Patents by Inventor Reinhard Schwartz

Reinhard Schwartz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9365824
    Abstract: Method for obtaining and expanding postembryonic hematopoietic stem cells from umbilical cord blood while avoiding unwanted differentiation. Initial cells from umbilical cord blood are proliferated and multiplied ex vivo in a stroma-free medium and in the presence of a regio-modified glycan or glycosaminoglycan. The regio-modified glycan or glycosaminoglycan, e.g. a heparin derivative, is N-desulfated, and N-reacetylated or N-reacylated, in essence, on C2 atoms. The heparin derivative advantageously comprises less than 5 percent of C3-O-sulfate, at least 60 percent C2-O-sulfate, and it is preferably added in a quantity of 15 to 50 mg/L to the medium in order to stop an unwanted differentiation. The stem cells generated in this manner can differentiate, after expansion, into myeloma cells and lymphatic cells, and they can be used as an immunotherapeutic agent against many diseases.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: June 14, 2016
    Assignee: IPD-THERAPEUTICS B.V.
    Inventors: Reinhard Schwartz-Albiez, Michael Punzel
  • Publication number: 20090004150
    Abstract: Method for obtaining and expanding postembryonic hematopoietic stem cells from umbilical cord blood while avoiding unwanted differentiation. Initial cells from umbilical cord blood are proliferated and multiplied ex vivo in a stroma-free medium and in the presence of a regio-modified glycan or glycosaminoglycan. The regio-modified glycan or glycosaminoglycan, e.g. a heparin derivative, is N-desulfated, and N-reacetylated or N-reacylated, in essence, on C2 atoms. The heparin derivative advantageously comprises less than 5 percent of C3-O-sulfate, at least 60 percent C2-O-sulfate, and it is preferably added in a quantity of 15 to 50 mg/L to the medium in order to stop an unwanted differentiation. The stem cells generated in this manner can differentiate, after expansion, into myeloma cells and lymphatic cells, and they can be used as an immunotherapeutic agent against many diseases.
    Type: Application
    Filed: March 31, 2005
    Publication date: January 1, 2009
    Inventors: Reinhard Schwartz-Albiez, Michael Punzel
  • Patent number: 4829646
    Abstract: A plug-in pump, which is controlled by a beveled edge, is inserted in a pump installation bore of the internal combustion engine with the aid of an adjusting arrangement and ensures a uniform feed quantity in all plug-in pumps of an engine without subsequent feed quantity adjustment. When the feed quantity adjusting element is fixed in the testing position, the plug-in pump, which is inserted in the test base, is rotated until the feed quantity corresponds to the desired feed quantity and a positioning peg of the adjusting arrangement, which is supported in the flange of the plug-in pump and received by a recess in the test base, is adjusted and fixed in this rotational position. When the control rod of the engine is blocked in the basic testing position, a positioning groove (33) of an adjusting plate (32) of the adjusting arrangement is put into a corresponding rotational position by means of a pump dummy.
    Type: Grant
    Filed: February 11, 1987
    Date of Patent: May 16, 1989
    Assignee: Robert Bosch GmbH
    Inventors: Jean-Pierre Cigolotti, Denis Devillierre, Jean Leblanc, Reinhard Schwartz
  • Patent number: 4690624
    Abstract: A fuel injection pump for internal combustion engines having a diversion bore disposed in the pump cylinder and controlled by a control edge on the pump piston. The diversion bore is embodied as a stepped bore having a segment of smaller diameter and a segment of larger diameter downstream of the segment in the flow direction. A liner which is not vulnerable to cavitation is disposed in the segment and is held in its working position by a resilient device, and a return flow conduit is formed between a chamber of lower pressure and an inlet to the bore of the liner.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: September 1, 1987
    Assignee: Robert Bosch GmbH
    Inventor: Reinhard Schwartz
  • Patent number: 4630587
    Abstract: The injection pump includes a pump cylinder, a pump piston moving into it and a hydraulic device for adjusting the instant of injection. The adjusting device has an adjusting cylinder, which is directed parallel to the pump cylinder and is accommodated in the housing of the injection pump, and adjusting piston and a restoring spring and adjusts a control sleeve, which opens the pump piston provided with at least one control recess in the longitudinal direction of the pump piston. This orientation and disposition of the adjusting cylinder effects a space-saving and inexpensive design of the injection pump and improves the precision of adjustment. The adjusting piston and the control sleeve may be directed coaxially and embodied as a single component, as a result of which a further space saving and increase in adjustment precision are attained.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: December 23, 1986
    Assignee: Robert Bosch GmbH
    Inventors: Gerald Hofer, Eberhard Hofmann, Helmut Laufer, Francois Rossignol, Reinhard Schwartz, Max Straubel, Raymond Tissot
  • Patent number: 4590903
    Abstract: A fuel injection apparatus for definite pilot and main injection in internal combustion engines. A hydraulic auxiliary pump is supplied via a pressure line with fuel from a high-pressure injection pump, which fuel reaches a main injection nozzle and simultaneously drives the hydraulic auxiliary pump. The hydraulic auxiliary pump contains a differential piston comprising a reservoir piston and a pilot injection piston with different diameters and with a spring prestressing such that between the end of supply of the pilot injection and the onset of supply of the main injection, an injection-free spacing stroke (DH) which can be predetermined by means of mechanical stops results, during which spacing stroke (DH) the reservoir piston by retracting further, receives the supply quantity which is pumped during the injection interval by the high-pressure injection pump.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: May 27, 1986
    Assignee: Robert Bosch GmbH
    Inventors: Eberhard Hofmann, Helmut Pfeifle, Reinhard Schwartz, Helmut Tschoeke
  • Patent number: 4546648
    Abstract: An arrangement for measuring of the injection quantity, the injection beginning and the injection end of individual injections of an intermittently operating injection pump, has an injection chamber, an adjustable throttle connectable with the injection chamber at one location, a movable wall limiting the injection chamber at another location against the counterforce, a path sensor arranged to receive the position of the movable wall and supply a signal for adjustment of throttle.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: October 15, 1985
    Assignee: Robert Bosch GmbH
    Inventors: Jurgen Abt, Dieter Handtmann, Reinhard Schwartz, Bertold Wocher
  • Patent number: 4543045
    Abstract: Each of the pump cylinders disposed in a line, of the fuel injection pump is surrounded in the vicinity of an overflow opening controlled by control edges of the pump piston by a partial suction chamber embodied as a hollow space. Each of these partial suction chambers is supplied with fuel, beginning at an inflow conduit via a throttled inflow opening and the fuel is carried away again via a return-flow opening into a return-flow conduit common to all the pump cylinders. Because of the crosswise flushing of each individual partial suction chamber the fuel temperature in these partial suction chambers is kept at least virtually constant, in order that identical fuel quantities will be supplied to the individual pump cylinders.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: September 24, 1985
    Assignee: Robert Bosch GmbH
    Inventors: Ernst Ritter, Reinhard Schwartz, Johann Warga
  • Patent number: 4530327
    Abstract: An electric control device in the form of a final control element for fuel injection pumps for internal combustion engines is protected in the interior of its housing from having the parts it contains inundated by lubricant originating in the interior of the injection pump. This protection is effected in that a suction device driven by the camshaft is disposed in the interior and aspirates lubricant originating in the injection pump and returns it then. The suction device has a rotating part driven by the camshaft, and at its lowest point in the sump it has a sliding shoe which under spring pressure rests at the rear on the rotating part and is so embodied that lubricant adhering to the rotating part reaches a gap and from there is transported back into the injection pump via a drainage hose containing a check valve.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: July 23, 1985
    Assignee: Robert Bosch GmbH
    Inventors: Martin Bohm, Manfred Kramer, Reinhard Schwartz
  • Patent number: 4526149
    Abstract: The fuel injection quantity of a fuel injection apparatus provided with a fuel injection pump is electrically regulated by means of the opening duration of a metering valve. Additionally, a shift in the instant of supply onset controlled in accordance with operating characteristics is attained by means of a change in the return-flow fuel quantity, which is diverted into a refill reservoir and then refilled completely into the pump work chamber by the beginning of the next subsequent injection stroke. Serving as the sole connection between the refill reservoir and a pump work chamber is an overflow conduit, the overflow opening of which, located at the discharge location into the pump work chamber, is opened by two control locations on the pump piston at the end of supply and once again shortly before bottom dead center.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: July 2, 1985
    Assignee: Robert Bosch GmbH
    Inventors: Walter Hafele, Helmut Pfeifle, Reinhard Schwartz, Max Straubel
  • Patent number: 4526150
    Abstract: The fuel injection quantity of a fuel injection apparatus provided with a fuel injection pump is electrically regulated by means of the opening duration of a metering valve. Additionally, a shift in the instant of supply onset controlled in accordance with operating characteristics is attained by means of a change in the return-flow fuel quantity, which is diverted into a refill reservoir and then refilled completely into the pump work chamber by the beginning of the next subsequent injection stroke. Serving as the sole connection between the refill reservoir and a pump work chamber is an overflow conduit, which is opened by two control locations on the pump piston at the end of a supply and shortly prior to the bottom dead center. Both the pump cylinder with the pressure valve and the refill reservoir and the metering valve are inserted in a leak-fuel-proof manner in a cylinder head of the pump housing, which is embodied in two parts.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: July 2, 1985
    Assignee: Robert Bosch GmbH
    Inventors: Josef Guntert, Walter Hafele, Helmut Pfeifle, Reinhard Schwartz, Max Straubel
  • Patent number: 4461256
    Abstract: The device has a scanning member, adjustable in relation to the rpm, for the determination of the full load injection amount and a support attachable to a base and holding a contour disk in a predetermined position, the latter serving as a stop for the scanning member. The support can be attached with the aid of a holding element in such a way, that the first adjustment position of the support equipped with the contour disk is permanently fixed. Even after the support has been removed, its renewed fixing in the first adjustment position is assured (FIG. 3).
    Type: Grant
    Filed: August 25, 1982
    Date of Patent: July 24, 1984
    Assignee: Robert Bosch GmbH
    Inventors: Werner Lehmann, Sieghart Maier, Reinhard Schwartz
  • Patent number: 4435128
    Abstract: A rotational body supported in a housing of the apparatus carries an angle indication marker, which serves as a signal trigger of a signal transducer secured in a positionally fixed manner relative to the housing of the rotational body. The signal transducer has a transducer body axially displaceably disposed in its transducer housing. This body is displaceable in the direction of its longitudinal axis in order to actuate a first contact switch, and is provided inside its other end face with a switch contact, cooperating with the angle indication marker, of a second contact switch. After the actuation of both contact switches, the angle indication marker is located in a predetermined rotary position, which is indicated in the associated test circuit and serves in particular to ascertain the supply onset position of the drive shaft of a fuel injection pump for internal combustion engines.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: March 6, 1984
    Assignee: Robert Bosch GmbH
    Inventors: Hansjorg Frey, Heinrich Hampel, Rolf Muller, Ernst Ritter, Reinhard Schwartz
  • Patent number: 4385867
    Abstract: An apparatus is proposed for positionally fixing a drive shaft disposed in a fuel injection pump for internal combustion engines in a predetermined rotary position, in particular one associated with the onset of fuel supply, and for measuring and testing this rotary position. The apparatus is provided with an apparatus into the reception bore of which either a holder element or an electric pulse transducer can be inserted. An element firmly connected with the drive shaft is provided with an angle-indicator marking, which is equipped both as a coupling element for the position-fixing apparatus and as a pulse trigger for the pulse transducer. The apparatus can thus be used both as a locking apparatus for mounting the injection pump on the engine and, with the pulse transducer inserted, as a measurement and testing apparatus.
    Type: Grant
    Filed: December 5, 1980
    Date of Patent: May 31, 1983
    Assignee: Robert Bosch GmbH
    Inventors: Max Straubel, Reinhard Schwartz, Ernst Ritter, Ilija Djordjevic
  • Patent number: 4348895
    Abstract: A method is proposed in which the injection pump, having been adjusted in terms of the supply quantity and of the supply onset, is provided on a test bench, before being mounted on the internal combustion engine, with an electric pulse transducer, whose mounted position is marked on the injection pump. The pump may also be corrected, at a fixed test rpm, to a set-point value fixed relative to the supply onset signal by means of measuring the signal distance between the supply onset signal of a signal transducer measuring the dynamic supply onset and the rotary-position signal of the pulse transducer. The injection pump, with the camshaft rotated into the rotary position associated with the dynamic supply onset, is mounted on the engine which has been brought with its crankshaft into the associated working position.
    Type: Grant
    Filed: December 5, 1980
    Date of Patent: September 14, 1982
    Assignee: Robert Bosch GmbH
    Inventors: Max Straubel, Reinhard Schwartz, Ernst Ritter, Ilija Djordjevic, Reinhard Doll
  • Patent number: 4305362
    Abstract: A centrigural rpm governor for fuel injected internal combustion engines is proposed in which an adaptor assembly located inside the governor can be used over the entire range of practical applications of such a governor. The governor includes parallel coextensive arms, a governor lever and a cooperative governor rod which has a counterstop provided with a sliding block that is movably disposed between the parallel coextensive arms against the initial stressing force of a spring member with the counterstop being arranged to cooperate with a stop means pivotally associated with the housing. The spring member is arranged to load the sliding block and adjustable for the purpose of varying the initial stress and setting the onset of adjustment.
    Type: Grant
    Filed: July 11, 1979
    Date of Patent: December 15, 1981
    Assignee: Robert Bosch GmbH
    Inventors: Reinhard Schwartz, Ernst Ritter, Rolf Muller, Werner Bruhmann
  • Patent number: 4286559
    Abstract: A pneumatic diaphragm control member is proposed for a fuel injection device for internal combustion engines, especially for a boost-pressure dependent full-load stop, wherein the initial and end positions of a push rod provided with a control diaphragm and movable against a resetting spring can be varied, and wherein the effective pressure range is variable by means of separate adjusting means which do not affect one another. The push rod of the diaphragm control member contacts, in the unpressurized starting position, a stop screw mounted in the lid cover, and, in the pressurized end position, is in contact, by means of a counter stop attached to an extension of the push rod and adjustable in the direction of motion of the push rod, with a second end stop arranged in the pressure chamber. Thus, the bias of the resetting spring can be changed by changing the position of a bearing bushing for the push rod, which bushing serves as an abutment.
    Type: Grant
    Filed: July 11, 1979
    Date of Patent: September 1, 1981
    Assignee: Robert Bosch GmbH
    Inventors: Ernst Ritter, Reinhard Schwartz, Rolf Muller, Martin Bohm
  • Patent number: 4281630
    Abstract: A centrifugal rpm governor for internal combustion engines in which the initial stressing of an adaptation spring is adjustable in a continuously variable manner in the installed state and without changing the spring stroke (b) determining the adaptation path. The governor includes an adaptation device disposed in the force transmitting path between a control member which adjusts in accordance with rpm and a force transmitting member subject to the force of the governor spring, which adaptation device includes in a recessed longitudinal bore, a stop bolt and an adaptation spring supported at one end by a ring screwed onto a threaded portion of the stop bolt, the ring being guided for axial displacement and provided with rotational securing means in the longitudinal bore so that by rotating the stop bolt a variation of the initial stressing of the adaptation spring in a continuously variable manner is possible without affecting the preset spring stroke (b).
    Type: Grant
    Filed: July 20, 1979
    Date of Patent: August 4, 1981
    Assignee: Robert Bosch GmbH
    Inventors: Werner Bruhmann, Reinhard Schwartz, Darsten Hummel
  • Patent number: 4258675
    Abstract: A regulator apparatus controlled by spring tension, such as a centrifugal governor for internal combustion engines wherein the spring characteristic of the regulator spring remains unchanged during operation and a regulator effectiveness which remains the same over a long period of time is attainable and which includes at least one compression spring acting as the regulator spring and inserted between two supports as well as an actuation member to transfer those regulator motions which tend to cause a change in length of the spring over onto the first spring end, which actuation member can tilt about a transverse shaft disposed perpendicularly to the longitudinal axis of the spring, the compression spring intentionally inserted into an installed position such that a point on the front face of the appropriate spring end, which point transfers the largest spring force component onto the spring support associated with the tiltable actuation member lies in a plane extending parallel to the longitudinal shaft of t
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: March 31, 1981
    Assignee: Robert Bosch GmbH
    Inventors: Werner Volz, Friedrich Russeler, Ernst Ritter, Reinhard Schwartz
  • Patent number: 4254753
    Abstract: A speed governor is proposed for fuel injected internal combustion engines capable of correcting the amount and/or mass of the injected fuel set by the governor, in order to maintain engine power at a fluctuating fuel temperature. The governor contains a supporting lever which retains the supporting pin of a control lever movable by the control member. The control lever is coupled with the fuel feed rate adjusting member of the injection pump, and the supporting lever is pivotable in the direction of an increase in the fuel feed rate, by means of a servo actuator of a correction device operating in dependence on the fuel temperature, when the fuel temperature rises. This correction step effective on the supporting lever also makes it possible to shut off the engine, independently of the fuel feed rate correction, by means of a shutoff lever effective on the supporting lever.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: March 10, 1981
    Assignee: Robert Bosch GmbH
    Inventors: Ernst Ritter, Reinhard Schwartz