Patents by Inventor Ricardo Orprecio

Ricardo Orprecio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10301274
    Abstract: Disclosed are salts of a compound of formula 1, as shown below, where R1, R2, R3, R4? R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of the salts of the compounds of formula 1, and intermediates used therein. The salts of the compound of formula 1 can be useful for preparation of halichondrin analogs such as eribulin.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: May 28, 2019
    Assignee: Sandoz AG
    Inventors: Fabio E. s. Souza, Ricardo Orprecio, Ming Pan
  • Patent number: 9695187
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 4, 2017
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • Patent number: 9650397
    Abstract: Discloses is a process for preparation of a compound of formula 11, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 11 can be useful in the preparation of halinchondrin analogs.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 16, 2017
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E.s. Souza, Jason A. Bexrud, Ricardo Orprecio, Boris Gorin
  • Publication number: 20170066735
    Abstract: Disclosed are salts of a compound of formula 1, as shown below, where R1, R2, R3, R4? R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of the salts of the compounds of formula 1, and intermediates used therein. The salts of the compound of formula 1 can be useful for preparation of halichondrin analogs such as eribulin.
    Type: Application
    Filed: March 6, 2015
    Publication date: March 9, 2017
    Applicant: Alphora Research Inc.
    Inventors: Fabio E.s. Souza, Ricardo Orprecio, Ming Pan
  • Patent number: 9416140
    Abstract: Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: August 16, 2016
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Jason A. Bexrud, Ricardo Orprecio, Boris Gorin
  • Publication number: 20160152631
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10 , R11 , R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: Fabio E.S. SOUZA, Alena RUDOLPH, Ming PAN, Boris GORIN, Teng Ko NGOOI, Jason A. BEXRUD, Ricardo ORPRECIO, Huzaifa RANGWALA
  • Publication number: 20160090391
    Abstract: Discloses is a process for preparation of a compound of formula 11, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 11 can be useful in the preparation of halinchondrin analogs.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 31, 2016
    Inventors: Fabio E.s. Souza, Jason A. Bexrud, Ricardo Orprecio, Boris Gorin
  • Patent number: 9278979
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: March 8, 2016
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • Publication number: 20160031900
    Abstract: Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Inventors: Fabio E.S. SOUZA, Jason A. BEXRUD, Ricardo ORPRECIO, Boris GORIN
  • Patent number: 9174956
    Abstract: Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: November 3, 2015
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Jason A. Bexrud, Ricardo Orprecio, Boris Gorin
  • Publication number: 20150073157
    Abstract: Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin.
    Type: Application
    Filed: December 14, 2012
    Publication date: March 12, 2015
    Applicant: ALPHORA RESEARCH INC.
    Inventors: Fabio E.S. Souza, Jason A. Bexrud, Ricardo Orprecio, Boris Gorin
  • Publication number: 20150065733
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Fabio E.S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • Patent number: 7321047
    Abstract: An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N?C?X??(I) where R represents an aromatic ring optionally substituted with one or more electron withdrawing groups, n=0 or 1 and X is oxygen or sulphur; so as to produce a crystallizable THC carbamate of formula II: wherein X and R are as defined above, R? is a C3-C10 alkyl group and the dotted lines indicate optional unsaturation including aromatic, separating the compound of formula II from solution in isolation of other THC derivatives, and hydrolyzing the compound of formula II to form the individual tetrahydrocannabinol isomer of interest.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: January 22, 2008
    Assignee: Alphora Research Inc.
    Inventors: Jason Edward Field, Jan Oudenes, Boris Ivanovich Gorin, Ricardo Orprecio, Fabio Eduardo Silva e Souza, Navindra Jainarine Ramjit, Emma-Louise Moore
  • Publication number: 20060264647
    Abstract: An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N?C?X??(I) where R represents an aromatic ring optionally substituted with one or more electron withdrawing groups, n=0 or 1 and X is oxygen or sulphur; so as to produce a crystallizable THC carbamate of formula II: wherein X and R are as defined above, R? is a C3-C10 alkyl group and the dotted lines indicate optional unsaturation including aromatic, separating the compound of formula II from solution in isolation of other THC derivatives, and hydrolyzing the compound of formula II to form the individual tetrahydrocannabinol isomer of interest.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 23, 2006
    Inventors: Jason Field, Jan Oudenes, Boris Gorin, Ricardo Orprecio, Fabio Souza, Navindra Ramjit, Emma-Louise Moore