Patents by Inventor Rebecca Gottlieb
Rebecca Gottlieb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8086323Abstract: A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.Type: GrantFiled: September 23, 2003Date of Patent: December 27, 2011Assignee: Medtronic MiniMed, Inc.Inventors: Bahar Reghabi, Rebecca Gottlieb, Rajiv Shah, Bradley Enegren
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Patent number: 7912525Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.Type: GrantFiled: November 30, 2006Date of Patent: March 22, 2011Assignee: Medtronic Minimed, Inc.Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
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Publication number: 20110046457Abstract: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants.Type: ApplicationFiled: November 1, 2010Publication date: February 24, 2011Inventors: Rebecca Gottlieb, Rajiv Shah, Mary M. Morris, Victor Giron, Michael E. Miller, Bradley J. Enegren
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Patent number: 7833157Abstract: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants.Type: GrantFiled: May 15, 2008Date of Patent: November 16, 2010Assignee: Medtronic Minimed, Inc.Inventors: Rebecca Gottlieb, Rajiv Shah, Mary M. Morris, Victor Giron, Michael E. Miller, Bradley J. Enegren
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Patent number: 7634893Abstract: A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.Type: GrantFiled: August 8, 2008Date of Patent: December 22, 2009Assignee: Medtronic MiniMed, Inc.Inventors: Rebecca Gottlieb, Aaron Swanson, Bahar Reghabi, Kevin Branch
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Patent number: 7552522Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.Type: GrantFiled: August 26, 2004Date of Patent: June 30, 2009Assignee: Medtronic Minimed, Inc.Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
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Patent number: 7500949Abstract: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants.Type: GrantFiled: December 30, 2002Date of Patent: March 10, 2009Assignee: Medtronic Minimed, Inc.Inventors: Rebecca Gottlieb, Rajiv Shah, Mary M. Morris, Victor Giron, Michael E. Miller, Bradley J. Enegren
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Publication number: 20080289300Abstract: A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.Type: ApplicationFiled: August 8, 2008Publication date: November 27, 2008Inventors: Rebecca Gottlieb, Aaron Swanson, Bahar Reghabi, Kevin Branch
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Publication number: 20080221509Abstract: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants.Type: ApplicationFiled: May 15, 2008Publication date: September 11, 2008Inventors: Rebecca Gottlieb, Rajiv Shah, Mary M. Morris, Victor Giron, Michael E. Miller, Bradley J. Enegren
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Patent number: 7415811Abstract: A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.Type: GrantFiled: June 10, 2005Date of Patent: August 26, 2008Assignee: Medtronic Minimed, Inc.Inventors: Rebecca Gottlieb, Aaron Swanson, Bahar Reghabi, Kevin Branch
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Publication number: 20080064943Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.Type: ApplicationFiled: October 30, 2007Publication date: March 13, 2008Inventors: Cary Talbot, John Mastrototaro, Rajiv Shah, Edward Chernoff, John Mueller, Varaz Shahmirian, Richard Purvis, Wayne Morgan, Rebecca Gottlieb
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Publication number: 20070244383Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.Type: ApplicationFiled: May 7, 2007Publication date: October 18, 2007Applicant: Medtronic Minimed, Inc.Inventors: Cary Talbot, John Mastrototaro, Rajiv Shah, Edward Chernoff, John Mueller, Varaz Shahimirian, Richard Purvis, Wayne Morgan, Rebecca Gottlieb
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Publication number: 20070173711Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.Type: ApplicationFiled: September 23, 2005Publication date: July 26, 2007Applicant: Medtronic Minimed, Inc.Inventors: Rajiv Shah, Rebecca Gottlieb
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Patent number: 7247138Abstract: A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing material and a resealable insertion site coupled to one end of the site housing material. Preferably, the site housing material is formed to have an interior cavity with an opening. The site housing material is selected to promote tissue ingrowth and vascularization, and yet be free of tissue ingress. Also, the site housing material permits the analyte to pass through the site housing material to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site provides a for inserting the replaceable analyte sensor into the interior cavity of the site housing material.Type: GrantFiled: February 12, 2003Date of Patent: July 24, 2007Assignee: Medtronic MiniMed, Inc.Inventors: Bahar Reghabi, Rajiv Shah, Eunjoo Jin, Rebecca Gottlieb, Michael E. Miller, Nannette M. Van Antwerp, Bradley J. Enegren, William P. Van Antwerp, John J. Mastrototaro
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Publication number: 20070135698Abstract: Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.Type: ApplicationFiled: December 13, 2005Publication date: June 14, 2007Inventors: Rajiv Shah, Gopikrishnan Soundararajan, Rebecca Gottlieb, Udo Hoss, Eric Grovender, Shaun Pendo
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Publication number: 20070079836Abstract: A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.Type: ApplicationFiled: December 13, 2006Publication date: April 12, 2007Applicant: MEDTRONIC MINIMED, INC.Inventors: Bahar Reghabi, Rajiv Shah, Eunjoo Jin, Rebecca Gottlieb, Michael Miller, Nannette Van Antwerp, Bradley Enegren, William Van Antwerp, John Mastrototaro
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Publication number: 20070078319Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.Type: ApplicationFiled: November 30, 2006Publication date: April 5, 2007Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
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Publication number: 20070073129Abstract: A flexible mounting base to hold a sensor at an infusion site, the sensor being a removable in vivo sensor for monitoring analyte concentration level in a patient, such as blood glucose (BG) level. The mounting base comprises a flexible adhesive that anchors the flexible sensor set at an infusion site to provide stability for the sensor set in a convenient and comfortable manner. Placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn to leave the cannula and sensor at the selected insertion position, with the distal segment of the sensor being exposed to patient extracellular fluid via apertures formed in the cannula.Type: ApplicationFiled: September 23, 2005Publication date: March 29, 2007Applicant: Medtronic MiniMed, Inc.Inventors: Rajiv Shah, Rebecca Gottlieb, Eric Larson
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Patent number: 7166074Abstract: A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.Type: GrantFiled: June 2, 2003Date of Patent: January 23, 2007Assignee: Medtronic MiniMed, Inc.Inventors: Bahar Reghabi, Rajiv Shah, Eunjoo Jin, Rebecca Gottlieb, Michael E. Miller, Nannette M. Van Antwerp, Bradley J. Enegren, William P. Van Antwerp, John J. Mastrototaro
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Patent number: 7162289Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.Type: GrantFiled: December 31, 2002Date of Patent: January 9, 2007Assignee: Medtronic Minimed, Inc.Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller