Patents by Inventor Rey-Ting Guo

Rey-Ting Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cutinase having improved enzymatic activity
    Patent number: 11939603
    Abstract: A modified cutinase is disclosed. The cutinase has the modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of asparagine at position 181 with alanine, or substitutions of asparagine at position 181 with alanine and phenylalanine at position 235 with leucine. The modified enzyme has improved PET-hydrolytic activity, and thus, the high-activity PET hydrolase is obtained, and the industrial application value of the PET hydrolase is enhanced.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: March 26, 2024
    Assignee: HUBEI UNIVERSITY
    Inventors: Chun-Chi Chen, Jian-Wen Huang, Jian Min, Xian Li, Beilei Shi, Panpan Shen, Yu Yang, Yumei Hu, Longhai Dai, Lilan Zhang, Yunyun Yang, Rey-Ting Guo
  • PET hydrolase having improved thermal stability
    Patent number: 11680252
    Abstract: A PET hydrolase having improved thermal stability is disclosed. The PET hydrolase has a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of asparagine at position 248 or a corresponding position with proline.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: June 20, 2023
    Assignee: HUBEI UNIVERSITY
    Inventors: Chun-Chi Chen, Jian-Wen Huang, Xiuqin Li, Wei Zeng, Lilan Zhang, Yunyun Yang, Longhai Dai, Jian Min, Yu Yang, Rey-Ting Guo
  • PET HYDROLASE HAVING IMPROVED THERMAL STABILITY
    Publication number: 20220307000
    Abstract: A PET hydrolase having improved thermal stability is disclosed. The PET hydrolase has a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of asparagine at position 248 or a corresponding position with proline.
    Type: Application
    Filed: November 22, 2021
    Publication date: September 29, 2022
    Inventors: Chun-Chi Chen, Jian-Wen Huang, Xiuqin Li, Wei Zeng, Lilan Zhang, Yunyun Yang, Longhai Dai, Jian Min, Yu Yang, Rey-Ting Guo
  • Cellulase having improved enzymatic activity
    Patent number: 10479985
    Abstract: A cellulase having improved enzymatic activity is disclosed. The cellulase has a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of methionine at position 120 or a corresponding position with asparagine.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: November 19, 2019
    Assignee: HUBEI UNIVERSITY
    Inventors: Chun-Chi Chen, Jian-Wen Huang, Longhai Dai, Xuejing Yu, Chin-Yu Chen, Shan Wu, Zhichun Zhan, Lilan Zhang, Chao Zhai, Lixin Ma, Rey-Ting Guo
  • Xylosidase having improved enzymatic activity
    Patent number: 10385346
    Abstract: A xylosidase having improved enzymatic activity is disclosed. The amino acid sequence of the xylosidase is a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of phenylalanine at position 35 with glutamate, and/or a substitution of glutamine at position 41 with histidine.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: August 20, 2019
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Ya-Shan Cheng, Tzu-Hui Wu, Cheng-Yen Lin, Hui-Lin Lai, Cheng-Bin Zheng, Ting-Yung Huang, I-Hsuan Lin, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo
  • Lysozyme having improved enzymatic activity
    Patent number: 10323237
    Abstract: A lysozyme having improved enzymatic activity is disclosed. The amino acid sequence of the lysozyme is a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of histidine at position 166 or a corresponding position with lysine.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: June 18, 2019
    Assignee: CHENGDU BEACON BIO-TECHNOLOGY CO., LTD.
    Inventors: Chun-Chi Chen, Tao Wang, Jian-Wen Huang, Rey-Ting Guo
  • Lactone hydrolase and method of degrading alpha-zearalenol using the same
    Patent number: 10316303
    Abstract: A lactone hydrolase having improved activity towards ?-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of SEQ ID NO: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading ?-zearalenol using such lactone hydrolase is also disclosed.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: June 11, 2019
    Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Rey-Ting Guo, Yingying Zheng, Zhongxia Xu, Chun-Chi Chen, Wei Peng, Weidong Liu, Je-Ruei Liu, Yanhe Ma
  • LYSOZYME HAVING IMPROVED ENZYMATIC ACTIVITY
    Publication number: 20190127716
    Abstract: A lysozyme having improved enzymatic activity is disclosed. The amino acid sequence of the lysozyme is a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of histidine at position 166 or a corresponding position with lysine.
    Type: Application
    Filed: August 21, 2018
    Publication date: May 2, 2019
    Inventors: Chun-Chi Chen, Tao Wang, Jian-Wen Huang, Rey-Ting Guo
  • XYLOSIDASE HAVING IMPROVED ENZYMATIC ACTIVITY
    Publication number: 20190119687
    Abstract: A xylosidase having improved enzymatic activity is disclosed. The amino acid sequence of the xylosidase is a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of phenylalanine at position 35 with glutamate, and/or a substitution of glutamine at position 41 with histidine.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 25, 2019
    Inventors: Ya-Shan Cheng, Tzu-Hui Wu, Cheng-Yen Lin, Hui-Lin Lai, Cheng-Bin Zheng, Ting-Yung Huang, I-Hsuan Lin, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo
  • Glucose oxidase having improved thermostability
    Patent number: 10233430
    Abstract: A glucose oxidase having improved thermostability is disclosed. The amino acid sequence of the glucose oxidase is a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of glutamate at position 129 with proline, and/or a substitution of glutamine at position 243 with valine.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: March 19, 2019
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO.,LTD.
    Inventors: Ya-Shan Cheng, Tzu-Hui Wu, Cheng-Yen Lin, Hui-Lin Lai, Cheng-Bin Zheng, Ting-Yung Huang, I-Hsuan Lin, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo
  • Phytase having improved thermostability
    Patent number: 10011822
    Abstract: A phytase having improved thermostability is disclosed. The phytase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is one of mutations A to D. The mutation A is to substitute amino acids at positions 143 and 262 with cysteine, the mutation B is to substitute amino acids at positions 259 and 312 with cysteine, the mutation C is to substitute amino acids at positions 205 and 257 with cysteine, and the mutation D is to substitute amino acids at positions 264 and 309 with cysteine.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: July 3, 2018
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Tzu-Hui Wu, Ya-Shan Cheng, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo
  • Cellulase having improved thermostability
    Patent number: 9944915
    Abstract: A cellulase having improved thermostability is disclosed. The cellulase comprises a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is adding a cysteine in N terminal and adding a glycine and a cysteine or adding a proline and a cysteine in C terminal.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: April 17, 2018
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Rey-Ting Guo, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • Cellulase having improved enzymatic activity
    Patent number: 9809807
    Abstract: A cellulase having improved enzymatic activity is disclosed. The cellulase comprises a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Tyrosine at position 161 with Histidine.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: November 7, 2017
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Rey-Ting Guo, Chun-Chi Chen, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • PHYTASE HAVING IMPROVED THERMOSTABILITY
    Publication number: 20170240872
    Abstract: A phytase having improved thermostability is disclosed. The phytase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is one of mutations A to D. The mutation A is to substitute amino acids at positions 143 and 262 with cysteine, the mutation B is to substitute amino acids at positions 259 and 312 with cysteine, the mutation C is to substitute amino acids at positions 205 and 257 with cysteine, and the mutation D is to substitute amino acids at positions 264 and 309 with cysteine.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 24, 2017
    Inventors: Rey-Ting Guo, Chun-Chi Chen, Ya-Shan Cheng, Tzu-Hui Wu, Jian-Wen Huang, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • LACTONE HYDROLASE AND METHOD OF DEGRADING ALPHA-ZEARALENOL USING THE SAME
    Publication number: 20170191046
    Abstract: A lactone hydrolase having improved activity towards ?-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of SEQ ID NO: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading ?-zearalenol using such lactone hydrolase is also disclosed.
    Type: Application
    Filed: December 1, 2016
    Publication date: July 6, 2017
    Inventors: Rey-Ting Guo, Yingying Zheng, Zhongxia Xu, Chun-Chi Chen, Wei Peng, Weidong Liu, Je-Ruei Liu, Yanhe Ma
  • CELLULASE HAVING IMPROVED THERMOSTABILITY
    Publication number: 20170183641
    Abstract: A cellulase having improved thermostability is disclosed. The cellulase comprises a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is adding a cysteine in N terminal and adding a glycine and a cysteine or adding a proline and a cysteine in C terminal.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 29, 2017
    Inventors: Rey-Ting Guo, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • Thermostable pectinase
    Patent number: 9650625
    Abstract: A pectinase having improved thermostability is disclosed. The pectinase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of serine at position 181 with phenylalanine, methionine or leucine.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: May 16, 2017
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Rey-Ting Guo, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • THERMOSTABLE PECTINASE
    Publication number: 20170121699
    Abstract: A pectinase having improved thermostability is disclosed. The pectinase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of serine at position 181 with phenylalanine, methionine or leucine.
    Type: Application
    Filed: October 26, 2016
    Publication date: May 4, 2017
    Inventors: Rey-Ting Guo, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • Phytase having improved enzymatic activity
    Patent number: 9194010
    Abstract: A phytase having improved enzymatic activity is disclosed. The phytase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Valine at position 90 with Threonine. Alternatively, the phytase has a modified amino acid sequence of SEQ ID NO: 6, wherein the modification is a substitution of Asparagine at position 204 with Alanine or a substitution of Serine at position 206 with Alanine.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: November 24, 2015
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Rey-Ting Guo, Tzu-Hui Wu, Ya-Shan Cheng, Jian-Wen Huang, Hui-Lin Lai, Cheng-Yen Lin, Ting-Yung Huang
  • ?-mannanase having improved production yields and enzymatic activity
    Patent number: 8999695
    Abstract: A ?-mannanase having increased production yield and enzymatic activity is disclosed. The ?-mannanase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Tyrosine at position 25 with Histidine.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: April 7, 2015
    Assignee: DongGuan APAC Biotechnology Co., Ltd.
    Inventors: Rey-Ting Guo, Jian-Wen Huang, Ya-Shan Cheng, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Ting-Yung Huang