Abstract: A method for anal or stomal irrigation includes providing an irrigation system to a user and instructing the user to operate the system to expel the irrigating liquid from a catheter tip. The irrigation pressure is controlled with the control system in response to input from a sensor such that a pressure at the catheter tip approaches a predetermined threshold pressure value without exceeding the predetermined pressure value.

Abstract: In certain embodiments a lentiviral vector for the treatment of Recombination-Activating Gene 1 Severe Combined Immunodeficiency (RAG1 SCID) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising an effective fragment of the endogenous promoter of the RAG1 gene and a nucleic acid that encodes the RAG1 protein operably linked to the effective fragment of the endogenous promoter of the RAG1 gene.

Abstract: A body side member of an ostomy appliance having a distal surface with one or more pockets holding a manipulable material and allowing the manipulable material to be shifted between a first position and a second position in the pocket in use of the body side member around a stoma of a user.

Abstract: A perforated filtration insert includes a head unit and a body portion having perforated side walls. The body portion is closed at one end by a cap such that fluid entering the body exits through the perforations in the side walls of the insert.

Abstract: Disclosed is a sensor patch and a method for manufacturing a sensor patch for attachment to an adhesive surface of a base plate for an ostomy appliance. The sensor patch having a first side and a second side. The sensor patch being adapted to form a stomal opening with a centre point, the stomal opening being configured to allow passage of output through the stomal opening and into an ostomy pouch attached to a base plate. The sensor patch comprises: a sensor assembly comprising a plurality of electrodes, a first adhesive sensor layer forming the first side of the sensor patch, and a second adhesive sensor layer forming the second side of the sensor patch.

Abstract: A base plate (1) for an ostomy appliance. The base plate forms a proximal surface (2) configured to be attached to the body. The base plate comprises an electrode structure (4) extending in a recess structure (5) in the proximal surface. To allow a more exact signal, the recess structure defines volume which exceeds the volume of the electrode structure to thereby define a free space in the recess structure.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: In certain embodiments a lentiviral vector having an LCR comprising HS1 ENCODE core (EC1) sequence (SEQ ID NO:1), and one or more of an HS2 core sequence (ecHS2), an HS3 core sequence (ecHS3), an HS4 core sequence (ecHS4), a full length HS2, a full length HS3, and/or a full length HS4 sequence is provided. In certain embodiments the vector comprises a modified ?AS3-globin transgene, where transgene comprises a codon optimized exon 1, and/or a codon optimized exon 2, and/or a codon optimized exon 3.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: In certain embodiments a lentiviral vector having optimized reduced size LCR with improved enhancer activity is provided. In certain embodiments direct treatment of a subject by direct introduction of the vector(s) described herein is contemplated. The lentiviral compositions may be formulated for delivery by any available route including, but not limited to parenteral (e.g., intravenous), intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, rectal, and vaginal.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express the glycoepitope STn on TAG-72.

Abstract: Embodiments presented herein describe techniques for generating a linguistic model of input data obtained from a data source (e.g., a video camera). According to one embodiment of the present disclosure, a sequence of symbols is generated based on an ordered stream of normalized vectors generated from the input data. A dictionary of words is generated from combinations of the ordered sequence of symbols based on a frequency at which combinations of symbols appear in the ordered sequence of symbols. A plurality of phrases is generated based an ordered sequence of words from the dictionary observed in the ordered sequence of symbols based on a frequency by which combinations of words in ordered sequence of words appear relative to one another.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: We disclose a method of providing a user or a healthcare worker with an ostomy device that is shape-adjustable to conform to skin around a stoma associated with a bulge or a hernia. The ostomy device is configured to invert from a storage configuration to a use configuration by inverting a substantially convex shape of a proximal side of a base plate to a substantially concave shape and stabilizing the base plate in the use configuration by contacting the inner radial periphery of the reinforcing structure with a distal surface of the base plate.

Abstract: An adaptable ostomy base plate comprising a flexible top film, having a first section and a second section, and having at least a first elastic skin-friendly adhesive on a proximal surface of said flexible top film, a stoma-receiving through-going hole defining an inner boundary in said first section, said first section being adjacent to and extending radially from said through-going hole and said second section surrounding said first section defining an outer boundary of the base plate, and one or more release liners, the base plate has a substantially convex shape for initial engagement with a peristomal skin surface and can be inverted to a substantially concave shape to fittingly engage to a topography of the peristomal skin surface and the second section of the base plate is in the form of a plurality of petals extending away from the central area; and a plurality of bridges, each bridge formed between adjacent petals of the plurality of petals.

Abstract: Disclosed is a complementary material (20) dispenser attachable to an interior surface (30) of a top portion (28) of a collecting bag (22) for body waste to provide dispensing of complementary material (26) from the dispenser towards a material allocation zone (32) at the top portion (28) of the collecting bag. Also disclosed is an ostomy appliance system including a complementary material dispenser.