Patents by Inventor Richard B. Hochberg

Richard B. Hochberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Estradiol-16&agr;-carboxylic acid esters as locally active estrogens
    Patent number: 6476012
    Abstract: The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16&agr;-carboxylic acid substituted steroids and their esters is presented which exhibit excellent biological activity for use in pharmaceutical compositions for the treatment of symptomology associated with menopause. The present invention is therefore directed to compounds according to the structure: Where R is H, a C1 to C5 alkyl, vinyl, CF3, CH2CH2F, CH2CHF2 or CH2CF3; and m is from 0-2, or a pharmaceutically acceptable salt thereof. Preferably, R is methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, pentyl, neo-pentyl, vinyl, CF3, CH2CH2F, CH2CHF2 or CH2CF3 and m is 0. More preferably, R is methyl, ethyl, CH2CH2F, CH2CHF2 or CH2CF3 and m is 0.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: November 5, 2002
    Assignee: Yale University
    Inventor: Richard B. Hochberg
  • Estradiol-16alpha-carboxylic acid esters as locally active estrogens
    Publication number: 20020143002
    Abstract: The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16&agr;-carboxylic acid substituted steroids and their esters is presented which exhibit excellent biological activity for use in pharmaceutical compositions for the treatment of symptomology associated with menopause.
    Type: Application
    Filed: January 23, 2002
    Publication date: October 3, 2002
    Inventor: Richard B. Hochberg
  • 16.alpha. Halogen substituted 3,17.beta.-dihydroxy steroidal estrogens
    Patent number: 4465676
    Abstract: 16.alpha.-Radiohalo-3,17.beta.-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16.beta.-bromo compound. The radiolabelled estrogens of this invention are useful in estrogen receptor assays, radioimmunoassays, in vivo imaging of tissue having estrogen receptor activity, and for therapeutic treatment of tumors having estrogen receptor activity.
    Type: Grant
    Filed: April 9, 1980
    Date of Patent: August 14, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Richard B. Hochberg