Abstract: Antigen binding molecules capable of binding to CDI22 and/or common y? chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Abstract: Antigen binding molecules capable of binding to CD122 and/or common ? chain (CD132) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Abstract: The invention relates to pharmaceutical compositions comprising ?9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabigerol (CBG) and a terpene component, and their use in the treatment of chronic pain. The invention also relates to methods for treating chronic pain, especially chronic pain in athletes.

Abstract: An abrasive disc mounting assembly for attaching an abrasive disc to a rotary motor drive. The assembly includes a backing pad with a front face and a rear surface. A tapered recess is formed in the front face and extends into the backing pad, the recess having a flat base at its inward end. A hole is formed in the recess and extends through the backing pad from the base to the rear surface. The hole is centered within the recess. A grinder spindle is sized to fit within the hole. The spindle has threads formed on one end. The assembly also includes a nut with a shape that is complementary to the shape of the recess so that the nut seats within the recess. The recess and nut include anti-rotational features that prevent one from rotating relative to the other as the nut seats within the recess.

Abstract: Antigen binding molecules capable of binding to CD122 and/or common ? chain (CD132) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Abstract: The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and methods of using these compositions for treating osteochondral defects and full- or partial-thickness cartilage defects.

Abstract: A system dynamically controls position of a mobile offshore drilling unit relative to a subsea operation, an offshore location, or the like. The system has navigation units, acoustic units, and inertial units. The navigation units obtain position from one or more satellite navigation systems, and the acoustic units obtains position from one or more acoustic positioning reference systems. The inertial units obtains position of the unit from one or more inertial navigation systems, and this inertial position for each unit is based at least in part on the positions obtained from respective ones of the navigation and acoustic units. A control unit in operable communication with the inertial units determines dynamic positioning information from the inertial position of at least one of the inertial units. In turn, the control unit then operates equipment on the drilling unit to control its position dynamically.

Abstract: A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.

Abstract: A TGF-? decoy receptor comprising a TGF-? binding region and a lipid anchor region is disclosed. Also disclosed is a chimeric antigen receptor (CAR) comprising a TGF-? binding region. Also disclosed are compositions comprising, and methods using, the TGF-? decoy receptors and CARs.

Abstract: An abrasive disc mounting assembly for attaching an abrasive disc to a rotary motor drive. The assembly includes a backing pad with a front face and a rear surface. A tapered recess is formed in the front face and extends into the backing pad, the recess having a flat base at its inward end. A hole is formed in the recess and extends through the backing pad from the base to the rear surface. The hole is centered within the recess. A grinder spindle is sized to fit within the hole. The spindle has threads formed on one end. The assembly also includes a nut with a shape that is complementary to the shape of the recess so that the nut seats within the recess. The recess and nut include anti-rotational features that prevent one from rotating relative to the other as the nut seats within the recess.

Abstract: A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analyzing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.

Abstract: The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

Abstract: The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

Abstract: A system dynamically controls position of a mobile offshore drilling unit relative to a subsea operation, an offshore location, or the like. The system has navigation units, acoustic units, and inertial units. The navigation units obtain position from one or more satellite navigation systems, and the acoustic units obtains position from one or more acoustic positioning reference systems. The inertial units obtains position of the unit from one or more inertial navigation systems, and this inertial position for each unit is based at least in part on the positions obtained from respective ones of the navigation and acoustic units. A control unit in operable communication with the inertial units determines dynamic positioning information from the inertial position of at least one of the inertial units. In turn, the control unit then operates equipment on the drilling unit to control its position dynamically.

Abstract: The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

Abstract: A method of differentiating cells into CK19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the scaffold, the cells being capable of differentiation; incubating the scaffold having the cells in a cell growth media; and incubating the scaffold having the cells in an osteogenic differentiation medium sufficient for CK19-positive cells to be generated in the scaffold. The tissue scaffold can be a decellularized Whartons' jelly matrix. The cell growth media excludes osteogenic differentiation components: dexamethasone, ?-glycerophosphate, 1?,25-hydroxyvitamin D3, and ascorbic acid 2-phosphate. The osteogenic differentiation medium includes the osteogenic differentiation components. The cells can be mesenchymal cells, such as WJMSCs.

Abstract: A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.

Abstract: The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided.

Abstract: The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and methods of using these compositions for treating osteochondral defects and full- or partial-thickness cartilage defects.

Abstract: This disclosure provides a method of isolating peptides having cell-penetrating function, wherein the peptides are detected as biotinylated molecules only following their translocation through the cell membrane. The disclosure also provides methods for validating the cell-penetrating function of the peptides, or that may be employed in their own right to isolate such peptides, wherein the peptides are detectable by virtue of their ability to transport a detectable cargo into the cytoplasm, such as a cargo toxin or a fragment of a green fluorescent protein (GFP) that is required for complementation of a functional GFP. The disclosure also provides non-canonical peptides having cell-penetrating function that differ structurally from known CPPs such as TAT, VP22, transportan and penetratin, and that are capable of translocating cell membranes and escaping the endosome. The disclosed peptides have utility in transporting cargo therapeutics and diagnostics into cells.