Patents by Inventor Rene G. Ott

Rene G. Ott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FC mutants
    Patent number: 9657101
    Abstract: The present invention provides reagents, methods and systems for predicting the inhibitory activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is less than one (1).
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: May 23, 2017
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Rene G. Ott
  • FC MUTANTS
    Publication number: 20140093959
    Abstract: The present invention provides reagents, methods and systems for predicting the inhibitory activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is less than one (1).
    Type: Application
    Filed: December 3, 2013
    Publication date: April 3, 2014
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Rene G. Ott
  • Fc mutants
    Patent number: 8618251
    Abstract: The present invention provides reagents, methods and systems for predicting the inhibitory activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is less than one (1).
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: December 31, 2013
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Rene G. Ott