Patents by Inventor Richard H. Kline
Richard H. Kline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5792775Abstract: The present invention provides a family of tropane analogs. More particularly, the present invention provides a family of 4' and 4',4"-substituted-3.alpha.-(diphenylmethoxy)tropane analogs having the formula ##STR1## in which R is a functional group including, but not limited to, hydrogen, alkyl, alkoxy, arylalkyl, aryloxyalkyl, cinnamyl and acyl; and R.sup.1 and R.sup.2 are independently selected and are functional groups including, but not limited to, hydrogen, alkyl, alkoxy, hydroxy, halogen, cyano, amino and nitro. The benztropine analogs of the present invention have a high affinity for the dopamine transporter and inhibit dopamine uptake, but they do not exhibit a cocaine-like behavioral profile. Moreover, the present invention provides methods of using such benztropine analogs to treat cocaine abuse, to image dopamine transporter/cocaine binding sites, and to diagnose and/or monitor neurodegenerative disorders (e.g., Parkinson's disease).Type: GrantFiled: June 20, 1996Date of Patent: August 11, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Amy Hauck Newman, Andrew C. Allen, Richard H. Kline, Sari Izenwasser, Jonathan L. Katz
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Patent number: 4534091Abstract: An expanded metal battery grid and process for making same which grid has a supporting border comprising a thermoplastic ribbon folded lengthwise around the grid's edge and ultrasonically bonded to itself through interstices in the grid.Type: GrantFiled: August 8, 1983Date of Patent: August 13, 1985Assignee: General Motors CorporationInventor: Richard H. Kline
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Patent number: 4535040Abstract: An expanded metal battery grid and process for making same which grid has a supporting border comprising a thermoplastic ribbon folded lengthwise around the grid's edge and ultrasonically bonded to itself through interstices in the grid.Type: GrantFiled: December 27, 1983Date of Patent: August 13, 1985Assignee: General Motors CorporationInventor: Richard H. Kline
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Patent number: 4384031Abstract: A battery container, the walls of which, include integrally molded, resilient ribs extending at acute angles from the walls to retain the battery's electrochemical innards firmly in the container. Each as-molded rib is plastically deformed and reshaped so that a lead-in portion thereof near the container opening is at a lesser angle with respect to the wall than the undeformed portion of the rib which serves to resiliently retain the innards. The section of rib between the lead-in portion and retaining portion extends at various angles intermediate the other angles and provide an incline or ramp for facilitating insertion of the battery's innards into the container. The tooling used to plastically deform the lead-in portion of the rib may also include means for tearing the bottom of the rib away from the bottom of the container.Type: GrantFiled: October 13, 1981Date of Patent: May 17, 1983Assignee: General Motors CorporationInventor: Richard H. Kline
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Patent number: 4370434Abstract: Compounds of the formula: ##STR1## wherein R, R' and R.sup.2 are alkyl radicals having 1 to 20 carbon atoms, phenyl radicals which may be substituted by 1 or 2 alkyl groups having 1 to 8 carbon atoms, aralkyl radicals having 7 to 12 carbon atoms, or cycloalkyl radicals having 5 to 12 carbon atoms; and wherein R.sup.3 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms. These compounds have utility as synergistic stabilizers with phenolic type antioxidants for the stabilization of organic materials such as natural and synthetic polymers, rubbers, lubricants and oils, etc.Type: GrantFiled: April 5, 1982Date of Patent: January 25, 1983Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4362887Abstract: Compounds of the formula: ##STR1## wherein R, R' and R.sup.2 are alkyl radicals having 1 to 20 carbon atoms, phenyl radicals which may be substituted by 1 or 2 alkyl groups having 1 to 8 carbon atoms, aralkyl radicals having 7 to 12 carbon atoms, or cycloalkyl radicals having 5 to 12 carbon atoms; and wherein R.sup.3 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms. These compounds have utility as synergistic stabilizers with phenolic type antioxidants for the stabilization of organic materials such as natural and synthetic polymers, rubbers, lubricants and oils, etc.Type: GrantFiled: April 10, 1981Date of Patent: December 7, 1982Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4309818Abstract: A battery container, the walls of which, include integrally molded, resilient ribs extending at acute angles from the walls to retain the battery's electrochemical innards firmly in the container. Each as-molded rib is plastically deformed and reshaped so that a lead-in portion thereof near the container opening is at a lesser angle with respect to the wall than the undeformed portion of the rib which serves to resiliently retain the innards. The section of rib between the lead-in portion and retaining portion extends at various angles intermediate the other angles and provide an incline or ramp for facilitating insertion of the battery's innards into the container. The tooling used to plastically deform the lead-in portion of the rib may also include means for tearing the bottom of the rib away from the bottom of the container.Type: GrantFiled: May 27, 1980Date of Patent: January 12, 1982Assignee: General Motors CorporationInventor: Richard H. Kline
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Patent number: 4284823Abstract: There is disclosed a process comprising reacting a compound having the general structural Formula II: ##STR1## with a compound having the general Formula III: ##STR2## in the presence of a basic catalyst while dissolved in an organic solvent to yield an aldehyde having the structural Formula I: ##STR3## wherein R.sub.1 and R.sub.2 are the same or different radicals selected from the group consisting of tertiary alkyl radicals having from 4 to 12 carbon atoms, R.sub.3 and R.sub.4 are the same or different radicals selected from the group consisting of alkyl radicals containing from 1 to 12 carbon atoms, cycloalkyl radicals containing from 5 to 12 carbon atoms, phenyl and substituted phenyl radicals or R.sub.3 and R.sub.4 with the carbon atom to which they are joined may form a cycloalkyl ring of from 5 to 12 carbon atoms, R.sub.5 is selected from the group consisting of hydrogen, alkyl radicals containing from 1 to 12 carbon atoms, or a cycloalkyl radical containing 5 or 6 carbon atoms.Type: GrantFiled: October 15, 1979Date of Patent: August 18, 1981Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4260832Abstract: There is a process disclosed for alkylating the nucleus of a phenol, said process comprising reacting an .alpha., .omega.alkanediol containing from 3 to 8 carbon atoms with a phenol having an unsubstituted nuclear position para to the phenolic hydroxyl group; said phenol being selected from the group of alkylated phenols having tertiary alkyl groups of 4 to 8 carbon atoms in both positions ortho to the phenolic hydroxyl group, in the presence of an alkali metal hydroxide or alkoxide or alkali metal at a temperature from 200.degree. to 300.degree. C. while continuously removing the water by-product as it forms and obtaining as a product said phenol having a primary hydroxy terminated alkyl group of 3 to 8 carbon atoms in said para position.Type: GrantFiled: October 29, 1979Date of Patent: April 7, 1981Assignee: The Goodyear Tire & Rubber CompanyInventors: Dane K. Parker, Richard H. Kline
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Patent number: 4254020Abstract: Compounds of the formula: ##STR1## wherein R is selected from (1) alkyl radicals having 6 to 20 carbon atoms; (2) phenyl radicals which may be substituted by 1 or 2 alkyl groups having 1 to 8 carbon atoms; or (3) aralkyl radicals having 7 to 12 carbon atoms; and wherein R.sup.1 is selected from (1) alkylene radicals having 2 to 6 carbon atoms; (2) cycloalkylene radicals having 5 to 12 carbon atoms; (3) alkylcycloalkylene radicals of the formula --R.sub.3 --R.sub.2 (R.sub.4).sub.n, wherein R.sub.2 is a cycloalkylene radical having 5 to 12 carbon and R.sub.3 and R.sub.4 are alkylene radicals having 1 to 6 carbon atoms, and n equals 1 or 0; (4) or a group of the formula --R.sub.5 --YR.sub.6, wherein R.sub.5 and R.sub.6 are alkylene radicals having 2 to 6 carbon atoms and Y is oxygen, sulfur, or a 1,4-phenylene radical.Type: GrantFiled: November 16, 1979Date of Patent: March 3, 1981Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4216116Abstract: A combination of a phenolic antioxidant, such as the butylated reaction product of p-cresol and dicyclopentadiene and an ester such as 3,6,9-trioxaundecamethylene bis [3-(dodecylthio)propionate] is used to stabilize polymers against oxidative degradation.Type: GrantFiled: October 20, 1977Date of Patent: August 5, 1980Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4173574Abstract: Phenolic age resistors such as 4-(3,5-ditertiary butyl-4-hydroxyphenyl)-2-butyl 2-methyl-4-thia-6-octanoyloxyhexanoate are used as antioxidants in diene rubbers, such as butadiene-styrene types and in polyolefins, such as polypropylene.Type: GrantFiled: October 11, 1977Date of Patent: November 6, 1979Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4165333Abstract: Antioxidants such as S-[3-(3,5-ditert.-butyl-4-hydroxyphenyl) propyl] thiomethacrylate are used to stabilize polymers either by being physically incorporated therein or by being polymerized in combination with other monomer to form polymers with built-in antioxidant protection.Type: GrantFiled: February 21, 1978Date of Patent: August 21, 1979Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4152319Abstract: Amide and imide age resistors such as N-(3,5-di tert.butyl-4-hydroxyphenyl) acrylamide and N-(3,5-di tert.butyl-4-hydroxyphenyl) itaconimide, age resistant polymers having amide and imide age resistors physically combined therewith and age resistant polymeric compositions prepared by free radical polymerization techniques involving the use of said amides and imides as monomers.Type: GrantFiled: November 1, 1974Date of Patent: May 1, 1979Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4147880Abstract: Ester age resisters such as 4-anilinophenyl acrylate and 4-anilinophenyl methacrylate, age resistant polymers having ester age resisters physically combined therewith and age resistant polymeric compositions prepared by free radical polymerization techniques involving the use of said esters as monomers.Type: GrantFiled: September 22, 1975Date of Patent: April 3, 1979Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4117240Abstract: Antioxidants such as 2-(3,5-di tert.butyl-4-hydroxybenzyloxy) ethyl acrylate and 2-(3,5-di tert.butyl-4-hydroxybenzyloxy) ethyl methacrylate, age resistant polymers having age resistors physically combined therewith and age resistant polymeric compositions prepared by emulsion free radical polymerization techniques involving the use of said age resistors as monomers.Type: GrantFiled: November 13, 1975Date of Patent: September 26, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4108830Abstract: Phenolic antioxidants such as bis(3,5-di tert.butyl-4-hydroxyphenyl) 2,9-dimethyl-4,7-dithiadecanedioate are used to stabilize diene rubbers such as butadiene-styrene copolymers (SBR) and polyolefins such as polypropylene.Type: GrantFiled: March 31, 1976Date of Patent: August 22, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4097464Abstract: 2,6-Di tert alkyl-4-vinylphenols are copolymerized in free radical emulsion polymerization systems to form self-stabilizing polymers. Such polymers have the advantage that the antioxidant cannot be extracted or volatilized from the polymer.Type: GrantFiled: November 3, 1975Date of Patent: June 27, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4097527Abstract: Phenolic antioxidants such as 1,1-dimethyl-2-(3,5-di tert.butyl-4-hydroxyphenyl) ethyl amine and a method of preparing said antioxidants involving the reaction between a 3,5-di tert.alkyl-4-hydroxybenzyl halide; N,N-dialkyl amine or dithiocarbamate such as 3,5-di tert.butyl-4-hydroxybenzyl chloride; 2,6-di tert.butyl-4-dimethylaminomethylphenol or 3,5-di tert.butyl-4-hydroxybenzyl N,N-dimethyldithiocarbamate and a nitroalkane such as 2-nitropropane to produce a nitro compound such as 1,1-dimethyl-2-(3,5-di tert.butyl-4-hydroxyphenyl)-1-nitroethane which can be catalytically reduced to form the aminoalkyl phenol.Type: GrantFiled: December 9, 1971Date of Patent: June 27, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline
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Patent number: 4093591Abstract: Phenolic age resistors such as 4-(3,5-ditertiary butyl-4-hydroxyphenyl)-2-butyl 2-methyl-4-thia-6-octanoyloxy-hexanoate are used as antioxidants in diene rubbers, such as butadiene-styrene types and in polyolefins, such as polypropylene.Type: GrantFiled: November 8, 1976Date of Patent: June 6, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Richard H. Kline