Patents by Inventor Richard Lawn

Richard Lawn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050214793
    Abstract: The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as to methods for producing ABC1 polypeptides. The invention also relates to antibodies that bind specifically to ABC1 polypeptides. In addition, the invention relates to methods for increasing cholesterol efflux as well as to methods for increasing ABC1 expression and activity. The present invention further relates to methods for identifying compounds that modulate the expression of ABC1 and methods for detecting the comparative level of ABC1 polypeptides and polynucleotides in a mammalian subject. The present invention also provides kits and compositions suitable for screening compounds to determine the ABC1 expression modulating activity of the compound, as well as kits and compositions suitable to determine whether a compound modulates ABC1-dependent cholesterol efflux.
    Type: Application
    Filed: October 25, 2004
    Publication date: September 29, 2005
    Applicants: CV Therapeutics, Inc., University of Washington
    Inventors: Richard Lawn, David Wade, Michael Garvin, John Oram
  • Patent number: 6919339
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: July 19, 2005
    Assignee: CV Theapeutics, Inc.
    Inventors: Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20050009089
    Abstract: The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as to methods for producing ABC1 polypeptides. The invention also relates to antibodies that bind specifically to ABC1 polypeptides. In addition, the invention relates to methods for increasing cholesterol efflux as well as to methods for increasing ABC1 expression and activity. The present invention further relates to methods for identifying compounds that modulate the expression of ABC1 and methods for detecting the comparative level of ABC1 polypeptides and polynucleotides in a mammalian subject. The present invention also provides kits and compositions suitable for screening compounds to determine the ABC1 expression modulating activity of the compound, as well as kits and compositions suitable to determine whether a compound modulates ABC1-dependent cholesterol efflux.
    Type: Application
    Filed: August 18, 2004
    Publication date: January 13, 2005
    Applicant: CV Therapeutics, Inc.
    Inventors: Richard Lawn, David Wade, Michael Garvin
  • Patent number: 6842654
    Abstract: An online algorithm exchange is presented herein. The online algorithm exchange provides access to a plurality of coloring algorithms from any number of developers. Users can select a particular algorithm for use as well as specify particular color measurements as inputs thereto. The color measurements can be selected from a database at the algorithm exchange, or provided by the user from a client terminal.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: January 11, 2005
    Assignee: eWarna.com International Holdings Limited
    Inventors: Richard Lawn, Man Hon Shiew
  • Patent number: 6713650
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: March 30, 2004
    Inventors: Prabha N. Ibrahim, Robert Jiang, Christopher Morrison, Kevin Shenk, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20030165924
    Abstract: The present invention relates to purified polynucleotides and compositions comprising pluralities of polynucleotides that are differentially expressed during foam cell development and are associated with atherosclerosis. The present invention presents the use of the compositions as elements on a substrate, and provides methods for using the compositions and polynucleotides.
    Type: Application
    Filed: October 4, 2002
    Publication date: September 4, 2003
    Inventors: Dov Shiffman, Roland Somogyi, Richard Lawn, Jeffrey J. Seilhamer, J. Gordon Porter, Thomas Mikita, Julie Tai
  • Patent number: 6548548
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: April 15, 2003
    Assignee: CV Therapeutics, Inc.
    Inventors: Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20020128266
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Application
    Filed: December 4, 2001
    Publication date: September 12, 2002
    Inventors: Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20020111364
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Application
    Filed: December 6, 2001
    Publication date: August 15, 2002
    Inventors: Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20020082257
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Application
    Filed: December 5, 2001
    Publication date: June 27, 2002
    Inventors: Prabha N. Ibrahim, Robert Jiang, Christopher Morrison, Kevin Shenk, Jeff A. Zablocki, Richard Lawn
  • Publication number: 20020042842
    Abstract: An online algorithm exchange is presented herein. The online algorithm exchange provides access to a plurality of coloring algorithms from any number of developers. Users can select a particular algorithm for use as well as specify particular color measurements as inputs thereto. The color measurements can be selected from a database at the algorithm exchange, or provided by the user from a client terminal.
    Type: Application
    Filed: October 4, 2001
    Publication date: April 11, 2002
    Inventors: Richard Lawn, Man Hon Shiew