Patents by Inventor Richard A. Soltero

Richard A. Soltero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190183883
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Anthony A. McKinney, Gary Tollefson, Richard Soltero, Thea Elise Dunzo
  • Publication number: 20170014404
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: September 28, 2016
    Publication date: January 19, 2017
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Publication number: 20160158225
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: February 17, 2016
    Publication date: June 9, 2016
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Publication number: 20160158221
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: August 13, 2015
    Publication date: June 9, 2016
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Patent number: 9107837
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: August 18, 2015
    Assignee: Orexigen Therapeutics, Inc.
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Publication number: 20150080424
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: November 26, 2014
    Publication date: March 19, 2015
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Patent number: 8916195
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: December 23, 2014
    Assignee: Orexigen Therapeutics, Inc.
    Inventors: Anthony A. McKinney, Gary D. Tollefson, Richard Soltero, Thea Elise Dunzo
  • Patent number: 7635675
    Abstract: Fatty acid salt particles having a size distribution wherein the particles are from about 1 to about 1,000 microns in diameter, use of the particles in pharmaceutical compositions, as well as methods of making and using the particles and compositions.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: December 22, 2009
    Assignee: Biocon Limited
    Inventors: Foyeke Opawale, Richard Soltero
  • Patent number: 7611864
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also described as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates are also described.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: November 3, 2009
    Assignee: Biocon Limited
    Inventors: Balasingam Radhakrishnan, Richard Soltero, Nnochiri N. Ekwuribe
  • Publication number: 20080226705
    Abstract: The invention relates to a swallowable delivery device fabricated from a composition including a hydrated polymeric matrix with gelatinous consistency, one or more active ingredients, and optionally one or more stiffening agent. The delivery device is of a size and shape amenable to swallowing with enhanced solubility and controlled release of the active ingredients.
    Type: Application
    Filed: April 3, 2008
    Publication date: September 18, 2008
    Inventors: Richard A. Soltero, Thomas J. Colatsky
  • Patent number: 7368260
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also described as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates are also described.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: May 6, 2008
    Assignee: Biocon Limited
    Inventors: Balasingam Radhakrishnan, Richard Soltero, Nnochiri N. Ekwuribe
  • Publication number: 20080097804
    Abstract: A method for developing and managing a manufacturing process may include presenting a graphical user interface to define a project for developing and managing the manufacturing process for a product and storing the data entered to define the project in a database. The method may also include presenting a graphical user interface to at least one process development participant for entering data related to developing and managing the manufacturing process and storing the data related to developing and managing the manufacturing process in the database. The method may further include presenting selected data related to developing and managing the manufacturing process. In accordance with another embodiment of the present invention, a quality assurance system may be associated with the manufacturing process. The method may also include developing and managing the manufacturing process and the quality assurance system which may be integrated in the manufacturing process.
    Type: Application
    Filed: September 25, 2007
    Publication date: April 24, 2008
    Inventor: Richard Soltero
  • Patent number: 7312192
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also provided as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates and other pro-polypeptide-oligomer conjugates are also provided.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: December 25, 2007
    Assignee: Biocon Limited
    Inventors: Balasingam Radhakrishnan, Richard Soltero, Nnochiri N. Ekwuribe, Monica Puskas, Diti Sangal
  • Publication number: 20070281021
    Abstract: A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
    Type: Application
    Filed: June 4, 2007
    Publication date: December 6, 2007
    Applicant: OREXIGEN THERAPEUTICS, INC.
    Inventors: Anthony McKinney, Gary Tollefson, Richard Soltero, Thea Dunzo
  • Publication number: 20070196495
    Abstract: The present invention is a variably thickened pharmaceutical dosage form, its composition and its use for orally administering medications to patients that have difficulty swallowing other solid dosage forms such as tablets or capsules.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 23, 2007
    Inventor: Richard Soltero
  • Patent number: 7196059
    Abstract: Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: March 27, 2007
    Assignee: Biocon Limited
    Inventors: Richard Soltero, Balasingam Radhakrishan, Nnochiri N. Ekwuribe, Bruce Rehlaender, Anthony Hickey, Li Li Bovet
  • Patent number: 7166571
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also provided as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates and other pro-polypeptide-oligomer conjugates are also provided.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: January 23, 2007
    Assignee: Biocon Limited
    Inventors: Richard Soltero, Balasingam Radhakrishnan, Nnochiri N. Ekwuribe
  • Patent number: 7030082
    Abstract: Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1 or any value between. Methods of treating diseases in a subject in need of such treatment using the pharmaceutical compositions of this invention are also provided, as well as methods of providing such pharmaceutical compositions.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: April 18, 2006
    Assignee: Nobex Corporation
    Inventors: Richard Soltero, Nnochiri N. Ekwuribe, Foyeke Opawale, Bruce Rehlaender, Anthony Hickey, Li Li Bovet
  • Publication number: 20050277580
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also described as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates are also described.
    Type: Application
    Filed: July 5, 2005
    Publication date: December 15, 2005
    Inventors: Balasingam Radhakrishnan, Richard Soltero, Nnochiri Ekwuribe
  • Patent number: 6913903
    Abstract: Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also described as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates are also described.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: July 5, 2005
    Assignee: Nobex Corporation
    Inventors: Richard Soltero, Balasingam Radhakrishnan, Nnochiri N. Ekwuribe