Abstract: A method and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.

Abstract: Production of oxygen-enriched gas streams is disclosed herein. Air streams contact an oxygen-selective mixed conductor particularly a perovskite material whereby oxygen is retained or adsorbed on the perovskite and can be employed in a variety of processes such as in combusting a fuel gas, heat recovery and boiler related operations.

Abstract: An article of footwear includes a flexible cover shaped to envelope at least a portion of a wearer's foot. The cover has a sole region with inner and outer surfaces, the inner surface positioned to face the sole of the wearer's foot and the outer surface positioned to face in an opposite direction. The cover also has a plurality of apertures formed in the sole region. The article further includes a removable outsole nested within the cover. The outsole has an upper surface positioned to face the sole of the wearer's foot, a lower surface facing the inner surface of the cover sole region, and a plurality of lugs on the lower surface which protrude into the plurality of apertures.

Abstract: The present invention provides low-resolution Raman spectroscopic systems and methods for in situ monitoring of drug-eluting devices in a lumen of a subject. A preferred system can employ multi-mode radiation in making in situ Raman spectroscopic measurements of the lumen and/or device. For example, a system can include a light source such as a multi-mode laser, and a light detector to measure spectral patterns and differentiates spectral features of drugs released in a target region. Drug-release curves can be extrapolated or otherwise predicted using the Raman spectrum taken during or subsequent to device insertion and/or activation.

Abstract: A multi purpose hand tool includes an elongate generally cylindrical handle having opposite first and second ends. The handle is adapted for grasping by a user and has a hole through the handle located substantially mid-way along the length of the handle. The hole extends through the handle so that a digit of the user's hand, when grasping the handle, may be inserted through the hole.

Abstract: A coated surface that resists cell adhesion comprises hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).

Abstract: A multi purpose hand tool includes an elongate generally cylindrical handle having opposite first and second ends. The handle is adapted for grasping by a user and has a hole through the handle located substantially mid-way along the length of the handle. The hole extends through the handle so that a digit of the user's hand, when grasping the handle, may be inserted through the hole.

Abstract: A data storage medium 10 adapted to restrict access to data 20 stored thereupon by encrypting control login 18, 22 which directs storage devices 62, 64 where to look for the data 20 on the storage medium 10 and a method for providing such a storage medium 10.

Abstract: A storage device includes a trusted clock, a memory, a time-stamper and a digital signer. The device is adapted to store to the memory data that has been time-stamped by the time-stamper, with a time obtained from the trusted clock, and digitally signed with a digital signature by the digital signer.

Abstract: A RAID device is provided with a pair of non-volatile solid state data storage devices and one or more rotating disk drives, giving improved access time performance to the array. Data is staged on the pair of solid state data storage devices, and periodically backed up to the rotating disk drive(s).

Abstract: An article irradiation system includes a radiation source for scanning a target region with radiation; a first conveyor system for transporting articles from a loading area though the target region to an unloading area; and radiation shielding material defining a tunnel closely encompassing portions of the conveyor system extending away from the target region toward the loading and unloading areas for shielding the loading and unloading areas from radiation derived from the radiation source. The first conveyor system is disposed in a path having curved turns of such degree between the target region and the loading and unloading areas that the closely encompassing radiation shielding material precludes a direct line of sight between the target region and the loading and unloading areas and thereby facilitates a compact embodiment in which the first conveyor system may be included in an assembly line.

Abstract: A technique for percutaneous treatment of idiopathic hypertrophic subaortic stenosis (IHSS) and hypertrophic cardiomyopathy (HCM). IHSS and HCM are diseases of the heart in which the septum of the left ventricle thickens resulting in reduced ventricular performance. Current treatments involve drug therapy or a medical intervention called an interoperative myotomy/myectomy using the Morrow procedure. The present invention uses laser energy delivered via fiber optics placed percutaneously to irradiate the thickened septum to reduce tissue volume of the septum and enhance left ventricular function.

Abstract: A technique for the treatment of ventricular tachycardia. The ventricles are endocardially mapped by way of an electrophysiological workup. This mapping locates the tachycardial foci and other abnormalities in conduction. A special catheter containing an optical fiber is percutaneously inserted into a blood vessel and advanced into the ventricle. The distal tip of the catheter is positioned adjacent to each of the tachycardia generating sites. A medical laser is used to irradiate each site via the optical fiber. The tissue at each site is thereby photocoagulated or ablated to remove the source of the tachyarythmia.

Abstract: A technique for percutaneous treatment of idiopathic hypertropic subaortic stenosis (IHSS) and hypertrophic cardiomyopathy (HCM). IHSS and HCM are diseases of the heart in which the septum of the left ventricle thickens resulting in reduced ventricular performance. Current treatments involve drug therapy or a medical intervention called an interoperative myotomy/myectomy using the Morrow procedure. The present invention uses laser energy delivered via fiber optics placed percutaneously to irradiate the thickened septum to reduce tissue volume of the septum and enhance left ventricular function.

Abstract: A technique for the treatment of ventricular tachycardia. The ventricles are endocardially mapped by way of an electrophysiological workup. This mapping locates the tachycardial foci and other abnormalities in conduction. A special catheter containing an optical fiber is percutaneously inserted into a blood vessel and advanced into the ventricle. The distal tip of the catheter is positioned adjacent to each of the tachycardia generating sites. A medical laser is used to irradiate each site via the optical fiber. The tissue at each site is thereby photocoagulated or ablated to remove the source of the tachyarythmia.