Patents by Inventor Reinhold Mischler

Reinhold Mischler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220054059
    Abstract: This disclosure relates to a process for forming a membrane on an analyte sensor and further relates to an analyte sensor obtainable by this process. This disclosure also relates to a process for forming a sensing layer on an electrode of an analyte sensor and to an analyte sensor having the sensing layer obtainable by the inventive process as well as the membrane obtainable by the inventive process. The analyte sensors obtainable by the inventive processes may be used for conducting an analyte measurement of a body fluid of a user or a patient. This disclosure may be applied in the field of home care as well as in the field of professional care, such as in hospitals. Other applications are generally feasible.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 24, 2022
    Inventors: Peng Zou, Alexander Steck, Gernot Hochmuth, Reinhold Mischler, Kirill Sliozberg, Christian Hoertz
  • Publication number: 20190382819
    Abstract: The present invention relates to an enzymatic electrode comprising a conductive surface and wherein a conjugate comprising at least one enzyme molecule is covalently bound to the conductive surface. The electrode is suitable for continuous analyte monitoring, particularly for continuous glucose monitoring (CGM) with glucose oxidase (GOD) as enzyme molecule. Further, the invention relates to an electrochemical sensor for measuring the concentration of an analyte, e.g. glucose under in vivo conditions comprising the enzymatic electrode.
    Type: Application
    Filed: February 16, 2018
    Publication date: December 19, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Reinhold Mischler, Angelika Fuerst, Daniel Kam merer
  • Patent number: 10390743
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamecke, Ralph Gillen
  • Publication number: 20170290538
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: June 23, 2017
    Publication date: October 12, 2017
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Patent number: 9700252
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: July 11, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20170000396
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: August 2, 2013
    Publication date: January 5, 2017
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20160296151
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 13, 2016
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamacke, Ralph Dillen
  • Patent number: 9394563
    Abstract: An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: July 19, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ortrud Quarder, Arnulf Staib, Reinhold Mischler, Ewald Rieger, Ralph Gillen, Ulrike Kamecke
  • Publication number: 20150038814
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 5, 2015
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Patent number: 8871068
    Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 28, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
  • Patent number: 8527024
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 3, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Patent number: 8373851
    Abstract: A measuring system for determining blood glucose includes a photometric measuring unit with a light source and a detector, and an analytical test element, to which a body fluid sample can be applied, and which can be placed in a beam path between the light source and the detector for optical detection of an analyte. For an improved multi-wavelength measurement, it is proposed that the light source includes a first emitter that can be actuated in a first wavelength range to emit pulsating alternating light and a second emitter that can be excited in a second wavelength range to emit fluorescent light.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: February 12, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Joachim Hoenes, Frederic Wehowski, Reinhold Mischler, Herbert Harttig
  • Publication number: 20130003043
    Abstract: A measuring system for determining blood glucose includes a photometric measuring unit with a light source and a detector, and an analytical test element, to which a body fluid sample can be applied, and which can be placed in a beam path between the light source and the detector for optical detection of an analyte. For an improved multi-wavelength measurement, it is proposed that the light source includes a first emitter that can be actuated in a first wavelength range to emit pulsating alternating light and a second emitter that can be excited in a second wavelength range to emit fluorescent light.
    Type: Application
    Filed: July 2, 2012
    Publication date: January 3, 2013
    Inventors: Joachim Hoenes, Frederic Wehowski, Reinhold Mischler, Herbert Harttig
  • Patent number: 8160665
    Abstract: A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: April 17, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Reinhold Mischler, Gerhard Werner
  • Publication number: 20110196216
    Abstract: An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Application
    Filed: March 8, 2011
    Publication date: August 11, 2011
    Inventors: Ortrud Quarder, Arnulf Staib, Reinhold Mischler, Ewald Rieger, Ralph Gillen, Ulrike Kamecke
  • Publication number: 20090099433
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: December 19, 2008
    Publication date: April 16, 2009
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20090071846
    Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
    Type: Application
    Filed: July 18, 2008
    Publication date: March 19, 2009
    Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
  • Publication number: 20090054854
    Abstract: A microdialysis catheter for partial implantation is used to supply a perfusion fluid and remove a dialysate, such as glucose, and comprises a carrier, at least one opening in the carrier, and a non-porous coating over the opening. The carrier contains at least one channel for supplying a perfusion fluid and for removing a dialysate and an area intended for implantation. The opening on the carrier has a connection with the channel for the passage of fluid. The non-porous coating is externally bonded to the carrier. The non-poroous coating is diffusion-permeable to an analyte and covers the area intended for implantation and the opening. A process for manufacturing the microdialysis catheter is also disclosed.
    Type: Application
    Filed: August 21, 2008
    Publication date: February 26, 2009
    Inventors: Gernot Hochmuth, Reinhold Mischler
  • Publication number: 20070191696
    Abstract: A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.
    Type: Application
    Filed: February 16, 2007
    Publication date: August 16, 2007
    Inventors: Reinhold Mischler, Gerhard Werner
  • Publication number: 20050158867
    Abstract: The present invention discloses a method and a system for screening biological samples for the presence of a metabolic syndrome in a sample donor.
    Type: Application
    Filed: January 14, 2003
    Publication date: July 21, 2005
    Inventors: Wolfgang Petrich, Gerhard Werner, Reinhold Mischler, Johanna Frueh, Stephan Jacob