Patents by Inventor Richard Hochberg

Richard Hochberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11 beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
    Patent number: 9315539
    Abstract: The present invention relates to novel 11-? estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: April 19, 2016
    Assignee: YALE UNIVERSITY
    Inventor: Richard Hochberg
  • LOCALLY ACTIVE "SOFT" ANTIANDROGENS
    Publication number: 20140011785
    Abstract: The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 9, 2014
    Applicant: Yale University
    Inventor: Richard Hochberg
  • Locally active “soft” antiandrogens
    Patent number: 8552061
    Abstract: The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient. These compounds have the general chemical structure (I, II, III or IV).
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: October 8, 2013
    Assignee: Yale University
    Inventor: Richard Hochberg
  • LOCALLY ACTIVE "SOFT" ANTIANDROGENS
    Publication number: 20100184735
    Abstract: The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient.
    Type: Application
    Filed: May 2, 2008
    Publication date: July 22, 2010
    Inventor: Richard Hochberg
  • 15?-substituted estradiol carboxylic acid esters as locally active estrogens
    Patent number: 7015211
    Abstract: The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 15?-estradiol ester compounds is presented which exhibit excellent biological activity for use in pharmaceutical compositions for the treatment of symptomology associated with menopause. The present invention is therefore directed to compounds according to the structure: where X is R is H, a C1 to C5 alkyl group, optionally substituted with at least one halogen group, such as CH2CH2F, or other group (e.g., CH2CHF2, CH2CF3 or CF3 group); and m is from 0–5, preferably from 0–2.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: March 21, 2006
    Assignee: Yale University
    Inventor: Richard Hochberg
  • 15Alpha-substituted estradiol carboxylic acid esters as locally active estrogens
    Publication number: 20040198711
    Abstract: The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 15&agr;-estradiol ester compounds is presented which exhibit excellent biological activity for use in pharmaceutical compositions for the treatment of symptomology associated with menopause.
    Type: Application
    Filed: March 9, 2004
    Publication date: October 7, 2004
    Applicant: YALE UNIVERSITY
    Inventor: Richard Hochberg
  • 11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
    Publication number: 20040142915
    Abstract: The present invention relates to novel 11-&bgr; estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
    Type: Application
    Filed: October 1, 2003
    Publication date: July 22, 2004
    Applicant: YALE UNIVERSITY
    Inventor: Richard Hochberg
  • Progesterone receptor ligands
    Patent number: 4780420
    Abstract: Radiodinated and non-radiodinated 16.alpha.-iodo- and 17.alpha.-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: October 25, 1988
    Assignee: Yale University
    Inventors: Richard Hochberg, William Rosner, Robert Hoyte