Abstract: A system for preparing a calibrated volume of blood plasma that includes a plurality of parts: a device for preparing the calibrated volume of blood plasma, which is in the form of a single card; a pneumatic-type actuating system SP; a treatment and command unit UC configured such as to execute a command sequence of different pneumatic command points of the pneumatic actuation system with a view to obtaining, from a taken blood sample, the calibrated volume of blood plasma. The device includes three distinct modules: a fluidic connection module M1 onto which a blood sampling device may be connected; a module M2 for separation of the blood plasma contained in the blood sample; a module M3 for obtaining at least one calibrated volume of blood plasma, after separation.

Abstract: An automated system for preparing, detecting and analyzing a first fluid sample containing biological species, the preparation, detection and analysis system including at least one fluidic cartridge that includes at least one fluidic concentration and lysis module and one fluidic detection module including an array of several amplification chambers arranged in parallel, an apparatus including a mechanical assembly comprising at least one movable rod fastened to the frame and comprising a free end arranged to cooperate with a flexible membrane of the fluidic concentration and lysis module, an optical measurement system for measuring fluorescence through one or more amplification chambers of the fluidic detection module of the cartridge, a control and processing unit.

Abstract: A system for preparing a calibrated volume of blood plasma that includes a plurality of parts: a device for preparing the calibrated volume of blood plasma, which is in the form of a single card; a pneumatic-type actuating system SP; a treatment and command unit UC configured such as to execute a command sequence of different pneumatic command points of the pneumatic actuation system with a view to obtaining, from a taken blood sample, the calibrated volume of blood plasma. The device includes three distinct modules: a fluidic connection module M1 onto which a blood sampling device may be connected; a module M2 for separation of the blood plasma contained in the blood sample; a module M3 for obtaining at least one calibrated volume of blood plasma, after separation.

Abstract: A device and method for lysing biological species present in a fluid includes implementing a rough surface against which the objects to be lysed are crushed by a shearing motion. A device for mechanically lysing biological species has a first and second wall mounted movable relative to each other, between an initial position in which the walls are separated from each other, and a lysing position in which the first wall presses against the second wall. The first and second walls also are mounted shearingly movable relative to each other in the lysing position. At least one of the first or second walls has a rough bearing surface against the other wall and has a mean surface roughness parameter Ra of between 0.2 ?m and 10 ?m, and preferably between 0.2 ?m and 3 ?m.

Abstract: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

Abstract: A device and method for lysing biological species present in a fluid includes implementing a rough surface against which the objects to be lysed are crushed by a shearing motion. A device for mechanically lysing biological species has a first and second wall mounted movable relative to each other, between an initial position in which the walls are separated from each other, and a lysing position in which the first wall presses against the second wall. The first and second walls also are mounted shearingly movable relative to each other in the lysing position. At least one of the first or second walls has a rough bearing surface against the other wall and has a mean surface roughness parameter Ra of between 0.2 ?m and 10 ?m, and preferably between 0.2 ?m and 3 ?m.

Abstract: The invention relates to a method and an apparatus (100) for the enrichment of magnetic particles (1) in a sample fluid. The sample fluid is provided in a sample cartridge (2) between a first pole (111) and a second pole (112) of an actuator magnet (110). A minimal magnetic flux as well as a minimal magnetic gradient are then established inside the sample fluid, wherein their values depend on the particular magnetic particles (1) and the sample fluid under consideration. In a preferred embodiment, the first pole (111) has a single tip (T).

Abstract: The invention relates to a method and an apparatus (100) for the enrichment of magnetic particles (1) in a sample fluid. The sample fluid is provided in a sample cartridge (2) between a first pole (111) and a second pole (112) of an actuator magnet (110). A minimal magnetic flux as well as a minimal magnetic gradient are then established inside the sample fluid, wherein their values depend on the particular magnetic particles (1) and the sample fluid under consideration. In a preferred embodiment, the first pole (111) has a single tip (T).

Abstract: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.