Patents by Inventor Richard H. Ferber

Richard H. Ferber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8900194
    Abstract: Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: December 2, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Graham M. Clarke, Michael D. Delmore, Michael K. Domroese, Richard H. Ferber, Jay D. Jacobs, Jamieson C. Keister, Franklyn L. Frederickson
  • Publication number: 20080063714
    Abstract: The invention comprises compositions and methods useful for encapsulation and controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non-covalently crosslinked by multi-valent cations, wherein the molecules that are non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character The compositions are characterized in that a guest molecule may be encapsulated within the matrix and subsequently released.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 13, 2008
    Inventors: Hassan Sahouani, Robert A. Scherrer, Kim M. Vogel, Dennis E. Vogel, Stephen W. Stein, Brian J. Gabrio, Stephanie F. Bernatchez, Richard H. Ferber, Wei Zou
  • Patent number: 6908453
    Abstract: Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: June 21, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Patrick R. Fleming, Michael D. Delmore, Luther E. Erickson, Richard H. Ferber
  • Patent number: 6881203
    Abstract: Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: April 19, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Michael D. Delmore, Patrick R. Fleming, Douglas A. Huntley, Jamieson C. Keister, Cristina U. Thomas, Richard H. Ferber
  • Publication number: 20030135161
    Abstract: Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.
    Type: Application
    Filed: January 15, 2002
    Publication date: July 17, 2003
    Inventors: Patrick R. Fleming, Michael D. Delmore, Luther E. Erickson, Richard H. Ferber
  • Patent number: 6576263
    Abstract: A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: June 10, 2003
    Assignee: 3M Innovative Properties Company
    Inventors: Myhanh T. Truong, Kaveh Pournoor, Hye-ok Choi, David J. Velasquez, Richard H. Ferber, Stephanie F. Bernatchez
  • Publication number: 20030045837
    Abstract: Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.
    Type: Application
    Filed: September 5, 2001
    Publication date: March 6, 2003
    Inventors: Michael D. Delmore, Patrick R. Fleming, Douglas A. Huntley, Jamieson C. Keister, Cristina U. Thomas, Richard H. Ferber
  • Publication number: 20020009492
    Abstract: A preformed object for delivering an active agent to a subject, the preformed object including crosslinked protein, and methods of making and using.
    Type: Application
    Filed: February 16, 2001
    Publication date: January 24, 2002
    Applicant: 3M Innovative Properties Company
    Inventors: Myhanh T. Truong, Kaveh Pournoor, Hye-Ok Choi, David J. Velasquez, Richard H. Ferber, Stephanie F. Bernatchez
  • Patent number: 5149719
    Abstract: A composition, and method of preparing such a composition, useful for the enhancement of the transdermal delivery of a medicament. The composition includes a medicament suspended in an aqueous solution of lower alcohol, to which solution is added an amount of higher alcohol sufficient to substantially saturate the composition.
    Type: Grant
    Filed: April 27, 1990
    Date of Patent: September 22, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Richard H. Ferber, Scott A. Burton
  • Patent number: 4385046
    Abstract: A novel class of chelated radio-labeled polysaccharide derivatives are useful for diagnosing formed, and forming, blood clots in a vascular system. Novel intermediate metal-binding compounds comprise a water-soluble polysaccharide moiety having an average of at least 0.25 anionic groups per monosaccharide unit, and at least one chelating group derived from amino acids, substituted cyclic acid anhydrides, or carbon disulfide. The intermediate compound is then reacted with a radioactive tracer metal compound.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: May 24, 1983
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Dean S. Milbrath, Richard H. Ferber, William E. Barnett