Patents by Inventor Remy F. Gross, III

Remy F. Gross, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9333267
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: May 10, 2016
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20150224207
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.
    Type: Application
    Filed: April 23, 2015
    Publication date: August 13, 2015
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 9040658
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 26, 2015
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20140330041
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Application
    Filed: March 28, 2014
    Publication date: November 6, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8835556
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: September 16, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8722032
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: May 13, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8304511
    Abstract: The present invention is directed a method comprising administering a composition to an individual, wherein the composition comprises a plurality of conjugates, each conjugate in the plurality a protein derivatized with a water-soluble polymer, wherein the polymer is coupled to the protein via succinimide groups covalently attached to either cysteine sulfhydryl groups or lysine amino groups, and substantially all of the succinimide groups present in the composition are present in a ring-opened form.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: November 6, 2012
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20120226022
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8227555
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: July 24, 2012
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20120123065
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Application
    Filed: December 23, 2011
    Publication date: May 17, 2012
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8106131
    Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: January 31, 2012
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20110262379
    Abstract: The present invention is directed a method comprising administering a composition to an individual, wherein the composition comprises a plurality of conjugates, each conjugate in the plurality a protein derivatized with a water-soluble polymer, wherein the polymer is coupled to the protein via succinimide groups covalently attached to either cysteine sulfhydryl groups or lysine amino groups, and substantially all of the succinimide groups present in the composition are present in a ring-opened form.
    Type: Application
    Filed: June 29, 2011
    Publication date: October 27, 2011
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 7994272
    Abstract: The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 9, 2011
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 7910661
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: March 22, 2011
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20110034643
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Application
    Filed: October 21, 2010
    Publication date: February 10, 2011
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20100113329
    Abstract: The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
    Type: Application
    Filed: December 18, 2009
    Publication date: May 6, 2010
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 7659361
    Abstract: The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: February 9, 2010
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20090012241
    Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Application
    Filed: August 26, 2008
    Publication date: January 8, 2009
    Applicant: Nektar Therapeutics AL, Corporation
    Inventors: Antoni Kozlowski, Remy F. Gross III, Samuel P. McManus
  • Patent number: 7432330
    Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: October 7, 2008
    Assignee: Nektar Therapeutics AL, Corporation
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 7432331
    Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: October 7, 2008
    Assignee: Nektar Therapeutics AL, Corporation
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus