Patents by Inventor Richard Barner

Richard Barner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensory layers
    Patent number: 5986066
    Abstract: A biologically recognizing layer on a solid phase consisting of biologically recognizing molecules comprising regions which recognize a substance to be analyzed and regions which do not recognize a substance to be analyzed.The biologically recognizing molecules are aligned on a suitably modified surface by means of molecular regions which do not recognize the substance to be analyzed. The biologically recognizing molecules are cross-linked with the aligning surface and are consequently covalently altered. The molecular regions recognizing the substance to be analyzed are not altered by the covalent bonding and retain their bonding activity.The layer is produced in a novel two-stage method. In the first step, the biologically recognizing molecules, the aligning molecules and carrier molecules are adsorbed. In the second step, the molecules are covalently anchored by cross-linking. Cross-linking is brought about by photolytic activation of a water soluble reagent bonded to the carrier molecules.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: November 16, 1999
    Assignee: Roche Diagnostics Corporation
    Inventors: Richard Barner, Walter Huber, Josef Hubscher, Jurg Hurst, Daniel Schlatter
  • Heterotrifunctional compounds for photoaffinity labelling
    Patent number: 5646302
    Abstract: The invention is concerned with novel heterotrifunctional compounds which contain a chemically reactive group R, a photochemically reactive group Ar--N.sup.3 and a reductively cleavable S--S(X.sub.2)-group. The chemically reactive group and the photochemically reactive group are separated by a spacer group which contains a disulfide group. The water-solubilizing groups are carboxylic acids and sulfonic acids or derivatives thereof which are attached either to the aromatic ring or to the spacer group between the aromatic ring and the cleavable SS group. The compounds facilitate a novel photoaffinity method for the labelling of biomolecules, whereby the labelled biomolecule preserves its water solubility and the labelling molecule preferably projects free into the solution after anchorage to the surface of the biomolecule.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: July 8, 1997
    Assignee: Roche Diagnostic Systems, Inc.
    Inventors: Richard Barner, Walter Huber, Josef Hubscher, Jurg Hurst, Daniel Schlatter
  • Dioxolanes
    Patent number: 5283346
    Abstract: Alcohols of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently methyl or ethyl or together signify pentamethylene, formed by the enzymatic hydrolysis of a corresponding (RS) alkanoic acid ester are intermediates for Vitamin E.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: February 1, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josepf Hubscher, Beat Wirz
  • Process for the production of dioxolanes
    Patent number: 5232852
    Abstract: Alcohols of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently methyl or ethyl or together signify pentamethylene,formed by the enzymatic hydrolysis of a corresponding (RS) alkanoic acid ester are intermediates for Vitamin E.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: August 3, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josepf Hubscher, Beat Wirz
  • Glycerin derivatives
    Patent number: 5187293
    Abstract: Glycerine derivatives of the formula ##STR1## wherein the residues R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description, and their hydrates, which inhibit blood platelet activating factor (PAF), are described.
    Type: Grant
    Filed: November 19, 1987
    Date of Patent: February 16, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Kaspar Burri, Jean-Marie Cassal, Paul Hadvary, Georges Hirth, Klaus Muller
  • Vitamin E intermediates and a process for their manufacture and conversion into vitamin E
    Patent number: 5153344
    Abstract: Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: October 6, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Glycerol derivatives
    Patent number: 5057530
    Abstract: Glycerol derivatives of the formula ##STR1## wherein one of the residues R.sup.1, R.sup.2 and R.sup.3 is a group U of the formula OY.sup.1 or --X.sup.1 --CO--(A.sup.1).sub.n --Z.sup.1, another residue is a group V of the formula OY.sup.2 or --X.sup.2 --CO--(A.sup.2).sub.p --Z.sup.2, and the remaining residue is a group W of the formula --X.sup.3 T--(C.sub.2-6 -alkylene)-N.sup.+ R A.sup.- in which one of X.sup.1, X.sup.2 and X.sup.3 is oxygen or NQ.sup.1 and the other two are oxygen and the remaining symbols have the significance given below, and their hydrates are described and are prepared by introducing or generating the residues R.sup.1, R.sup.2 and R.sup.3 in corresponding glycerol derivatives.The compounds of formula I are active as inhibitors of blood platelet activating factor or as inhibitors of the growth of tumors.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: October 15, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Kaspar Burri, Jean-Marie Cassal, Paul Hadvary, Georges Hirth, Klaus Muller
  • Novel vitamin E intermediates and a process for their manufacture and conversion into vitamin E
    Patent number: 5034546
    Abstract: Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: July 23, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Vitamin E intermediates and a process for their manufacture and conversion into Vitamin E
    Patent number: 4996375
    Abstract: Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: February 26, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Process for synthesizing chromanes
    Patent number: 4958035
    Abstract: The present invention is directed to a novel process for producing chromane derivatives, which are suitable as intermediates for the manufacture of d-.alpha.-tocopherol (natural vitamin E), and with a process for producing d-.alpha.-tocopherol itself.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: September 18, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Hydroquinone derivatives and a process for their preparation
    Patent number: 4904823
    Abstract: There is described a process for the manufacture of hydroquinone derivatives of the formulae ##STR1## which are valuable intermediates in the synthesis of natural vitamin E.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: February 27, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Process for synthesizing chromanes
    Patent number: 4876369
    Abstract: The present invention is directed to a novel process for producing chromane derivatives, which are suitable as intermediates for the manufacture of d-.alpha.-tocopherol (natural vitamin E), and with a process for producing d-.alpha.-tocopherol itself.
    Type: Grant
    Filed: August 23, 1988
    Date of Patent: October 24, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Glycerol derivatives
    Patent number: 4863941
    Abstract: Glycerol derivatives of the formula ##STR1## wherein one of the residues R.sup.1, R.sup.2 and R.sup.3 is a group U of the formula OY.sup.1 or --X.sup.1 --CO--(A.sup.1).sub.n --Z.sup.1, another residue is a group V of the formula OY.sup.2 or --X.sup.2 --CO--(A.sup.2).sub.p --Z.sup.2, and the remaining residue is a group W of the formula --X.sup.3 T--(C.sub.2-6 -alkylene)-N.sup.+ R A.sup.- in which one of X.sup.1, X.sup.2 and X.sup.3 is oxygen or NQ.sup.1 and the other two are oxygen and the remaining symbols have the significance given below, and their hydrates are described and are prepared by introducing or generating the residues R.sup.1, R.sup.2 and R.sup.3 in corresponding glycerol derivatives.The compounds of formula I are active as inhibitors of blood platelet activating factor or as inhibitors of the growth of tumors.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: September 5, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Kaspar Burri, Jean-Marie Cassal, Paul Hadvary, Georges Hirth, Klaus Muller
  • Vitamin E intermediates
    Patent number: 4851585
    Abstract: Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
    Type: Grant
    Filed: November 12, 1987
    Date of Patent: July 25, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Hydroquinone derivatives
    Patent number: 4824972
    Abstract: Compounds of the general formula ##STR1## wherein R represents an ether protecting group and R.sup.1 is a group of (a)-(d) useful as intermediates.
    Type: Grant
    Filed: January 19, 1988
    Date of Patent: April 25, 1989
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Process for the preparation of hydroquinone derivatives and d-.alpha.-tocopherol
    Patent number: 4808736
    Abstract: In this process of the invention a compound of the formula ##STR1## wherein R is a leaving group, is reacted with a compound of the formula ##STR2## wherein R.sup.1 is an ether protecting group, and, if desired a thus-obtained compound of the formula ##STR3## is converted in a known manner into d-.alpha.-tocopherol.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Hydroquinone derivatives and a process for their preparation
    Patent number: 4743696
    Abstract: Compounds of the general formula ##STR1## wherein R represents an ether protecting group and R.sup.3 is a group of (f)-(i) useful as intermediates.
    Type: Grant
    Filed: March 5, 1987
    Date of Patent: May 10, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Glycerin derivatives and inhibition of blood PAF
    Patent number: 4731373
    Abstract: Glycerine derivatives of the formula ##STR1## wherein the residues R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description,and their hydrates, which inhibit blood platelet activating factor (PAF), are descried.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: March 15, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: Richard Barner, Kasper Burri, Jean-Marie Cassal, Paul Hadvary, Georges Hirth, Klaus Muller
  • (Alkoxy-methyl)-phenyl-methyl-epoxybutanes
    Patent number: 4709055
    Abstract: There is described a novel process for producing hydroquinone derivatives of the formula ##STR1## wherein R is an ether protecting group, and their conversion into d-.alpha.-tocopherol, starting from compounds of the formula ##STR2## wherein R is an ether protecting group and R.sup.1 is hydrogen or an ether protecting group.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: November 24, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Hydroquinone derivatives and a process for their preparation
    Patent number: 4675421
    Abstract: Compound of the general formula ##STR1## wherein R represents an ether protecting group useful as intermediates.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: June 23, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher