Patents by Inventor Raymond L. Houghton
Raymond L. Houghton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9989530Abstract: The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies.Type: GrantFiled: November 22, 2016Date of Patent: June 5, 2018Assignee: InBios International, Inc.Inventors: Syamal Raychaudhuri, Raymond L. Houghton, Stanislaw Morkowski, Yvonne Stevens, Mohua Bose, James William Needham, Hongjing Chen
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Publication number: 20170067895Abstract: The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies.Type: ApplicationFiled: November 22, 2016Publication date: March 9, 2017Applicant: InBios International, Inc.Inventors: Syamal Raychaudhuri, Raymond L. Houghton, Stanislaw Morkowski, Yvonne Stevens, Mohua Bose, James William Needham, Hongjing Chen
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Patent number: 9523686Abstract: The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies.Type: GrantFiled: December 10, 2014Date of Patent: December 20, 2016Assignee: InBios International, Inc.Inventors: Syamal Raychaudhuri, Raymond L. Houghton, Stanislaw Morkowski, Yvonne Stevens, Mohua Bose, James William Needham, Hongjing Chen
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Publication number: 20150086978Abstract: The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies.Type: ApplicationFiled: December 10, 2014Publication date: March 26, 2015Inventors: Syamal RAYCHAUDHURI, Raymond L. HOUGHTON, Stanislaw MORKOWSKI, Yvonne STEVENS, Mohua BOSE, James William NEEDHAM, Hongjing CHEN
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Patent number: 8920804Abstract: The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies.Type: GrantFiled: September 27, 2012Date of Patent: December 30, 2014Assignee: InBios International, Inc.Inventors: Syamal Raychaudhuri, Raymond L. Houghton, Stanislaw Morkowski, Yvonne Stevens, Mohua Bose, James William Needham, Hongjing Chen
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Patent number: 8173383Abstract: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.Type: GrantFiled: January 24, 2011Date of Patent: May 8, 2012Assignee: InBios International, Inc.Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Patent number: 8067016Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.Type: GrantFiled: June 24, 2009Date of Patent: November 29, 2011Assignee: Corixa CorporationInventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
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Patent number: 7982025Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.Type: GrantFiled: May 30, 2007Date of Patent: July 19, 2011Assignee: Corixa CorporationInventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
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Publication number: 20110159528Abstract: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.Type: ApplicationFiled: January 24, 2011Publication date: June 30, 2011Applicant: INBIOS INTERNATIONAL, INC.Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Publication number: 20110150883Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: June 23, 2011Applicant: CORIXA CORPORATIONInventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
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Patent number: 7695925Abstract: Compositions comprising fusion polypeptides of T. cruzi epitopes are provided, together with methods for the use of such compositions in the diagnosis of T. cruzi infection and in screening blood supplies. Diagnostic kits comprising such compositions are also provided.Type: GrantFiled: November 2, 2006Date of Patent: April 13, 2010Assignees: Inbios International, Inc., Infectious Disease Research InstituteInventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Publication number: 20090317841Abstract: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.Type: ApplicationFiled: December 6, 2006Publication date: December 24, 2009Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Publication number: 20090306195Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.Type: ApplicationFiled: June 24, 2009Publication date: December 10, 2009Applicant: Corixa CorporationInventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
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Publication number: 20080311123Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: December 18, 2008Applicant: CORIXA CORPORATIONInventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
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Publication number: 20080311124Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: December 18, 2008Applicant: CORIXA CORPORATIONInventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
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Publication number: 20080287362Abstract: Compositions comprising fusion polypeptides of T. cruzi epitopes are provided, together with methods for the use of such compositions in the diagnosis of T. cruzi infection and in screening blood supplies. Diagnostic kits comprising such compositions are also provided.Type: ApplicationFiled: November 2, 2006Publication date: November 20, 2008Applicants: InBios International, Inc., Infectious Disease Research InstituteInventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Publication number: 20080269151Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.Type: ApplicationFiled: May 30, 2007Publication date: October 30, 2008Applicant: Corixa CorporationInventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
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Publication number: 20080227739Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: September 18, 2008Applicant: CORIXA CORPORATIONInventors: Raymond L. Houghton, Paul R. Sleath, David H. Persing
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Publication number: 20080219989Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: September 11, 2008Applicant: CORIXA CORPORATIONInventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
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Publication number: 20080219982Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.Type: ApplicationFiled: October 30, 2007Publication date: September 11, 2008Applicant: CORIXA CORPORATIONInventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos