Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agents selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.

Abstract: A method and system of ozone treatment diverts a portion of water from a flow of water in a conduit; injects an ozone-containing gas into the portion to provide an ozonated portion; recombines the ozonated portion with the flow of water in the conduit; and regulates the diverted portion to provide a minimum diverted portion flow rate according to flow in the conduit and proportion of ozone in the injected gas.

Abstract: A method and system of ozone treatment diverts a portion of water from a flow of water in a conduit; injects an ozone-containing gas into the portion to provide an ozonated portion; recombines the ozonated portion with the flow of water in the conduit; and controls and regulates the diverted portion to provide a minimum diverted portion flow rate according to flow in the conduit and proportion of ozone in the injected gas.

Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: An adjustable spinal implant (10) is provided for use in connecting elongate members (12) as well as vertebral spacers such as corpectomy devices, intervertebral fusion devices, and other prostheses. The implant (10) may have fittings (80) on either end comprising fixed (100) or articulating (200) jaws, endplates, or other engagement structures. The implant (10) comprises a housing (40) with an internal rotor (60); an extending shaft (20); and a locking collar (70). The extending shaft (20) has an external helical groove (23) that meshes with an internal helical groove (63) on rotor (20). Length adjustment occurs by transforming axial movement of the extending shaft (20) into a rotary movement of the rotor (60) via helical engagement. The locking collar (70) comprises protrusion (73) engaging grooves (63) of rotor (60), thus providing a simple, positive locking mechanism without requiring the surgeon to apply excessive force to lock the length.

Abstract: A spinal rod bone anchor (00) having a proximal end for engaging a rod (200) and securing the rod with a coming or threaded lock assembly (300) and a distal end for engaging bone. A locking device (300) received within two flanges (110, 120) having an upper wave cap (310) and a lower cap (330) joined by a post with preset timing grooves (335) therein and having camming surfaces therebetween (317, 338).

Abstract: An adjustable spinal implant 10 is provided for use in connecting elongate members 12 as well as in vertebral spacers such as corpectomy devices, intervertebral fusion devices, and other prostheses. The implant 10 may have fittings 80 on either end comprising fixed 100 or articulating jaws 200, endplates, or other engagement structures. The implant 10 comprises a housing 40 with an internal rotor 60; an extending shaft 20; and a locking collar 70. The extending shaft 20 has an external helical groove 23 that meshes with an internal helical groove 63 on the rotor 20. Length adjustment occurs by transforming axial movement of the extending shaft 20 into a rotary movement of the rotor 60 via helical engagement. The locking collar 70 comprises protrusion 73 engaging grooves 63 of rotor 60, thus providing a simple, positive locking mechanism without requiring the surgeon to apply excessive force to lock the length.

Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: An instrument guide and implant holding device is provided which releasably secures an implant to the instrument guide. The device provides a convenient guide for surgeons to perform various operative techniques on the subject bone without the need for separate devices, and allows all these operative techniques to be performed without removing the instrument guide from the dissected area until all operative techniques have been completed. The releasable mechanism allows the surgeon to easily hold the instrument to an implant using a simple press-fit approach, and easily releases from the implant with a minimal amount of force. An embodiment also allows the surgeon to releasably lock the cannula in a given orientation about the centroidal axis of the implant fastener hole.

Abstract: ?- and ?-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: A biopsy assembly suitable for marking of a biopsy site and providing a cut down guide. The assembly includes a pliable filament having an indicator for marking the biopsy site and a stiffener guidable along the filament to provide a cut down guide.

Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors:

Abstract: ?- and ?-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: HIV protease inhibitors are disclosed which are characterized as having both hydroxyethylamine and N-heterocyclic moieties.

Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: HIV protease inhibitors are disclosed which are characterized as having both hydroxyethylamine and N-heterocyclic moieties.

Abstract: A method and system treat ballast-water with ozone without release of detrimental off-gas into the atmosphere.

Abstract: A method and system of ozone treatment diverts a portion of water from a flow of water in a conduit, injects ozone into the portion to provide an ozonated portion, and recombines the ozonated portion with the flow of water in the conduit. Another method and system identifies a species-destructive reaction product of ozone with a water constituent, determines a life of the reaction product, and contacts ozone with a water containing the species for a period determined according to the determined life of the reaction product.