Patents by Inventor Richard Francis Day
Richard Francis Day has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210308682Abstract: We describe instruments, and cartridges therefor, for processing droplets of water in oil-in-water emulsions, the droplets containing biological entities such as cells. In one embodiment a method of such processing comprises: providing a plurality of the entities in a fluid: preparing a droplet from said fluid: determining whether said droplet contains one or more entities of said plurality of entities, or whether said droplet does not contain a said entity; sorting said droplet dependent on an outcome of said determination; and dispensing said sorted droplet into a reservoir, wherein said dispensing comprises: identifying said sorted droplet for dispensing; extracting said sorted droplet from a first fluidic flow path of said fluid by transferring said sorted droplet from said first fluidic flow path into a second fluidic flow path; and ejecting said sorted droplet from said second fluidic flow path into said reservoir by applying pressure to said second fluidic flow path.Type: ApplicationFiled: June 16, 2021Publication date: October 7, 2021Inventors: Frank F. CRAIG, Marian Rehak, David Holmes, Clive A. Smith, Xin Liu, Giuseppe Benazzi, Xin Li, Vinayaka Pawate, Robert Frank Marchington, Richard Francis Day, Michael Stewart Hazell
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Patent number: 11077441Abstract: Instruments and cartridges for processing droplets in emulsions containing biological entities such as cells. A method of such processing comprises providing a plurality of the entities in a fluid; preparing a droplet from the fluid; determining whether the droplet contains one or more entities of said plurality of entities, or whether said droplet does not contain a said entity; sorting said droplet dependent on an outcome of the determination; and dispensing the sorted droplet into a reservoir. The dispensing may comprise identifying and extracting the sorted droplet from a first fluidic flow path of said fluid by transferring the sorted droplet from into a second fluidic flow path and then ejecting the sorted droplet into a reservoir by applying pressure to the second fluidic flow path. The droplet contents may be tracked so that the contents of an individual droplet can be sorted, selectively dispensed, and retrieved.Type: GrantFiled: June 3, 2016Date of Patent: August 3, 2021Assignee: Sphere Fluidics LimitedInventors: Frank F. Craig, Marian Rehak, David Holmes, Clive A. Smith, Xin Liu, Giuseppe Benazzi, Xin Li, Vinayaka Pawate, Robert Frank Marchington, Richard Francis Day, Michael Stuart Hazell
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Publication number: 20180156792Abstract: A test device is disclosed for determining the presence or absence of a biological entity in a biological sample from a human or animal body, the test device comprising a sampling portion, the sampling portion comprising absorbent material forming a liquid flow path having a series of bends. The flow path provides a circuitous route for fluid such as buffer solution to flow within the sampling portion, improving combining of fluid with a sample received by the sampling portion.Type: ApplicationFiled: April 28, 2014Publication date: June 7, 2018Inventors: Sean Andrew PARSONS, Richard Francis DAY, Lucie BROWNING
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Patent number: 9682201Abstract: Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.Type: GrantFiled: June 17, 2015Date of Patent: June 20, 2017Assignee: Nektar TherapeuticsInventors: David Mark Blakey, Richard Francis Day
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Publication number: 20150283336Abstract: Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.Type: ApplicationFiled: June 17, 2015Publication date: October 8, 2015Applicant: NEKTAR THERAPEUTICSInventors: David Mark Blakey, Richard Francis Day
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Patent number: 9084862Abstract: Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.Type: GrantFiled: July 19, 2010Date of Patent: July 21, 2015Assignee: NEKTAR THERAPEUTICSInventors: David Mark Blakey, Richard Francis Day
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Patent number: 8499758Abstract: The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.Type: GrantFiled: April 30, 2008Date of Patent: August 6, 2013Assignee: Sun Pharma Advanced Research Company Ltd.Inventors: Subhas Balaram Bhowmick, Prashant Kane, Ganesh Sangaiah, Satish Madhukar Gokhale, Ajay Nandgaonkar, Abhijit Takale, Simon James Smith, Samantha Anne Musgrave, Richard Francis Day, Lee Wood, Becky Lynn Pilditch, David Stuart Harris, Jonathan Hugh Wilkins, Duncan Aleck Bishop, Matthew David Allen
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Publication number: 20130075939Abstract: A device (3) for frothing a liquid comprises a first space (10) having an outlet (11) for allowing content from the space (10) to flow out of the space (10), means (40) for supplying the liquid to be frothed to the first space (10), and a second space (50) for allowing the liquid to mix with a gas in order for a frothing process to take place. The second space (50) is open to the first space (10), and has an inlet (51) for receiving content from the first space (10), which is separated from the outlet (11) of the first space (10) by a free space (60) for containing the frothing gas. At the position of this free space (60), when the device (3) is operated and frothing gas is present, the frothing gas is allowed to flow into the second space (50).Type: ApplicationFiled: June 14, 2011Publication date: March 28, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Joeke Noordhuis, Richard Francis Day, Nathan James Wrench
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Publication number: 20120118284Abstract: Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.Type: ApplicationFiled: July 19, 2010Publication date: May 17, 2012Applicant: Nektar TherapeuticsInventors: David Mark Blakey, Richard Francis Day
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Publication number: 20100163042Abstract: The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.Type: ApplicationFiled: April 30, 2008Publication date: July 1, 2010Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Subhas Balaram Bhowmick, Prashant Kane, Ganesh Sangaiah, Satish Madhukar Gokhale, Ajay Nandgaonkar, Abhijit Takale, Simon James Smith, Samantha Anne Musgrave, Richard Francis Day, Lee Wood, Becky Lynn Pilditch, David Stuart Harris, Jonathan Hugh Wilkins, Duncan Aleck Bishop, Matthew David Allen