Patents by Inventor Richard L. Stevens

Richard L. Stevens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5968782
    Abstract: Compositions containing a Trypson-like serine protease from mast cells ("tryptase-7") are provided. The compositions are useful for treating blood clot formation in vitro and in in vitro. Also provided is a novel bioengineering method to produce the tryptase-7 and other serine proteases in active form and in large quantities.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: October 19, 1999
    Assignee: Brigham and Womens's Hospital, Inc.
    Inventor: Richard L. Stevens
  • Patent number: 5955431
    Abstract: Compositions and methods for inhibiting a complex containing a mast cell protease are provided. The compositions are useful for treating inflammatory disorders, such as asthma, that are mediated by release of a tryptase-6 protein. Methods for identifying additional specific inhibitors of a complex containing tryptase-6 protein and a serglycin glycosaminoglycan also are provided.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: September 21, 1999
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Richard L. Stevens, Chifu Huang
  • Patent number: 5340739
    Abstract: A negative transcription regulatory element (a constitutive suppressor) between residues -250 and -190 of the 5' flanking region of the mouse serglycin gene, a positive (hematopoietic cell enhancer) regulatory element located between residues -118 and -81, an equivalent of the TATA- box and a novel eukaryotic promoter that utilizes such equivalent, vectors containing such elements and hosts transformed therewith, are described. These regulatory elements, vectors and hosts are useful in gene transcription of heterologous genes in eukaryotic cells, and especially in hematopoietic cells. In addition, transcriptional factors that bind to these elements are described.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: August 23, 1994
    Assignee: Brigham & Women's Hospital
    Inventors: Richard L. Stevens, Shalom Avraham
  • Patent number: 5317085
    Abstract: This invention relates to the identification, characterization, and sequencing of genetic sequences of human secretory granule proteoglycan peptide core protein, recombinant DNA clones directed against this sequence and against the sequence of the antisense RNA, and antibodies which recognize the native human secretory granule proteoglycan.
    Type: Grant
    Filed: July 7, 1992
    Date of Patent: May 31, 1994
    Assignee: Brigham And Women's Hospital
    Inventors: Richard L. Stevens, John H. Weis, Christopher F. Nicodemus
  • Patent number: 5171674
    Abstract: This invention relates to the identification, characterization, and sequencing of genetic sequences of human secretory granule proteoglycan peptide core protein, recombinant DNA clones directed against this sequence and against the sequence of the antisense RNA, and antobodies which recognize the native human secretory granule proteoglycan.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: December 15, 1992
    Assignee: Brigham and Women's Hospital
    Inventors: Richard L. Stevens, John H. Weis, Christopher F. Nicodemus
  • Patent number: 5022377
    Abstract: A portable bow press for facilitating repair and adjustment of an archer's compound-type bow is disclosed which includes a first elongated member having a threaded aperture formed centrally therein and removable structure at each end for engaging the ends of each of the bow limbs. A second elongated member is threaded through the threaded aperture to engage the handle of the bow and apply a force against the handle to remove tension from the bow string and tension cable to allow needed repairs to the various elements of the bow. A sleeve member is mounted on the second elongated member for travel therealong and includes a hook member to hold one end of a scale while the other end of the scale is attached to the center of the bow string.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: June 11, 1991
    Inventor: Richard L. Stevens
  • Patent number: 4411432
    Abstract: In a travel game for two or more players, a game board displays a geographical area with a plurality of locations linked by travel routes marked with travel distances. Each player has a position piece for moving from a designated origin along routes he chooses with the object being the first to arrive at a designated destination. A plurality of tokens each bearing a number are obtained by the players by chance. Each player combines his tokens to form combination numbers equal to the travel distances of his chosen routes and expends the tokens for the right to travel those routes. Each player has a board piece which he may place on the board on a route of his choice to indicate that passage along that route is obstructed.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: October 25, 1983
    Inventor: Richard L. Stevens