Abstract: A method includes performing a search of an inverted index structure indexing values of a column to generate an in-range indexed value set by identifying all indexed values of the inverted index structure falling within a range corresponding to a range-based filter. A set of characteristics of the in-range indexed value set are identified based on performing the search of an inverted index structure. When the set of characteristics compare favorably to the set of index-usage requirements, output is generated based on performing a plurality of searches to the inverted index structure based on the in-range indexed value set. When the set of characteristics compare unfavorably to the set of index-usage requirements, the output is generated without performing any searches to the inverted index structure.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: An assembly includes an implant and a control lead. The implant includes a tubular implant body, a circumferentially adjustable sealing collar coupled to the implant body, a rotatable sealer gear coupled to the sealing collar and configured to adjust the circumference of the sealing collar, and a locking member having a locked state and an unlocked state. The control lead is configured for rotating the locking member and moving the locking member from the locked state to the unlocked state. In the locked state, rotating the control lead does not adjust the circumference of the sealing member. In the unlocked state, rotating the control lead in a first direction rotates the locking member and the sealer gear and circumferentially expands the sealing collar. In the unlocked state, rotating the control lead in a second direction rotates the locking member and the sealer gear and circumferentially contracts the sealing collar.

Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient that includes a patient interface device with a tubing assembly structured to be disposed on the head of the patient, a mask having a sealing element structured to sealingly engage about the airway of the patient, and an adaptor. The adapter includes a flange portion that extends generally radially outward from a central aperture and a hollow male connector extending from the flange portion and coupled with a correspondingly-shaped female connector of the tubing assembly or the mask. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway structured to conduct the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: An example system includes a vehicle having a prime mover motively coupled to a drive line; a motor/generator selectively coupled to the drive line, and configured to selectively modulate power transfer between an electrical load and the drive line; a battery pack; a DC/DC converter electrically interposed between the motor/generator and the electrical load, and between the battery pack and the electrical load, the DC/DC converter comprising a DC/DC converter housing; and a covering tray positioned over a plurality of batteries of the battery pack, the covering tray comprising a connectivity layer configured to provide electrical connectivity to terminals of the plurality of batteries.

Abstract: A lottery ticket dispensing method provides different types of lottery tickets in a jurisdiction and includes providing first lottery tickets for sale from a dispenser for a first type of lottery game. Upon a player making a selection of one of the first lottery tickets for purchase, a controller in communication with the dispenser determines whether one or more other lottery games are available for play within the jurisdiction. The method assigns one or more companion games from the available other lottery games based on the player's selection of the first lottery ticket and predefined filter values. The companion games are presented to the player as a suggestion or recommendation for an additional lottery ticket purchase. Upon the player selecting one of the companion games for purchase, the additional lottery ticket is provided to the player from the dispenser.

Abstract: A method of assigning an identifier to a controller of a modular vacuum pumping and/or abatement system, the method including: determining, by a first controller of the modular vacuum pumping and/or abatement system, that a first identifier is to be assigned to a second controller of the modular vacuum pumping and/or abatement system, wherein the second controller is located at a module of the modular vacuum pumping and/or abatement system; transmitting, by the first controller, a first signal indicative of the first identifier to the second controller; receiving, by a user input device coupled to the module, a user input; and adopting, by the second controller, the first identifier as its identifier in response to the user input.

Abstract: In some examples, a method of making a filter includes heating a metal substrate to precipitate a first phase on a surface of the metal substrate from a metal alloy, the metal substrate defining a plurality of apertures configured to allow a gas to pass through the apertures. The metal substrate is the metal alloy including a first metal and a second metal. The method further includes growing a plurality of carbon nanotubes (CNTs) on the surface of the first metal of the first phase, and the CNTs are configured to capture at least one particle.

Abstract: The present invention relates to the treatment of autoimmune and allergic diseases by oromucosal administration of a formulation consisting of an optimized combination of antigen, tolerizing agent and mucoadhesive carrier for each immune disease indication.

Abstract: An autonomous mobile device (AMD) moves in a physical space and uses a dock located at a first pose. Sometimes a user may move the dock. To determine whether the dock has moved, the AMD compares first pose data that was previously obtained while at the dock in the first pose to second pose data, such as after a restart or after leaving the dock. If a difference between the first pose and the second pose is greater than a threshold, the dock has moved. The pose data may be determined using a simultaneous localization and mapping (SLAM) algorithm to process images from cameras on the AMD. Transform data that relates coordinates of the second pose to coordinates of the first pose may be determined. If the dock is used as an origin for a map of the physical space, the transform data may be used to update the map.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.

Abstract: A method of implanting a prosthetic implant includes advancing a prosthetic implant into a patient's vasculature with a delivery apparatus, the delivery apparatus comprising a catheter and a control lead, the catheter including a lumen extending therethrough, the control lead extending through the lumen of the catheter, the prosthetic implant comprising an implant body, a seal extending radially outwardly from the implant body, and a locking bar coupled to the implant body and releasably coupled to the control lead, the locking bar radially offset relative to the central longitudinal axis of the implant body. The method further includes rotating the control lead of the delivery apparatus in a first direction relative to the catheter such that the locking bar rotates in the first direction relative to the implant body and the implant body expands radially from a first radially compressed state to a first radially expanded state.

Abstract: Processes for an autonomous grain facility are described herein. The process could include sampling and grading. For sampling, the system controls a robot to capture position data of a trailer and area data of grain, determines one or more sampling areas within the trailer, and controls the robot to obtain a sample from each of the sampling areas. For grading, the system measures data with both a near infrared sensor and a second sensor, analyzes all of the data to determine a dispositive action to be performed on the respective sample, and controls the system to perform the dispositive action.

Abstract: A method of implanting a prosthetic medical device at a target implantation site is provided. The method first comprises advancing a first prosthetic medical device through a subject's vasculature to a target implantation site. The first prosthetic medical device comprises a coil having an inflow end portion, an outflow end portion, and a central longitudinal axis extending from the inflow end portion to the outflow end portion. The method further comprises expanding the first prosthetic medical device from a compressed state to an expanded state to engage native vascular tissue at the target implantation site. The method subsequently comprises docking a second prosthetic medical device within the first prosthetic medical device.

Abstract: A prosthetic heart valve can comprise a stent frame radially movable between a contracted configuration and a maximum expanded configuration. The stent assembly can comprise a plurality of longitudinally extending jack strut assemblies, wherein each jack strut assembly comprises a proximal jack strut comprising a distal surface, a distal jack strut comprising a proximal surface, and a jack screw connecting the proximal jack strut and the distal jack strut. The proximal surface of each distal jack strut does not contact the distal surface of each respective proximal jack strut when the stent assembly is in the contracted configuration. The proximal surface of each distal jack strut contacts the distal surface of each respective proximal jack strut when the stent assembly is in the maximum expanded configuration.

Abstract: A system for growing vegetation that includes a plurality of zones, each zone having environmental conditions that vary from environmental conditions in other zones, at least one zone sensor measuring environmental conditions in each zone, a local database operative to store sensor measurements from the zone sensors, a remote database operative to receive and to store a subset of the sensor measurements stored in the local database, and a remote computing device operatively connected to the remote database. The remote computing device operative to receive information regarding movements of batches of vegetation through the plurality of zones and, using the received information, associate sensor measurements of the environmental conditions the batch of vegetation is subjected to as it move through the zones. A timeline for a batch of vegetation can be created that indicates the environmental conditions the vegetation is subjected to moving through the zones.

Abstract: A vascular system includes a delivery apparatus and an endovascular device. The delivery apparatus including a catheter and a control lead. The control lead extends through a lumen of the catheter and is configured to be manipulated by a user. The endovascular device is releasably coupled to the delivery apparatus and includes an implant body, a seal extending radially outwardly from the implant body, and one or more tissue engaging elements. The seal is configured to contact native vascular tissue to reduce leakage between the native vascular tissue and the implant body. The tissue engaging elements are pivotable relative to the seal from a compressed state to an expanded state. In the compressed state, the tissue engaging elements are positioned so as to disengage the native vascular tissue. In the expanded state, the tissue engaging elements extend outwardly from the seal and are configured to engage the native vascular tissue.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: A prosthetic heart valve includes a frame, a valve, and an expansion element. The frame is movable between contracted and expanded configurations and includes first struts and second struts non-hingedly coupled together. The second struts are configured to pivot relative to the first struts as the frame moves between the contracted and expanded configurations. The valve is coupled to the frame and includes leaflets. The expansion element extends through a lumen of the first struts. The expansion element is slidable relative to the lumen of the first struts and is configured to move the frame incrementally from the contracted configuration and the expanded configuration and from the expanded configuration to the contracted configuration.

Abstract: This invention relates generally to monoclonal antibodies or antigen binding fragments thereof that specifically bind Toll-like Receptor 4 (TLR-4), to methods of using the anti-TLR4 antibodies to treat or prevent symptoms of Acute Respiratory Distress Syndrome (ARDS). This invention also relates to monoclonal antibodies or antigen binding fragments thereof that specifically bind to IP-10 and methods of using anti-IL-10 antibodies to treat or prevent symptoms of ARDS. The invention further provides routes of administrations and formulations for said methods.