Patents by Inventor Richard Benarous

Richard Benarous has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9604900
    Abstract: The present invention relates to aromatic carbocycle or heterocycle compounds comprising an acid function and being of formula (5), wherein W, Q1, Q2, Q3, Q4, R1, R3, R4, R7, R9, R11, a, c, e, and g are as described in the description; and the use of such compounds in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: March 28, 2017
    Assignee: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9562033
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: February 7, 2017
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
    Publication number: 20160375127
    Abstract: A novel method for producing an immunogenic composition or vaccine comprising inactivated lentivirus, in particular inactivated HIV, wherein producer cells producing, preferably constituvely producing lentivirus particles are provided, the lentivirus particles are produced by these producer cells in the presence of an antiretroviral (ARV) agent which is an inhibitor of the IN-LEDGF/p75 interaction, the inactivated lentivirus is recovered and formulated in a pharmaceutically acceptable vehicle or carrier. The invention also relates to immunogenic compositions or vaccines and to methods for the therapeutic or prophylactic treatment of a mammal, especially a human, and various therapy combinations involving the administration of said immunogenic compositions or vaccines.
    Type: Application
    Filed: July 7, 2014
    Publication date: December 29, 2016
    Inventors: Richard BENAROUS, Erwann LE ROUZIC, Jean-Michel BRUNEAU, Damien BONNARD, François MOREAU
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9475802
    Abstract: Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 25, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9260395
    Abstract: The present invention relates to compounds of formula (I), their the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: February 16, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20160039783
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 7, 2013
    Publication date: February 11, 2016
    Inventors: Richard BENAROUS, Francis CHEVREUIL, Benoit LEDOUSSAL, Sophie CHASSET, Frédéric LE STRAT
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9238026
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 19, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20150274673
    Abstract: The present invention relates to compounds of formula (I), their the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 7, 2013
    Publication date: October 1, 2015
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20150274718
    Abstract: Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Applicant: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
    Publication number: 20140128383
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: April 6, 2012
    Publication date: May 8, 2014
    Applicant: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
    Publication number: 20140031338
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 30, 2014
    Applicant: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Human immunodeficiency virus integrase—Transportin—SR protein—protein interactions
    Patent number: 8197821
    Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: June 12, 2012
    Assignee: Laboratoire Biodim
    Inventors: Pierre Legrain, Jean-Christophe Rain, Richard Benarous, Stéphane Emiliani, Clarissa Berlioz-torrent, Guillaume Blot
  • NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS
    Publication number: 20120022054
    Abstract: The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.
    Type: Application
    Filed: December 10, 2009
    Publication date: January 26, 2012
    Applicant: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Sabine Barbey-Treve, Jean-Marc Paris, Sebastien Berrut, Clarisse Berlioz-Torrent, Stephane Emiliani
  • Human immunodeficiency virus integrase-LEDGF p75 isoform protein-protein interactions
    Patent number: 7763254
    Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: July 27, 2010
    Assignee: Cellvir
    Inventors: Pierre Legrain, Jean-Christophe Rain, Richard Benarous, Stéphane Emiliani, Clarissa Berlioz-torrent, Guillaume Blot
  • Protein-protein interactions in human immunodeficiency virus
    Publication number: 20090004719
    Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
    Type: Application
    Filed: February 25, 2008
    Publication date: January 1, 2009
    Applicant: Cellvir
    Inventors: Pierre Legrain, Jean-Christophe Rain, Richard Benarous, Stephane Emiliani, Clarissa Berlioz-torrent, Guillaume Blot
  • Protein-protein interactions in human immunodeficiency virus
    Publication number: 20060034860
    Abstract: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs of agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
    Type: Application
    Filed: May 26, 2004
    Publication date: February 16, 2006
    Applicant: Hybrigenics
    Inventors: Pierre Legrain, Jean-Christophe Rain, Richard Benarous, Stephane Emiliani, Clarissa Berlioz-torrent, Guillaume Blot
  • Human &bgr;TrCP protein
    Patent number: 6730486
    Abstract: The present invention relates to the human &bgr;TrCP protein for the targeting of proteins towards proteasome degradation pathways, which is capable of interacting with the Vpu protein of HIV-1 virus, with the cell proteins I&kgr;B and &bgr;-catenin and with the cell protein Skp1p, to its peptide fragments and to the nucleic acid sequences coding for said protein and its fragments. It further relates to the use of the human &bgr;-TrCP protein or its peptide fragments for the screening of anti-HIV-1 antiviral agents, antitumoral agents and anti-inflammatory agents, to the antiviral agents, antitumoral agents and anti-inflammatory agents, and to the antibodies directed against said protein and its peptide fragments.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: May 4, 2004
    Assignees: Institut National de la Sante et de la Recherche Medicale, Institut Pasteur
    Inventors: Richard Benarous, Florence Margottin, Hervé Durand, Fernando Arenzana Seisdedos, Mathias Kroll, Jean-Paul Concordet
  • Proteins that interact with betaTrCP
    Publication number: 20030007956
    Abstract: The present invention relates to proteins that interaction with &bgr;TrCP. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
    Type: Application
    Filed: December 18, 2001
    Publication date: January 9, 2003
    Inventors: Pierre Legrain, Richard Benarous, Guillaume Blot, Irina Lassot