Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The present invention relates to novel peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or prevention of disorders in which aberrant cell division occurs.

Abstract: A system for anal or stomal irrigation comprises a reservoir (102) for an irrigating liquid; a catheter (100) comprising a catheter tip for insertion into the rectum or stoma, a thermo sensor (128) connected to the reservoir for obtaining a measure of a temperature within the reservoir, a tubing system and/or the catheter. A control system (103) operatively connected with the thermo sensor is configured to determine a temperature within the reservoir. A method for predicting a temperature in a reservoir for irrigation liquid is also provided.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.

Abstract: The present invention relates to compounds of Formula I or a pharmaceutically salt or solvate thereof, which impair PBX-dependent transcription regulation, particularly which affect the binding of HOX to PBX and their use in a number of applications, including the reduction of aberrant cell division, e.g. to treat certain cancers, and to maintain pluripotency of stem cells, e.g. to maintain the pluripotency of stem cells during culture expansion. wherein R1, R2 and R3 are as defined herein.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention relates to an insertion device comprising —a penetrating member (50) connected to transformation means (52), —a moving part (38) comprising guiding means (39) which guiding means (39) restrict the movement of the transformation means (52) and guide the penetrating member (50) from a first to a second position in a first direction, i.e. the direction of insertion, towards the injection site, and —a stationary housing (30) comprising guiding means (32) which guiding means (32) restrict the movement of the moving part (38). The guiding means (32) guide the moving part (38) in a second direction which is linear and different from the first direction i.e. the direction of insertion.

Abstract: An anal irrigation system including a control unit (2) is provided. The control unit (2) is connected to an external tube (4) by an extension cord (9), so that pivoting of the control unit (2) with respect to the external tube (4) is possible.

Abstract: An energy monitoring system includes a memory storing instructions to execute an energy modeling technique and processing circuitry for executing the instructions to operate the energy modeling technique. The energy modeling technique includes receiving energy data from a plurality of segments representative of one or more logical subgroups. The energy modeling technique includes categorizing the energy data of the logical subgroups into a plurality of segments. The energy modeling technique includes organizing the plurality of segments into a plurality of state-based hierarchical levels. The energy modeling technique includes calculating energy usage and factors associated with the plurality of state-based hierarchical levels via an energy model. The energy modeling technique includes outputting a visualization representative of the energy data corresponding to each of the segments to a monitoring and control system, resulting in a graphical representation accessible by a user-viewable screen.

Abstract: Embodiments presented herein describe techniques for generating a linguistic model of input data obtained from a data source (e.g., a video camera). According to one embodiment of the present disclosure, a sequence of symbols is generated based on an ordered stream of normalized vectors generated from the input data. A dictionary of words is generated from combinations of the ordered sequence of symbols based on a frequency at which combinations of symbols appear in the ordered sequence of symbols. A plurality of phrases is generated based an ordered sequence of words from the dictionary observed in the ordered sequence of symbols based on a frequency by which combinations of words in ordered sequence of words appear relative to one another.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express the glycoepitope STn on TAG-72.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: Embodiments presented herein describe techniques for generating a linguistic model of input data obtained from a data source (e.g., a video camera). According to one embodiment of the present disclosure, a sequence of symbols is generated based on an ordered stream of normalized vectors generated from the input data. A dictionary of words is generated from combinations of the ordered sequence of symbols based on a frequency at which combinations of symbols appear in the ordered sequence of symbols. A plurality of phrases is generated based an ordered sequence of words from the dictionary observed in the ordered sequence of symbols based on a frequency by which combinations of words in ordered sequence of words appear relative to one another.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: The present invention relates to novel peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or prevention of disorders in which aberrant cell division occurs.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.

Abstract: A urinary catheter assembly having a sleeve is provided. The urinary catheter assembly comprises a urinary catheter (2) having a hydrophilic surface; the urinary catheter being provided with an insertion tip (5) in a proximal insertion end of the urinary catheter and an outlet (4) at a distal end of the urinary catheter, a handle (8) being slidingly disposed on the urinary catheter, a collapsible, flexible sleeve (7) attached to the handle and being configured to cover the urinary catheter from the outlet to the tip portion in an extended configuration of the urinary catheter assembly, the sleeve being attached to a connector (9) at the outlet, the connector and handle configured to be detachably attached to each other and define a cavity provided by the sleeve, handle and connector encapsulating an entirety of the urinary catheter in a storage condition.