Patents by Inventor Rene de Waal Malefyt

Rene de Waal Malefyt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for modulating antigen-specific immune responses
    Patent number: 6884410
    Abstract: Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: April 26, 2005
    Assignee: Schering Corporation
    Inventors: Maria-Grazia Roncarolo, Rene de Waal Malefyt, Rosa Bacchetta, Herve M. Groux, Jan E. de Vries
  • Lymphocytes; methods
    Publication number: 20050048054
    Abstract: Provided are methods of modulating activity of regulatory T cells, CD4+ T cells, and CD8+ T cells. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: July 8, 2004
    Publication date: March 3, 2005
    Inventors: Shino Hanabuchi, Rene De Waal Malefyt, Yong-Jun Liu
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20050014199
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: August 25, 2004
    Publication date: January 20, 2005
    Applicant: Schering Corporation
    Inventors: Pedro Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Bazan, Robert Kastelein
  • Mammalian cytokine; related reagents
    Publication number: 20050009106
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: August 10, 2004
    Publication date: January 13, 2005
    Inventors: Rene de Waal Malefyt, Helmut Fickenscher, Bernhard Fleckenstein, Andrea Knappe
  • Uses of mammalian cytokine; related reagents
    Publication number: 20040219096
    Abstract: Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 4, 2004
    Inventors: Rene De Waal Malefyt, Marilyn Travis, Elena Vaisberg
  • Mammalian cytokines; related reagents
    Publication number: 20040198955
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 11, 2004
    Publication date: October 7, 2004
    Applicant: Schering Corporation, a New Jersey. corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • AK155 antibodies and binding fragments thereof
    Patent number: 6797813
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using these reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: September 28, 2004
    Assignee: Schering Corporation
    Inventors: Rene de Waal Malefyt, Helmut Flickensher, Bernhard Fleckenstein, Andrea Knappe
  • Regulatory T cells; methods
    Patent number: 6746670
    Abstract: Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: June 8, 2004
    Assignee: Schering Corporation
    Inventors: Megan K. Levings, Rene de Waal Malefyt, Maria Grazia Roncarolo
  • Mammalian cytokines; related reagents and methods
    Publication number: 20040091970
    Abstract: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: May 13, 2004
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: J. Fernando Bazan, Rene de Waal Malefyt, Yong-Jun Liu, Vassili Soumelis
  • Regulatory T cells; methods
    Publication number: 20040087018
    Abstract: Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.
    Type: Application
    Filed: October 14, 2003
    Publication date: May 6, 2004
    Inventors: Franck J. Barrat, Pieter Andre Boonstra, Huub Savelkoul, Rene de Waal Malefyt, Anne O'Garra
  • Regulatory T cells; methods
    Patent number: 6670146
    Abstract: Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: December 30, 2003
    Assignee: Schering Corporation
    Inventors: Franck J. Barrat, Pieter Andre Boonstra, Huub Savelkoul, Rene de Waal Malefyt, Anne O'Garra
  • Uses of mammalian cytokine; related reagents
    Publication number: 20030186875
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: January 30, 2003
    Publication date: October 2, 2003
    Inventors: Rene De Waal Malefyt, Liu Yong-Jun, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • Mammalian cytokines; related reagents and methods
    Publication number: 20030162261
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 27, 2003
    Publication date: August 28, 2003
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
  • Biological activity of AK155
    Publication number: 20030108958
    Abstract: This invention relates to cells that express a recombinant AK155 receptor, methods for screening for agent that modulates the effects of an AK155 on an AK155 receptor, and for methods of treating disease using agents that modulate the interactions between an AK155 and an AK155 receptor.
    Type: Application
    Filed: June 27, 2002
    Publication date: June 12, 2003
    Inventors: Rene de Waal Malefyt, Marehalli L. Nagalakshmi, Kevin Moore, Helmut Fickenscher
  • Mammalian cytokines; related reagents and methods
    Publication number: 20030099947
    Abstract: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: September 25, 2001
    Publication date: May 29, 2003
    Inventors: J. Fernando Bazan, Rene de Waal Malefyt, Yong-Jun Liu, Vassili Soumelis
  • Uses of mammalian cytokine; related reagents
    Publication number: 20030082184
    Abstract: Provided are methods of treatment for bone disorders related to bone deposition and resorption dysfunction. These bone disorders may be the result of inflammation, cancers, etc. Provided are methods of using agonists or antagonists of a cytokine molecule.
    Type: Application
    Filed: August 6, 2002
    Publication date: May 1, 2003
    Inventors: J. Fernando Bazan, Amy M. Beebe, Rene de Waal Malefyt, Daniel M. Gorman, Peter Kirk, Hirokazu Kurata, Donna Rennick
  • Mammalian cytokine; related reagents
    Publication number: 20030073199
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 28, 2002
    Publication date: April 17, 2003
    Inventors: Rene de Waal Malefyt, Helmut Flickensher, Bernhard Fleckenstein, Andrea Knappe
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20020173623
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: November 8, 2001
    Publication date: November 21, 2002
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; related reagents
    Publication number: 20020164609
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: November 30, 2001
    Publication date: November 7, 2002
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Regulatory T cells; methods
    Publication number: 20020090357
    Abstract: Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.
    Type: Application
    Filed: October 3, 2001
    Publication date: July 11, 2002
    Inventors: Franck J. Barrat, Pieter Andre Boonstra, Huub Savelkoul, Rene de Waal Malefyt, Anne O'Garra