Patents by Inventor Reto Stocklin
Reto Stocklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10149812Abstract: A cosmetic composition containing as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide is provided. In particular, a composition wherein the mu-conotoxin peptide is Arginine, lysine polypeptide (INCI name: pyroglutamyl s-mu-conotoxin CnIIIc amide acetate), CAS Number: 937286-43-6 (renumbered 936616-33-0), Molecular formula C92,H139,N35,O28,S6 acetate salt (molar mass 2376 g/mol.) is provided. The composition can be used to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin.Type: GrantFiled: December 27, 2016Date of Patent: December 11, 2018Assignee: ACTIVENInventors: Reto Stocklin, Jean-Marc Le Doussal, Louis Lamy, Bethsabee Coutaz
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Publication number: 20180148483Abstract: The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.Type: ApplicationFiled: February 21, 2017Publication date: May 31, 2018Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Philippe FAVREAU, Evelyne BENOIT, Jordi MOLGO, Reto STOCKLIN
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Publication number: 20170226166Abstract: The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and /or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.Type: ApplicationFiled: February 21, 2017Publication date: August 10, 2017Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.), ACTIVENInventors: Philippe FAVREAU, Evelyne BENOIT, Jordi MOLGO, Reto STOCKLIN
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Publication number: 20170157016Abstract: A cosmetic composition containing as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide is provided. In particular, a composition wherein the mu-conotoxin peptide is Arginine, lysine polypeptide (INCI name: pyroglutamyl s-mu-conotoxin CnIIIc amide acetate), CAS Number: 937286-43-6 (renumbered 936616-33-0), Molecular formula C92,H139,N35,O28,S6 acetate salt (molar mass 2376 g/mol.) is provided. The composition can be used to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin.Type: ApplicationFiled: December 27, 2016Publication date: June 8, 2017Inventors: Reto STOCKLIN, Jean-Marc LE DOUSSAL, Louis LAMY, Bethsabee COUTAZ
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Patent number: 9644011Abstract: The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.Type: GrantFiled: January 11, 2013Date of Patent: May 9, 2017Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Philippe Favreau, Evelyne Benoit, Jordi Molgo, Reto Stöcklin
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Patent number: 9566227Abstract: A cosmetic composition including as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide It further concerns a composition wherein the mu-conotoxin peptide is Argninine, lysine polypeptide, CAS Number: 937286-43-6, Molecular formula C92,H139,N35,O28,S6 acetate salt (molar mass 2376 g/mol.). Also, the use of the composition to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin.Type: GrantFiled: April 15, 2013Date of Patent: February 14, 2017Assignee: ACTIVENInventors: Reto Stocklin, Jean-Marc Le Doussal, Louis Lamy, Bethsabee Coutaz
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Publication number: 20150132235Abstract: A cosmetic composition including as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide It further concerns a composition wherein the mu-conotoxin peptide is Argninine, lysine polypeptide, CAS Number: 937286-43-6, Molecular formula C92, H139, N35, O28, S6 acetate salt (molar mass 2376 g/mol.). Also, the use of the composition to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin.Type: ApplicationFiled: April 15, 2013Publication date: May 14, 2015Applicant: ACTIVENInventors: Reto Stocklin, Jean-Marc Le Doussal, Louis Lamy, Bethsabee Coutaz
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Publication number: 20130203676Abstract: The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.Type: ApplicationFiled: January 11, 2013Publication date: August 8, 2013Inventors: Philippe Favreau, Evelyne Benoit, Jordi Molgo, Reto Stöcklin
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Publication number: 20120087969Abstract: In one embodiment, the present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. An embodiment of the invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.Type: ApplicationFiled: November 8, 2006Publication date: April 12, 2012Applicants: Centre National de la Recherche Scientifique (C.N.R.S.), Atheris LaboratoriesInventors: Philippe Favreau, Evelyne Benoit, Jordi Molgo, Reto Stöcklin
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Patent number: 7943340Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel dipetidyl peptidase IV (DPPIV) polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The aminopeptidase polypeptides, referred to herein as DPPIV proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: GrantFiled: July 3, 2008Date of Patent: May 17, 2011Assignee: Funzyme Biotechnologies SAInventors: Michel Monod, Reto Stocklin, Eric Grouzmann
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Patent number: 7541157Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.Type: GrantFiled: May 28, 2003Date of Patent: June 2, 2009Assignee: Commissariat a l'Energie AtomiqueInventors: Vincent Dive, André Menez, Reto Stocklin, Bertrand Tavitian, Fabrice Beau, Bertrand Czarny, Joël Cotton
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Publication number: 20090130737Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein as EXOX nucleic acids and proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: ApplicationFiled: July 3, 2008Publication date: May 21, 2009Applicant: Funzyme Biotechnologies SAInventors: Michel Monod, Reto Stocklin, Eric Grouzmann
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Patent number: 7468267Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein as EXOX nucleic acids and proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: GrantFiled: August 25, 2004Date of Patent: December 23, 2008Assignee: Funzyme Biotechnologies SAInventors: Michel Monod, Reto Stocklin, Eric Grouzmann
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Patent number: 7354734Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein as EXOX nucleic acids and proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: GrantFiled: August 25, 2004Date of Patent: April 8, 2008Assignee: Funzyme Biotechnologies SAInventors: Michel Monod, Reto Stocklin, Eric Grouzmann
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Publication number: 20070009988Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein as EXOX nucleic acids and proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: ApplicationFiled: August 25, 2004Publication date: January 11, 2007Applicant: FUNZYME BIOTECHNOLOGIES SAInventors: Michel Monod, Reto Stocklin, Eric Grouzmann
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Publication number: 20060228296Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, the products from the molecule groups obtained and the application thereof in order to identify molecules that are capable of binding selectively to a tissue or a particular organ. The inventive method can be used for the development of novel therapeutic compounds and contrast agents for medical imaging and for the screening of medicaments.Type: ApplicationFiled: May 28, 2003Publication date: October 12, 2006Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Vincent Dive, Andre Menez, Reto Stocklin, Bertrand Tavitian, Fabrice Beau, Bertrand Czarny, Joel Cotton
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Publication number: 20050158298Abstract: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein as EXOX nucleic acids and proteins of the invention are useful in a variety of medical, research, and commercial applications.Type: ApplicationFiled: August 25, 2004Publication date: July 21, 2005Inventors: Michel Monod, Reto Stocklin, Eric Grouzmann