Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.

Abstract: A transistor is disclosed, comprising: a layer of semiconductor material comprising a first portion, a second portion, and a third portion connecting the first portion to the second portion and providing a semiconductive channel between the first portion and the second portion; a conductive first terminal covering and in electrical contact with said first portion of the layer of semiconductor material; a conductive second terminal covering and in electrical contact with said second portion of the layer of semiconductor material; a conductive gate terminal comprising a first overlapping portion covering at least part of the first terminal, and a channel portion covering the third portion of the layer of semiconductor material; and a layer of a first dielectric material, having a first dielectric constant, arranged between the first overlapping portion and the first terminal, and between the channel portion of the gate terminal and the third portion of the layer of semiconductor material.

Abstract: A process for bleaching trichome fibers individualized from a trichome source, such as a leaf and/or a stem, is disclosed. The process of bleaching degrades trichome associated protein. Further, the bleaching processes improves the color of the trichomes.

Abstract: A process for bleaching trichome fibers individualized from a trichome source, such as a leaf and/or a stem, is disclosed. The process of bleaching degrades trichome associated protein. Further, the bleaching processes improves the color of the trichomes.

Abstract: A crop scanning system for determining a parameter associated with a plurality of harvestable items of a crop, the harvestable items being beneath a ground surface, the crop scanning system including: a scanning head assembly including at least one scanning device configured to perform a scanning operation in relation to the harvestable items, the scanning device being configured to emit a ground penetrating radar signal or pulse and to generate scan data including a representation of the harvestable items; an imaging system configured to capture an image of a part of the crop which is above the ground surface and to generate image data including a representation of one or more stems associated with the harvestable items; and an analysis system configured to use the scan data and the image data to determine the parameter associated with the harvestable items, wherein the at least one parameter includes a predicted size of the harvestable items.

Abstract: The present disclosure relates to methods and systems for realization of a reference pressure as well as calibration of devices under test. The techniques leverage the measurement of buoyancy artifacts under vacuum and pressure conditions, and the use of gas law equations and related variables to obtain low uncertainty reference values for pressure among others. The techniques can include measuring an absolute mass difference of buoyancy artifacts under vacuum; measuring effective masses of the buoyancy artifacts under a gas pressure condition, and determining an effective mass difference between the buoyancy artifacts; and determining a low-uncertainty pressure based on the absolute mass difference, effective mass difference, Boltzmann constant, volume difference, molecular weight of the gas at pressure, and temperature of the measurements.

Abstract: Provided are methods of producing target capture nucleic acids. The methods comprise bidirectionally amplifying a circular nucleic acid template by rolling circle amplification (RCA) using first and second primers, where the circular nucleic acid template comprises a target nucleotide sequence and a restriction site. The bidirectional amplification produces a double-stranded concatemer comprising a first strand comprising a plurality of linked units, each unit comprising the target nucleotide sequence and the restriction site, and a second strand which is the reverse complement of the first strand. The methods further comprise digesting the double-stranded concatemer using a restriction endonuclease that cleaves the restriction site to produce a plurality of restriction fragments. Also provided are target capture nucleic acids produced according to such methods. Methods of capturing target nucleic acids using target capture nucleic acids produced according to such methods are also provided.

Abstract: Provided are methods of producing nucleic acid libraries. The methods include combining single-stranded nucleic acid binding protein-bound single-stranded nucleic acid (SSB-bound ssNA), an adapter oligonucleotide, and a splint oligonucleotide, to form complexes including the splint oligonucleotide hybridized to a terminal region of the SSB-bound ssNA and to the adapter oligonucleotide. An end of the first adapter oligonucleotide is adjacent to an end of the first terminal region of the SSB-bound ssNA, and the methods may further include covalently linking the adjacent ends. Also provided are compositions and kits that find use, e.g., in practicing the methods of the present disclosure.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: The present invention provides novels method of targeting delivery of a compound to hypoxic cells, for example treatment of diseases and disorders associated with hypoxia, comprising administration of a construct comprising a targeting carrier peptide and a compound for delivery to a hypoxic cell. The invention also provides novel methods for the treatment of diseases or disorders of the eye by administration of a novel construct, a nucleic acid encoding a novel construct, and/or a nucleic acid vector comprising a nucleic acid encoding a novel construct. The invention further provides novel constructs, nucleic acids encoding such constructs, and/or nucleic acid vectors comprising nucleic acids encoding such constructs.

Abstract: Provided are methods of producing nucleic acid libraries. The methods include combining single-stranded nucleic acid binding protein-bound single-stranded nucleic acid (SSB-bound ssNA), an adapter oligonucleotide, and a splint oligonucleotide, to form complexes including the splint oligonucleotide hybridized to a terminal region of the SSB-bound ssNA and to the adapter oligonucleotide. An end of the first adapter oligonucleotide is adjacent to an end of the first terminal region of the SSB-bound ssNA, and the methods may further include covalently linking the adjacent ends. Also provided are compositions and kits that find use, e.g., in practicing the methods of the present disclosure.

Abstract: An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.

Abstract: An apparatus for a safety-relevant application and a method for operating the apparatus. The apparatus has a user interface to display digits. The digits are intended to be filled with numerical values by a user. The user interface is designed to limit a selection of digits available for a user input when a numerical value is input by the user, for example the user's first input, for one of the digits that are to be filled.

Abstract: A clamp apparatus including band means which is annular or substantially annular in form. The band means has two opposing ends and protruding means are provided to protrude outwardly of the band means at each of the opposing ends. At least one of said protruding means is integrally formed with the band means.

Abstract: A medical pump system includes at least one medical fluid pump of a first type and at least one medical fluid pump of a second type. The medical fluid pumps can be assembled or arranged vertically, with one of the medical fluid pumps positioned above the other. Each medical fluid pump has a movable front flap with an integrated display and operating elements. The medical fluid pumps can be directly connected to one another in a vertical arrangement, or arranged in a vertical arrangement with the aid of a carrying or holding device. When the medical fluid pumps are vertically arranged, the displays and operating elements of the respective medical fluid pumps are aligned vertically.

Abstract: A medical fluid pump of the infusion or syringe pump design includes a fluid pump housing which includes a display unit, in particular a display or touch display, with a plurality of display panels that are prepared and configured to display at least one respective function parameter of the fluid pump, including at least one setting parameter which can be set directly by a user of the fluid pump and a plurality of operating parameters which cannot be set directly by the user. The representation of the at least one setting parameter stands out visually against the operating parameters, such as by displaying the at least one setting parameter in an enlarged size compared to the operating parameters.

Abstract: Aspects of the present disclosure include methods of making barcoded solid supports. In some embodiments, the methods include producing a concatemer by rolling circle amplification (RCA) of a circular nucleic acid template, where the circular nucleic acid template includes a barcode and a stem-loop forming region, and where the concatemer includes a plurality of linked units, each unit including the barcode and a stem-loop structure formed from the stem-loop forming region. Such methods further include disposing the concatemer on a solid support to produce a barcoded solid support including a plurality of the stem-loop structures extending from the surface of the solid support. The methods may further include treating the stem-loop structures with an agent that produces stem structures having ends compatible with target nucleic acids, and attaching the target nucleic acids to the stem structures. Barcoded solid supports and methods of using the barcoded solid supports are also provided.

Abstract: The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, to rescue or restore retinal function, to rescue or restore retinal structure, and/or to rescue or restore choroidal structure and/or function in chronic retinal and other disorders.