Patents by Inventor Rene Trussardi

Rene Trussardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120130121
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 24, 2012
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • Publication number: 20120041205
    Abstract: The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.
    Type: Application
    Filed: October 21, 2011
    Publication date: February 16, 2012
    Inventors: Christophe Pfleger, Paul Spurr, Rene Trussardi, Pius Waldmeier, Shaoning Wang
  • Publication number: 20090306423
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof. 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Application
    Filed: May 29, 2009
    Publication date: December 10, 2009
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • Publication number: 20090176886
    Abstract: The present invention relates to polymorphic forms of (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester phosphate, which is a potent inhibitor of viral neuraminidase.
    Type: Application
    Filed: December 19, 2008
    Publication date: July 9, 2009
    Inventors: Andre Bubendorf, Pierre Goldbach, Olaf Grassmann, Michael Henning, Ines Sauer, Rene Trussardi
  • Publication number: 20090143589
    Abstract: The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.
    Type: Application
    Filed: November 26, 2008
    Publication date: June 4, 2009
    Inventors: Christophe Pfleger, Paul Spurr, Rene Trussardi, Pius Waldmeier, Shaoning Wang
  • Patent number: 7531687
    Abstract: The invention provides a new process for the conversion of shikimic acid to oseltamivir (I), and optionally to an acid addition salt, via the intermediate phosphoramide VII.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: May 12, 2009
    Assignee: Roche Palo Alto LLC
    Inventor: René Trussardi
  • Patent number: 7514580
    Abstract: The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula and pharmaceutically acceptable addition salts thereof wherein R1, R1? are independent of each other H or alkyl, R2 is an alkyl and R3, R4 are independent of each other H or an alkanoyl, with the proviso that not both R3 and R4 are H. 4,5-diamino shikimic acid derivatives of formula I, especially the (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester and its pharmaceutically acceptable additional salts are potent inhibitors of viral neuraminidase.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: April 7, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Karpf, Rene Trussardi
  • Publication number: 20090076296
    Abstract: The invention provides a new process for the conversion of shikimic acid to oseltamivir (I), and optionally to an acid addition salt, via the intermediate phosphoramide VII.
    Type: Application
    Filed: September 18, 2008
    Publication date: March 19, 2009
    Inventor: Rene Trussardi
  • Patent number: 7335687
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: February 26, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Publication number: 20080003652
    Abstract: The present invention relates to a process for making a compound of formula (I) The process involves the use of an enzyme. Compounds of formula (I) are intermediates in the manufacture of Dolastatin 10 analogues, which are useful in the treatment of cancer.
    Type: Application
    Filed: June 14, 2007
    Publication date: January 3, 2008
    Inventors: Hans Iding, Rudolf Schmid, Rene Trussardi
  • Publication number: 20060155110
    Abstract: The present invention relates to the manufacture of the compounds of formula (I) said compounds of formula (I), or their lithium salts, are valuable intermediates in the manufacture of Dolastatin 10 analogues, which are useful in the treatment of cancer.
    Type: Application
    Filed: January 11, 2006
    Publication date: July 13, 2006
    Inventors: Rudolf Schmid, Rene Trussardi
  • Publication number: 20060128970
    Abstract: The present invention relates to the manufacture of the compounds of formula (I) said compounds of formula (I) being valuable intermediates in the manufacture of Dolastatin 10 analogues, which are useful in the treatment of cancer.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 15, 2006
    Inventors: Fritz Bliss, Michel Lalonde, Rudolf Schmid, Rene Trussardi
  • Publication number: 20060047002
    Abstract: The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula and pharmaceutically acceptable addition salts thereof wherein R1, R1? are independent of each other H or alkyl, R2 is an alkyl and R3, R4 are independent of each other H or an alkanoyl, with the proviso that not both R3 and R4 are H. 4,5-diamino shikimic acid derivatives of formula I, especially the (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester and its pharmaceutically acceptable additional salts are potent inhibitors of viral neuraminidase.
    Type: Application
    Filed: August 30, 2005
    Publication date: March 2, 2006
    Inventors: Martin Karpf, Rene Trussardi
  • Patent number: 6939986
    Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: September 6, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Karpf, René Trussardi
  • Publication number: 20050176766
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: December 15, 2004
    Publication date: August 11, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Patent number: 6858651
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: February 22, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Patent number: 6562977
    Abstract: The present invention is concerned with mixed anhydrides. The mixed anhydrides are prepared by adding an adjuvant base to a mixture of acid and reactive acid derivative. The mixed anhydrides play an role primarily in activating and coupling reactions.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: May 13, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Karpf, René Trussardi
  • Patent number: 6489479
    Abstract: The present invention is concerned with an improved process for the manufacture of mixed anhydrides. The process comprises adding an adjuvant base to a mixture of acid and reactive acid derivative. It is especially suitable for use in the synthesis of peptides and/or for the manufacture of pharmaceutically active substances or corresponding intermediates.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: December 3, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Martin Karpf, René Trussardi
  • Patent number: 6437171
    Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds of formula wherein R1, R1′, R2, R2′, R3 and R4 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein R1, R′, R2 and R2′ have the meaning given in the specification.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: August 20, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Martin Karpf, René Trussardi
  • Publication number: 20020095040
    Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.
    Type: Application
    Filed: February 22, 2002
    Publication date: July 18, 2002
    Inventors: Martin Karpf, Rene Trussardi