Patents by Inventor Richard H. Baltz

Richard H. Baltz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ultra-High Throughput Screening of Natural Products
    Publication number: 20100311107
    Abstract: The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment.
    Type: Application
    Filed: July 27, 2010
    Publication date: December 9, 2010
    Inventors: Richard H. Baltz, Catherine Monahan, Christopher Murphy, Julia Penn, Daniel Ritz, Stephen Wrigley
  • Methods and Compositions for Ultra-High Throughput Screening of Natural Products
    Publication number: 20080318267
    Abstract: The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment.
    Type: Application
    Filed: December 16, 2005
    Publication date: December 25, 2008
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Richard H. Baltz, Catherine Monahan, Christopher Murphy, Julia Penn, Daniel Ritz, Stephen Wrigley
  • Glycopeptides produced using glycosyltransferase gtfE
    Patent number: 7439322
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: October 21, 2008
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • DNA encoding SPNF of the spinosyn cluster
    Patent number: 7015001
    Abstract: Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: March 21, 2006
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Biosynthetic genes for spinosyn insecticide production
    Publication number: 20040023343
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Application
    Filed: December 23, 2002
    Publication date: February 5, 2004
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Glycosyltransferase gene gtfE from Amycolatopsis orientalis
    Publication number: 20040018964
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Application
    Filed: March 27, 2003
    Publication date: January 29, 2004
    Applicant: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Glycosyltransferase gene gtfE from Amycolatopsis oreintalis
    Patent number: 6566100
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: May 20, 2003
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • SpnG, a gene for spinosyn insecticide biosynthesis
    Patent number: 6521406
    Abstract: Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: February 18, 2003
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Glycosyltransferase gene gtfE from amycolatopsis oreintalis
    Publication number: 20020155567
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Application
    Filed: February 20, 2001
    Publication date: October 24, 2002
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Biosynthetic genes for spinosyn insecticide production
    Patent number: 6274350
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: August 14, 2001
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, Kathryn P. Crawford, M. Christine Broughton, Krishnamurthy Madduri, Donald J. Merlo, Jan R. Turner, Patti J. Treadway, Clive Waldron
  • Glucosyltransferase gene gtfe from Amycolatopsis orientalis
    Patent number: 6232102
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: May 15, 2001
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Biosynthetic genes for spinosyn insecticide production
    Patent number: 6143526
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: November 7, 2000
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Glycosyltransferase gene gtfA from Amycolatopsis orientalis
    Patent number: 6087143
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene gtfC from Amycolatopsis orientalis
    Patent number: 6027928
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfC of Amycolatopsis orientalis. Also provided are vectors carrying the gtfC gene, transformed heterologous host cells for expressing the GtfC protein, and methods for producing glycopeptide compounds using the cloned gtfC gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 22, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene GFTD from amycolatopsis orientalis
    Patent number: 6025174
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and methods for producing glycopeptide compounds using the cloned gtfD gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene gtfB from Amycolatopsis orientalis
    Patent number: 6025173
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: February 15, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glucosltransferase gene GTFE from amycolatopsis orientalis
    Patent number: 5932464
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode the enzyme, transformed heterologous host cells for expressing the enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode the enzyme.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: August 3, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Glucosyltransferase gene GTFE from amycolatopsis orientalis
    Patent number: 5871983
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 16, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Glycosyltransferase gene gtfb from Amycolatopsis orientalis
    Patent number: 5821100
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene GtfA from Amycolatopsis orientalis
    Patent number: 5821099
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg