Patents by Inventor Renzo Rossi

Renzo Rossi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of paroxetine
    Patent number: 6583287
    Abstract: A process for the production of paroxetine is described, wherein N-substituted derivatives of 4-(p-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine are treated according to the following sequence of reactions: (a) hydrogenation catalyzed by transition metal complexes with chiral diphosphinic ligands; (b) —OH derivatisation and nucleophilic substitution, the substituent being sesamol; (c) N-dealkylation. The process is highly stereospecific and brings about the formation of intermediates enriched with the desired isomeric components, which are converted into paroxetine in quantitative yields.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 24, 2003
    Assignee: Recordati S.A. Chemical and Pharmaceutical Company
    Inventors: Renzo Rossi, Stefano Turchetta, Maria Donnarumma
  • Process for the preparation of terbinafine
    Patent number: 6515181
    Abstract: A process for the preparation of terbinafine which comprises the reaction of tert-butylacetylene with a compound of formula (II) characterized in that the reaction is carried out in the presence of copper (I) salts and of a base, in the absence of palladium.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: February 4, 2003
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Renzo Rossi
  • Process for the preparation of terbinafine
    Publication number: 20020123651
    Abstract: A process for the preparation of terbinafine which comprises the reaction of tert-butylacetylene with a compound of formula (II) 1
    Type: Application
    Filed: February 28, 2002
    Publication date: September 5, 2002
    Inventors: Graziano Castaldi, Giuseppe Barreca, Renzo Rossi
  • Process for the preparation of 2-(4-methylphenyl)-benzoic acid derivatives
    Patent number: 6433214
    Abstract: A process for the preparation of 2-(4-methylphenyl)benzoic acid C1-6alkyl esters by reaction of a sulfonic derivative of formula wherein R is C1-6alkyl and R1 is optionally perfluorinated C1-6alkyl or optionally substituted C1-6aryl, with a 4-methylphenylzinc halide.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: August 13, 2002
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Antonio Tarquini, Renzo Rossi