Patents by Inventor Richard E. Mewshaw

Richard E. Mewshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 7067524
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: June 27, 2006
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
    Patent number: 7041683
    Abstract: Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: May 9, 2006
    Assignee: Wyeth
    Inventors: George E. M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenathrene
    Patent number: 7030245
    Abstract: Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: April 18, 2006
    Assignee: Wyeth
    Inventors: Rulin Zhao, Megan Tran, Gary P. Stack, Richard E. Mewshaw
  • Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Patent number: 6930109
    Abstract: Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: August 16, 2005
    Assignee: Wyeth
    Inventors: Rulin Zhao, Megan Tran, Gary P. Stack, Richard E. Mewshaw
  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 6914074
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Patent number: 6903110
    Abstract: Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: June 7, 2005
    Assignee: Wyeth
    Inventors: Rulin Zhao, Megan Tran, Gary P. Stack, Richard E. Mewshaw
  • Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Publication number: 20040235851
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Applicant: WYETH
    Inventors: Rulin Zhao, Megan Tran, Gary P. Stack, Richard E. Mewshaw
  • Substituted phenyl naphthalenes as estrogenic agents
    Publication number: 20040225123
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: March 18, 2004
    Publication date: November 11, 2004
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Leo M. Albert, Eric S. Manas
  • Piperazinyl-isatins
    Patent number: 6743796
    Abstract: This invention provides compounds of formula VI wherein Y is hydrogen, methyl, methoxy, methylthio or trifluoromethyl; R is hydrogen, C1-3alkyl or (CH2)nAr; n is 0, 1 or 2; and Ar is phenyl or methoxyphenyl, or a pharmaceutically acceptable salt thereof. These compounds are selective dopamine autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems. The invention also comprises intermediate compounds, compositions and methods related to the compounds of formula VI.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: June 1, 2004
    Assignee: Wyeth
    Inventors: Lynne P. Greenblatt, Ivo Jirkovsky, Richard E. Mewshaw
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Patent number: 6723747
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 20, 2004
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
    Publication number: 20030236241
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 17, 2003
    Publication date: December 25, 2003
    Applicant: Wyeth
    Inventors: George E.M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Substituted phenyl naphthalenes as estrogenic agents
    Publication number: 20030181519
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 25, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Publication number: 20030176491
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
  • Aryloxy piperidinyl derivatives for the treatment of depression
    Patent number: 6610712
    Abstract: This invention provides compounds useful in treating serotonin-related central nervous system disorders, including anxiety, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, sleep disorders, sexual dysfunction, alcohol and drug addiction, Alzheimer's disease, Parkinson's disease, obesity and migraine, the compounds having the general formula: wherein: R1 and R2 may each be H or an alkyl or alkoxy group; or R1 and R2 may be concatenated to form a bicyclic ring system with the phenyl ring to which they are bound; X is selected from hydrogen, halogen, cyano, C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 0, 1 or 2; the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: August 26, 2003
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Dahui Zhou, Ping Zhou
  • Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
    Patent number: 6559169
    Abstract: Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: May 6, 2003
    Assignee: Wyeth
    Inventors: George E. M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Publication number: 20030078268
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: July 24, 2002
    Publication date: April 24, 2003
    Applicant: Wyeth
    Inventors: Rulin Zhao, Megan Tran, Richard E. Mewshaw, Gary P. Stack
  • 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
    Patent number: 6541501
    Abstract: Compounds of the Formula (I): are useful in the treatment of disorders associated with brain dopamine dysregulation.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: April 1, 2003
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Rulin Zhao
  • 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
    Patent number: 6541502
    Abstract: Compounds of the Formula (I): are useful in the treatment of disorders associated with dopamine dysregulation.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: April 1, 2003
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Rulin Zhao
  • 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
    Publication number: 20030037701
    Abstract: Compounds of the Formula (I): 1
    Type: Application
    Filed: July 18, 2002
    Publication date: February 27, 2003
    Applicant: wyeth
    Inventors: Richard E. Mewshaw, Rulin Zhao
  • Piperazinyl-isatins
    Publication number: 20030013722
    Abstract: This invention provides compounds of formula VI 1
    Type: Application
    Filed: May 3, 2002
    Publication date: January 16, 2003
    Applicant: Wyeth
    Inventors: Lynne P. Greenblatt, Ivo Jirkovsky, Richard E. Mewshaw