Patents by Inventor Richard M. Weinshilboum

Richard M. Weinshilboum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3?-phosphoadenosine-5?-phosphosulfate synthetase 1 (PAPSS1) sequence variants
    Patent number: 7288399
    Abstract: Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: October 30, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase 2B1 pharmacogenetics
    Patent number: 7288642
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods for determining the sulfonator status of a subject also are described. In addition, methods for predicting the therapeutic efficacy of a compound in a subject are described, as are methods for estimating the dose of a compound to be administered to a subject.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: October 30, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum
  • Arsenic methyltransferase sequence variants
    Patent number: 7250290
    Abstract: Isolated ASMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as ASMT allozymes. Methods for determining if a mammal is at risk for toxicity from acute or chronic arsenic exposure also are described.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: July 31, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum, Thomas C. Wood
  • 3?-phosphoadenosine -5?-phosphosulfate synthetase 2 (PAPSS2) sequence variants
    Patent number: 7186551
    Abstract: Isolated PAPSS2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS2 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: March 6, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • 3?-phosphoadenosine-5?-phosphosulfate synthetase 1 (PAPSS1) sequence variants
    Patent number: 7067311
    Abstract: Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: June 27, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase SULT2A1 sequence variants
    Patent number: 7056731
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to a heart condition or cancer also are described.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: June 6, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase sequence variants
    Patent number: 7026163
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or cancer also are described.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: April 11, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert R. Freimuth, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase sequence variants
    Publication number: 20040235098
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining a risk estimate for hormone dependent disease and methods for determining sulfonator status also are described.
    Type: Application
    Filed: September 23, 2003
    Publication date: November 25, 2004
    Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporation
    Inventors: Richard M. Weinshilboum, Rebecca B. Raftogianis, Thomas C. Wood, Diane M. Otterness
  • Sulfotransferase sequence variants
    Publication number: 20020039775
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining a risk estimate for hormone dependent disease and methods for determining sulfonator status also are described.
    Type: Application
    Filed: April 10, 2001
    Publication date: April 4, 2002
    Applicant: Mayo Foundation for Medical Education and Research, Minnesota corporation
    Inventors: Richard M. Weinshilboum, Rebecca B. Raftogianis, Thomas C. Wood, Diane M. Otterness
  • Histamine-N-methyltransferase variants associated with histaminergic disease
    Patent number: 6316188
    Abstract: Methods for characterizing patients diagnosed with histaminergic diseases are described. Nucleic acid molecules that include a histamine-N-methyltransferase intron variant sequence associated with a histaminergic disease also are described.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: November 13, 2001
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Lan Yan, Stephen Liggett, Raymond E. Galinsky, Richard M. Weinshilboum, Herb M. Lachman
  • Sulfotransferase sequence variants
    Patent number: 6265561
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining a risk estimate for hormone dependent disease and methods for determining sulfonator status also are described.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: July 24, 2001
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard M. Weinshilboum, Rebecca B. Raftogianis, Thomas C. Wood, Diane M. Otterness
  • cDNA cloning and expression of human liver estrogen sulfotransferase
    Patent number: 5744355
    Abstract: The present invention provides an isolated and purified human DNA molecule that encodes human estrogen sulfotransferase.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: April 28, 1998
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard M. Weinshilboum, Ibrahim A. Aksoy, Thomas C. Wood
  • cDNA cloning and expression of human liver estrogen sulfotransferase
    Patent number: 5714594
    Abstract: The present invention provides an isolated and purified human DNA molecule consisting essentially of a DNA segment encoding an estrogen sulfotransferase protein or biologically active derivative thereof.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: February 3, 1998
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard M. Weinshilboum, Ibrahim A. Aksoy, Thomas C. Wood
  • Stably-transformed cells expressing human thiopurine methyltransferase
    Patent number: 5470737
    Abstract: A recombinant DNA sequence is provided which encodes human thiopurine methyl transferase (TPMT), as well as a mammalian cell line having said recombinant DNA sequence incorporated into the genome thereof, so that the cells express high levels of human TPMT activity.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: November 28, 1995
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard M. Weinshilboum, Ronald Honchel, Ibrahim A. Aksoy, Carol L. Szumlanski, Thomas C. Wood, Diane M. Otterness, Eric D. Wieben