Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Disclosed are methods for determining copy number variation (CNV) known or suspected to be associated with a variety of medical conditions. In some embodiments, methods are provided for determining copy number variation of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some embodiments, methods are provided for determining CNVs known or suspected to be associated with a variety of medical conditions. Some embodiments disclosed herein provide methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter. In some implementations, information from fragments of different sizes are used to evaluate copy number variations. In some implementations, one or more t-statistics obtained from coverage information of the sequence of interest is used to evaluate copy number variations. In some implementations, one or more fetal fraction estimates are combined with one or more t-statistics to determine copy number variations.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Disclosed are methods for determining copy number variation (CNV) known or suspected to be associated with a variety of medical conditions. In some embodiments, methods are provided for determining copy number variation of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some embodiments, methods are provided for determining CNVs known or suspected to be associated with a variety of medical conditions. Some embodiments disclosed herein provide methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter. In some implementations, information from fragments of different sizes are used to evaluate copy number variations. In some implementations, one or more t-statistics obtained from coverage information of the sequence of interest is used to evaluate copy number variations. In some implementations, one or more fetal fraction estimates are combined with one or more t-statistics to determine copy number variations.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

Abstract: Various systems, methods, and processes for interrupting and/or terminating an archive operation and/or archive process are disclosed. A determination is made as to whether an archive operation is ongoing. Files being written to a storage device as part of the archive operation are monitored. Upon receiving a request to interrupt or terminate the archive operation, the initiation of writing of new files to the storage device is inhibited, and the completion of the writing the files being written to the storage device is permitted. The archive operation and/or archive process is then interrupted or terminated without the risk of data corruption.

Abstract: The invention is a system for protecting the security of computer files. It has hardware elements, including a programmable auxiliary memory and control unit along with associated software elements. The security subsystem is installed on the host computer bus so that it resides in the control logic, address, and data signal path between the computer storage device and central processing unit. The security system is accessible by the computer operating system only during installation and initialization. Thereafter it is inaccessible to or by the operating system. Supervisor determined criteria for access permission to read, write and execute files are entered into the auxiliary memory system where they are protected from alteration. The security system will deny access to users with invalid entry criteria and refuse to write data to the file storage device when unauthorized operations have been attempted.

Abstract: The invention is a system for protecting the security of computer files. It has hardware elements, including a programmable auxiliary memory and control unit along with associated software elements. The security subsystem is installed on the host computer bus so that it resides in the control logic, address, and data signal path between the computer storage device and central processing unit. The security system is accessible by the computer operating system only during installation and initialization. Thereafter it is inaccessible to or by the operating system. Supervisor determined criteria for access permission to read, write and execute files are entered into the auxiliary memory system where they are protected from alteration. The security system will deny access to users with invalid entry criteria and refuse to write data to the file storage device when unauthorized operations have been attempted.

Abstract: A tube checking system is made up of a template placed on a flat metallic surface, and a series of adjustable holding fixtures places at selected positions along the template. The template has a computer aided layout of a plan view of a formed tube inscribed on a film with selected check points along the layout showing the height and angle of the tubing above the check point. Each holding fixture is adjustable as to height and angle, is indexed to align to the check point, and has a switchable on off magnet in the base to secure the fixture in position.