Patents by Inventor Rene A. Molina

Rene A. Molina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11857790
    Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device determines a first set of stimulation parameters that define entrainment stimulation pulses configured to entrain electrical activity in a patient. The medical device may control a stimulation generator to generate the entrainment stimulation pulses according to the first set of stimulation parameters. The medical device may further determine a second set of stimulation parameters that define at least one desynchronization stimulation pulse configured to disrupt at least a portion of the electrical activity entrained by the entrainment stimulation pulses. The medical device may subsequently control the stimulation generator to generate the desynchronization stimulation pulse(s) according to the second set of stimulation parameters.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: January 2, 2024
    Assignee: Medtronic, Inc.
    Inventors: Rene A Molina, Robert S. Raike, Scott R. Stanslaski
  • Publication number: 20230347152
    Abstract: A system for closed-loop therapy includes memory configured to store a first set of one or more parameters for a first set of therapeutic electrical stimulation signals. The system includes processing circuitry configured to determine one or more local field potential (LFP) measurements of an LFP that is intrinsically generated, cause stimulation generation circuitry to deliver one or more electrical stimulation signals, determine one or more evoked resonant neural activity (ERNA) signals that are evoked by delivery of respective ones of the electrical stimulation signals, determine a second set of one or more parameters for a second set of therapeutic electrical stimulation signals based on the one or more evoked signals and the one or more LFP measurements, and cause the stimulation generation circuitry to deliver the second set of the one or more therapeutic electrical stimulation signals.
    Type: Application
    Filed: April 26, 2023
    Publication date: November 2, 2023
    Inventors: Kristin N. Hageman, Scott R. Stanslaski, Erik J. Peterson, Rene A. Molina, Paul H. Stypulkowski, David A. Dinsmoor, Leonid M. Litvak
  • Publication number: 20230263444
    Abstract: Systems and methods for programming an implantable medical device comprising a simulated environment with at least one lead having a plurality of electrodes, computing hardware of at least one processor and a memory operably coupled to the at least one processor, and instructions that, when executed on the computing hardware, cause the computing hardware to implement a training sub-system configured to conduct a brain sense survey using the simulated environment, develop at least one machine learning model based on the brain sense survey, apply the at least one machine learning model to in-vivo patient data to determine at least one predicted electrode from the plurality of electrodes relative to an oscillatory source, visualize the at least one predicted electrode, and program a medical device based on the at least one predicted electrode.
    Type: Application
    Filed: January 26, 2023
    Publication date: August 24, 2023
    Inventors: Michelle A. Case, Eric J. Panken, Rene A. Molina, Paula A.E. Dassbach Green, Abbey Beuning Holt Becker
  • Publication number: 20230241400
    Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
    Type: Application
    Filed: April 10, 2023
    Publication date: August 3, 2023
    Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L. Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker
  • Publication number: 20230166111
    Abstract: A system includes memory and processing circuitry coupled to the memory and configured to determine a plurality of local field potential (LFP) measurements of an LFP, wherein the LFP is intrinsically generated by a signal source within a brain of a patient, determine one or more electrodes for delivering a therapeutic electrical stimulation signal based on the LFP measurements, control stimulation generation circuitry to deliver a plurality of electrical stimulation signals via the determined one or more electrodes, wherein the plurality of electrical stimulation signals each comprise at least one different therapy parameter, for respective ones of the plurality of electrical stimulation signals, determine respective evoked signals, wherein the respective evoked signals are evoked by delivery of the respective plurality of electrical stimulation signals, and determine at least one parameter for the therapeutic electrical stimulation signal based on the respective evoked signals.
    Type: Application
    Filed: October 31, 2022
    Publication date: June 1, 2023
    Inventors: Kristin N. Hageman, Scott R. Stanslaski, Erik J. Peterson, Rene A. Molina, Paul H. Stypulkowski, David A. Dinsmoor, Leonid M. Litvak, Michelle A. Case
  • Publication number: 20230110685
    Abstract: This disclosure is directed to devices, systems, and techniques for delivering electrical stimulation. In some examples, a system includes processing circuitry configured to: receive information representative of a bioelectric brain signal recorded from a brain of a patient; and determine, based on the information, at least one pathological frequency of the bioelectric brain signal. Additionally, the processing circuitry is configured to select, based on the at least one pathological frequency, a sequence of pulse bursts at a pulse burst frequency, the sequence of pulse bursts at least partially defining electrical stimulation deliverable to an area of a brain of a patient, wherein adjacent pulse bursts within the sequence comprise different intra-burst pulse frequencies; and control a medical device to deliver the electrical stimulation comprising the sequence of pulse bursts to the area of the brain of the patient.
    Type: Application
    Filed: September 22, 2022
    Publication date: April 13, 2023
    Inventors: Rene A. Molina, Abbey Beuning Holt Becker
  • Patent number: 11623096
    Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: April 11, 2023
    Assignee: Medtronic, Inc.
    Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L. Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker
  • Publication number: 20230092658
    Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive information representing a plurality of signals sensed from a tissue of a patient via a plurality of electrode combinations, wherein the plurality of electrode combinations comprises different electrode combinations comprising electrodes disposed at different positions of the lead implanted in the patient, determine one or more features from the information representing the plurality of signals, and compare the one or more features to a plurality of templates, each template of the plurality of templates representing respective locations of a signal source within the tissue. The system may then determine, based on the comparison of the one or more features to the plurality of templates, an estimated location of the signal source with respect to the lead.
    Type: Application
    Filed: August 24, 2021
    Publication date: March 23, 2023
    Inventors: Jadin C. Jackson, Eric J. Panken, Michelle A. Case, Rene A. Molina, Abbey Beuning Holt Becker, Christopher L. Pulliam
  • Publication number: 20230069981
    Abstract: An example system includes stimulation generation circuitry configured to deliver electrical stimulation to a patient; sensing circuitry configured to sense one or more biomarker signals; and processing circuitry configured to: cause delivery of electrical stimulation with the patient in a first patient state; receive a first instance of a biomarker signal in presence of the electrical stimulation with the patient in the first patient state; cause delivery of electrical stimulation with the patient in a second patient state; receive a second instance of the biomarker signal in presence of the electrical stimulation with the patient in the second patient state; determine whether a difference between the first instance of the biomarker signal and the second instance of the biomarker signal satisfies a threshold; select a therapy mode based on whether the difference satisfies the threshold; and cause delivery of electrical stimulation in accordance with the selected therapy mode.
    Type: Application
    Filed: August 8, 2022
    Publication date: March 9, 2023
    Inventors: Benjamin P. Isaacson, Scott R. Stanslaski, Abbey Beuning Holt Becker, Rene A. Molina, Caleb C. Zarns, David E. Linde, Nicholas D. Buse, Thaddeus S. Brink
  • Publication number: 20220409881
    Abstract: Implantable medical leads include rows of electrode segments where electrode segments within a given row may be a different size and/or adjacent electrode segments of adjacent rows may be of a different size. The arrangement of the electrode segments of different sizes may avoid intersections of the spaces between segments to reduce the size and/or number of blind spots that otherwise occur for delivery of stimulation signals and/or sensing of physiological signals. The electrode segments of different sizes may be of a same shape type but with different proportions.
    Type: Application
    Filed: June 22, 2022
    Publication date: December 29, 2022
    Inventors: Rene A. Molina, Michelle A. Case, Paula A. Dassbach, Abbey B.H. Becker, Christopher L. Pulliam
  • Publication number: 20220266031
    Abstract: An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.
    Type: Application
    Filed: February 16, 2022
    Publication date: August 25, 2022
    Inventors: Benjamin P. Isaacson, David E. Linde, Scott R. Stanslaski, Christopher L. Pulliam, Rene A. Molina, Abbey Beuning Holt Becker, David L. Carlson, Nicholas D. Buse, Duane L. Bourget, Thaddeus S. Brink
  • Publication number: 20220266032
    Abstract: A medical device for providing electrical stimulation to a brain of a patient includes one or more processors. The one or more processors are configured to determine a first set of parameters of a first electrical signal that is delivered via a first electrode configured to apply electrical stimulation to a first region of the brain and to determine a second set of parameters of a second electrical signal based on the first set of parameters. The second electrical signal is delivered via a second electrode configured to apply electrical stimulation to a second region of the brain. The one or more processors are further configured to deliver, with the first electrode, the first electrical signal having the first set of parameters and to deliver, with the second electrode, the second electrical signal having the second set of parameters.
    Type: Application
    Filed: February 21, 2022
    Publication date: August 25, 2022
    Inventors: Rene A. Molina, Robert S. Raike, Benjamin P. Isaacson, Christopher L. Pulliam, Abbey Beuning Holt Becker, Michelle A. Case
  • Publication number: 20220266033
    Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive, for each electrode combination of a plurality of electrode combinations, information representing a signal sensed in response to first electrical stimulation delivered to a patient via a lead, wherein the plurality of electrode combinations comprise different electrode combinations comprising electrode disposed at different positions around a perimeter of the lead implanted in the patient. The system may also be configured to determine, based on the information for each electrode combination of the plurality of electrode combinations, values for a threshold at different locations around the perimeter of the lead and determine, based on the values for the threshold, one or more stimulation parameter values that at least partially define second electrical stimulation deliverable to the patient via the lead.
    Type: Application
    Filed: February 17, 2022
    Publication date: August 25, 2022
    Inventors: Jadin C. Jackson, Rene A. Molina, Christopher L. Pulliam
  • Publication number: 20220249846
    Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device determines a first set of stimulation parameters that define entrainment stimulation pulses configured to entrain electrical activity in a patient. The medical device may control a stimulation generator to generate the entrainment stimulation pulses according to the first set of stimulation parameters. The medical device may further determine a second set of stimulation parameters that define at least one desynchronization stimulation pulse configured to disrupt at least a portion of the electrical activity entrained by the entrainment stimulation pulses. The medical device may subsequently control the stimulation generator to generate the desynchronization stimulation pulse(s) according to the second set of stimulation parameters.
    Type: Application
    Filed: February 28, 2022
    Publication date: August 11, 2022
    Inventors: Rene A. Molina, Robert S. Raike, Scott R. Stanslaski
  • Patent number: 11376434
    Abstract: Devices, systems, and techniques are configured for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: July 5, 2022
    Assignee: Medtronic, Inc.
    Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L. Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker
  • Publication number: 20220169701
    Abstract: A recombinant fusion protein is disclosed. The fusion protein comprises: (a) a CD55 peptide sequence, (b) a linker sequence C-terminal to the CD55 sequence, (c) a transmembrane domain C-terminal to the linker sequence, and (d) an intracellular domain C-terminal to the transmembrane domain. The fusion protein does not contain a GPI anchor. The fusion protein can be expressed with an N-terminal secretory signal peptide, which is cleaved to yield the mature protein on the surface of a cell line or an enveloped virus. An oncolytic virus expressing the fusion protein is resistant to complement inactivation and can be used to treat cancer.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Tianci LUO, Rene MOLINA, Gabriel CASTILLE
  • Patent number: 11274141
    Abstract: A recombinant fusion protein is disclosed. The fusion protein comprises: (a) a CD55 peptide sequence, (b) a linker sequence C-terminal to the CD55 sequence, (c) a transmembrane domain C-terminal to the linker sequence, and (d) an intracellular domain C-terminal to the transmembrane domain. The fusion protein does not contain a GPI anchor. The fusion protein can be expressed with an N-terminal secretory signal peptide, which is cleaved to yield the mature protein on the surface of a cell line or an enveloped virus. An oncolytic virus expressing the fusion protein is resistant to complement inactivation and can be used to treat cancer.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 15, 2022
    Assignee: Wellstat ImmunoTherapeutics, LLC
    Inventors: Tianci Luo, Rene Molina, Gabriel Castille
  • Publication number: 20220062640
    Abstract: Devices, systems, and techniques for identifying electrodes closest to a target region of tissue are described. In one example, a device includes sensing circuitry configured to sense electrical signals from a plurality of electrode combinations. Processing circuitry identifies a first electrode combination of a first subset of electrode combinations. Each electrode combination of the first subset of electrode combination includes electrodes located at different axial positions along a length of the medical lead. The processing circuitry identifies a second electrode combination of a second subset of electrode combinations. Each electrode combination of the second subset of electrode combinations includes electrodes located at a same axial position and different circumferential positions around a perimeter of the medical lead. The processing circuitry then determines a third electrode combination and controls delivery of electrical stimulation via the third electrode combination.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 3, 2022
    Inventors: Robert S. Raike, Jadin C. Jackson, Scott R. Stanslaski, Eric J. Panken, Christopher L. Pulliam, Timothy R. Abraham, Michelle A. Case, Paula Andrea Elma Dassbach Green, Abbey Beuning Holt Becker, Rene A. Molina
  • Patent number: 11260231
    Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device determines a first set of stimulation parameters that define entrainment stimulation pulses configured to entrain electrical activity in a patient. The medical device may control a stimulation generator to generate the entrainment stimulation pulses according to the first set of stimulation parameters. The medical device may further determine a second set of stimulation parameters that define at least one desynchronization stimulation pulse configured to disrupt at least a portion of the electrical activity entrained by the entrainment stimulation pulses. The medical device may subsequently control the stimulation generator to generate the desynchronization stimulation pulse(s) according to the second set of stimulation parameters.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 1, 2022
    Assignee: Medtronic, Inc.
    Inventors: Rene A. Molina, Robert S. Raike, Scott R. Stanslaski
  • Publication number: 20220032063
    Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 3, 2022
    Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L. Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker