Patents by Inventor Rhonda R. Voskuhl

Rhonda R. Voskuhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Estrogen therapy for brain gray matter atrophy and associated disability
    Patent number: 11865122
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: January 9, 2024
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Estrogen receptor ligand treatment for neurodegenerative diseases
    Patent number: 11628146
    Abstract: The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ER?) ligand.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: April 18, 2023
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Estrogen receptor ligands, compositions and methods related thereto
    Patent number: 11622954
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: April 11, 2023
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • ESTROGEN THERAPY FOR BRAIN GRAY MATTER ATROPHY AND ASSOCIATED DISABILITY
    Publication number: 20210213033
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Application
    Filed: October 28, 2020
    Publication date: July 15, 2021
    Inventor: Rhonda R. Voskuhl
  • ESTROGEN RECEPTOR LIGANDS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20210196667
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Application
    Filed: March 16, 2021
    Publication date: July 1, 2021
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • ESTROGEN COMBINATION FOR TREATMENT OF MULTIPLE SCLEROSIS
    Publication number: 20210137943
    Abstract: Provided are methods for treating multiple sclerosis using a continuous regimen of estrogen in combination with periodic administration of a progestrogen.
    Type: Application
    Filed: October 2, 2020
    Publication date: May 13, 2021
    Inventor: Rhonda R. Voskuhl
  • Estrogen receptor ligands, compositions and methods related thereto
    Patent number: 10980767
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: April 20, 2021
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • ESTROGEN RECEPTOR LIGAND TREATMENT FOR NEURODEGENERATIVE DISEASES
    Publication number: 20210008002
    Abstract: The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ER?) ligand.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 14, 2021
    Inventor: Rhonda R. Voskuhl
  • Estrogen therapy for brain gray matter atrophy and associated disability
    Patent number: 10821117
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: November 3, 2020
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Estrogen combination for treatment of multiple sclerosis
    Patent number: 10799512
    Abstract: Provided are methods for treating multiple sclerosis using a continuous regimen of estrogen in combination with periodic administration of a progestogen.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 13, 2020
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Estrogen receptor ligand treatment for neurodegenerative diseases
    Patent number: 10758496
    Abstract: The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ER?) ligand.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Diarylpropionitrile therapy for treatment of multiple sclerosis
    Patent number: 10610535
    Abstract: The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these Th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post-partum period.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: April 7, 2020
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Methods of monitoring estriol therapy
    Patent number: 10406169
    Abstract: Provided are methods for treating a neurodegenerative disease, such as multiple sclerosis, in a subject receiving a first estriol treatment regimen, comprising obtaining a measurement of the serum estriol concentration in the blood of the subject, and administering a second estriol treatment regimen to the subject if the serum estriol concentration is less than 6 ng/mL. The daily amount of estriol administered during the second estriol treatment regimen is preferably greater than the daily amount of estriol administered during the first estriol treatment regimen.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: September 10, 2019
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Pharmaceutical packaging for estriol therapy
    Patent number: 10369158
    Abstract: This invention relates to novel packaged pharmaceutical products for the treatment of neurodegenerative diseases, such as multiple sclerosis, and methods of using these products.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 6, 2019
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • ESTROGEN RECEPTOR LIGANDS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20190192476
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Application
    Filed: September 8, 2017
    Publication date: June 27, 2019
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • ESTRIOL THERAPY FOR TREATMENT OF MULTIPLE SCLEROSIS
    Publication number: 20180161346
    Abstract: The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these Th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post-partum period.
    Type: Application
    Filed: August 24, 2017
    Publication date: June 14, 2018
    Inventor: Rhonda R. Voskuhl
  • Compositions and methods for maintaining cognitive function
    Patent number: 9962395
    Abstract: Provided are methods for reducing the progression of cognitive decline in a post-menopausal woman using a continuous regimen of estrogen in combination with periodic administration of a progestogen.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: May 8, 2018
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • METHODS OF MONITORING ESTRIOL THERAPY
    Publication number: 20180085379
    Abstract: Provided are methods for treating a neurodegenerative disease, such as multiple sclerosis, in a subject receiving a first estriol treatment regimen, comprising obtaining a measurement of the serum estriol concentration in the blood of the subject, and administering a second estriol treatment regimen to the subject if the serum estriol concentration is less than 6 ng/mL. The daily amount of estriol administered during the second estriol treatment regimen is preferably greater than the daily amount of estriol administered during the first estriol treatment regimen.
    Type: Application
    Filed: March 29, 2016
    Publication date: March 29, 2018
    Applicant: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • ESTROGEN RECEPTOR LIGAND TREATMENT FOR NEURODEGENERATIVE DISEASES
    Publication number: 20170304216
    Abstract: The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ER?) ligand.
    Type: Application
    Filed: September 1, 2015
    Publication date: October 26, 2017
    Inventor: Rhonda R. Voskuhl
  • ESTROGEN THERAPY FOR BRAIN GRAY MATTER ATROPHY AND ASSOCIATED DISABILITY
    Publication number: 20170290845
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Application
    Filed: September 1, 2015
    Publication date: October 12, 2017
    Applicant: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl