Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: An automated peritoneal dialysis (APD) device, system and method is provided, which utilizes mechanisms to admix customized dialysate solutions from multiple sources, while maximizing volumetric accuracy. The present automated peritoneal dialysis (APD) device can accomplish these goals all within the convenience and comfort of the patient's home utilizing filtered tap water.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A system and corresponding method for electron cryomicroscopy, comprising: a field-emission gun for generating an electron beam, the field-emission gun being energized, in use, to generate a 80 keV to 120 keV electron beam which is emitted into a vacuum enclosure and towards a specimen holder; the vacuum enclosure containing, at least in part: an objective lens for focusing an image of the specimen, the objective lens being disposed in the path of the electron beam and having a chromatic aberration coefficient, Cc, selected to achieve a resolution value better than a desired amount; the specimen holder for holding a specimen, the specimen holder being disposed in the path of the electron beam; a cryostage for cooling a specimen; a cryo-shield for surrounding a specimen and reducing an ice contamination rate of the specimen; and a direct electron detector comprising an array of pixels, each pixel capable of detecting an incident electron that has passed through a sample and struck the pixel.

Abstract: Systems and methods for automatically adjusting an ultrasound display are provided according to one or more embodiments. The present disclosure provides a method for automatically adjusting a display, the method including: initializing an automated display control; receiving image data; determining a position or an orientation of a target relative to the display based on the image data; calculating an adjustment of the display based on the position or the orientation of the target relative to the display; and controlling at least one actuator based on the adjustment of the display to move the display.

Abstract: A method of performing a redirect in a browser viewing a page in a first-party domain is provided. The method includes the steps of checking for the presence of a cookie in the browser associated with a third-party domain, and in the absence of the third-party cookie, the method includes redirecting the browser from the first-party domain to the third-party domain and, in response, returning from the third-party domain, a fixed value cookie for storage in the browser.

Abstract: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: An ultrasound system is disclosed. The ultrasound system includes an ultrasound device. The ultrasound device includes a housing, a control panel coupled to the housing, and a receiver assembly coupled to the housing, wherein the receiver assembly includes a first contact surface. The ultrasound system further includes a transducer assembly having an ultrasound probe and a cartridge, wherein the cartridge includes a second contact surface. The cartridge is configured to be removably received in a slot of the receiver assembly such that the cartridge is movable between a removed position, in which the transducer assembly is not connected to the ultrasound device, and an engaged position, in which the cartridge is positioned in the slot and the first contact surface is electrically coupled to the second contact surface.

Abstract: A portable ultrasound system includes a main screen included in a hinged portion of the portable ultrasound system configured to open and close relative to a main housing of the portable ultrasound system, a touchscreen included on a top surface of the main housing of the portable ultrasound system, and a touchpad included on the top surface of the main housing of the portable ultrasound system. The system further includes a processing circuit configured to perform general computing operations, configured to receive ultrasound imaging data, and configured to provide ultrasound information to at least one of the main screen, the touchscreen, or the touchpad.

Abstract: A method of performing a redirect in a browser viewing a page in a first-party domain is provided. The method includes the steps of checking for the presence of a cookie in the browser associated with a third-party domain, and in the absence of the third-party cookie, the method includes redirecting the browser from the first-party domain to the third-party domain and, in response, returning from the third-party domain, a fixed value cookie for storage in the browser.