of Patent: December 28, 1999Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 5954954Abstract: The present invention pertains to an apparatus for gathering analyte. The apparatus comprises a pumping mechanism for pumping solvent at supercritical pressure. The apparatus also comprises an extraction mechanism which receives a first sample and at least a second sample separate and distinct from the first sample and extract analyte from them essentially simultaneously. The extraction mechanism is connected to the pump mechanism to receive solvent at supercritical pressure for extracting the analyte from the samples. The apparatus additionally comprises a collection mechanism for collecting analyte from the solvent after the analyte has been extracted from the samples. The collection mechanism receives the supercritical solvent having the analyte extracted from the samples from the extraction mechanism. The present invention pertains to a method for extracting analyte. The method comprises the steps of pumping solvent at a supercritical pressure.Type: GrantFiled: June 20, 1997Date of Patent: September 21, 1999Assignee: Suprex CorporationInventors: Raymond K. Houck, Douglas J. Koebler, Glen P. Williams, Joseph M. Levy, Victor G. Danielson
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Patent number: 5866004Abstract: A supercritical fluid extraction (SFE) system. The SFE system includes a mechanism for providing supercritical fluid for extracting analyte from a sample. The SFE system also includes an extraction vessel and a mechanism for moving the extraction vessel into fluidic communication with the SFE system so that supercritical fluid can flow through the extraction vessel and extract analyte from the sample. Preferably, the SFE system is additionally comprised of a mechanism for holding a plurality of extraction vessels and an extraction chamber assembly. In this design, the moving mechanism selectively moves an extraction vessel from the holding mechanism into the extraction chamber in fluidic communication with the SFE system. Preferably, the SFE system further includes a computer for controlling the functions of the SFE system. The computer, for instance, could automatically and sequentially control the supercritical fluid extractions of the samples within the holding mechanism.Type: GrantFiled: September 8, 1995Date of Patent: February 2, 1999Assignee: Suprex CorporationInventors: Raymond K. Houck, Douglas J. Koebler, Glen P. Williams, Kenneth J. Kato, Robert D. Parks, Paul A. Bauer, Jr.